TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.341 | Formula: C18H15F2N5O
H donors: 1 H acceptors: 4 LogP: 1.95 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)[C@@](Cn1cnc2c1cccc2)(Cn1cncn1)O
InChi: 1S/C18H15F2N5O/c19-13-5-6-14(15(20)7-13)18(26,9-25-11-21-10-23-25)8-24-12-22-16-3-1-2-4-17(16)24/h1-7,10-12,26H,8-9H2/t18-/m1/s1
InChiKey: WHGGKHLCJNIFCM-GOSISDBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.051	0.1844	0.1844
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.051	0.1844	0.1844
Onchocerca volvulus		0.051	0.1844	0.4591
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.1844	0.1844
Onchocerca volvulus		0.051	0.1844	0.4591
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase csk	0.051	0.1844	0.1844
Echinococcus multilocularis	heat shock protein 70	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine kinase	0.051	0.1844	0.1844
Onchocerca volvulus		0.051	0.1844	0.4591
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Leishmania major	hypothetical protein, conserved	0.051	0.1844	0.1844
Echinococcus multilocularis	activin receptor type	0.051	0.1844	0.1844
Echinococcus granulosus	H:Cl exchange transporter 4	0.0149	0.037	0.037
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Entamoeba histolytica	serine/threonine kinase, putative	0.051	0.1844	0.8859
Echinococcus multilocularis	tyrosine protein kinase csk	0.051	0.1844	0.1844
Toxoplasma gondii	CBS domain-containing protein	0.0149	0.037	0.037
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Schistosoma mansoni	hypothetical protein	0.051	0.1844	0.1844
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Leishmania major	protein kinase, putative	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Giardia lamblia	Kinase, NEK	0.051	0.1844	1
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TK family protein kinase	0.051	0.1844	1
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trypanosoma brucei	Voltage-gated Chloride channel Like 1	0.0149	0.037	0.037
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Brugia malayi	C-terminal src kinase protein 1	0.051	0.1844	0.1844
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.051	0.1844	0.1844
Leishmania major	chloride channel protein, putative	0.0149	0.037	0.037
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	cysteine surface protein, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Brugia malayi	bone morphogenetic protein type 1 receptor	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.051	0.1844	0.1844
Toxoplasma gondii	chloride transporter, chloride channel (ClC) family protein	0.0149	0.037	0.037
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Toxoplasma gondii	protein kinase domain-containing protein	0.051	0.1844	0.1844
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Echinococcus multilocularis	epidermal growth factor receptor	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.051	0.1844	0.1844
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.2506	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.051	0.1844	1
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	activin receptor type	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Brugia malayi	hypothetical protein	0.051	0.1844	0.1844
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Abl	0.051	0.1844	0.1844
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	tyrosine protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	protein kinase, putative	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Chlamydia trachomatis	Mg++ transporter	0.0149	0.037	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	AGC family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Leishmania major	inosine-5-monophosphate dehydrogenase	0.2506	1	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.051	0.1844	0.8859
Echinococcus granulosus	protein kinase	0.051	0.1844	0.1844
Toxoplasma gondii	CBS family protein	0.0149	0.037	0.037
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.2506	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.051	0.1844	0.1844
Trypanosoma brucei	AMP-activated protein kinase, gamma regulatory subunit	0.0149	0.037	0.037
Echinococcus granulosus	kinase suppressor of Ras 1	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Onchocerca volvulus		0.051	0.1844	0.4591
Trypanosoma cruzi	GMP reductase	0.2506	1	1
Onchocerca volvulus		0.051	0.1844	0.4591
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Echinococcus multilocularis	protein KINase family member (kin 25)	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Schistosoma mansoni	protein tyrosine kinase	0.051	0.1844	0.1844
Brugia malayi	Immunoglobulin I-set domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	loechrig isoform VII	0.0149	0.037	0.037
Plasmodium vivax	tyrosine kinase-like protein, putative	0.051	0.1844	0.1964
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	SH2 domain containing protein	0.051	0.1844	0.1844
Schistosoma mansoni	ephrin receptor	0.051	0.1844	0.1844
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0149	0.037	0.2009
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	protein kinase domain-containing protein	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	insulin receptor	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase csk	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus granulosus	retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase csk	0.051	0.1844	0.1844
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.2357	0.9392	1
Leishmania major	chloride channel protein, putative	0.0149	0.037	0.037
Treponema pallidum	hemolysin (tlyC)	0.0149	0.037	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	hypothetical protein	0.051	0.1844	0.1844
Echinococcus granulosus	retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Brugia malayi	Immunoglobulin I-set domain containing protein	0.051	0.1844	0.1844
Echinococcus granulosus	protein tyrosine kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.051	0.1844	0.8859
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0149	0.037	0.037
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trypanosoma brucei	GMP reductase	0.2506	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	H(+):Cl() exchange transporter 4	0.0149	0.037	0.037
Entamoeba histolytica	tyrosin kinase, putative	0.051	0.1844	0.8859
Toxoplasma gondii	IMP dehydrogenas	0.2506	1	1
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.119	0.4625	0.4418
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus multilocularis	receptor type guanylyl cyclase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.1042	0.4017	0.4017
Trypanosoma cruzi	protein kinase, putative	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0149	0.037	0.037
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	chloride channel protein, putative	0.0149	0.037	0.037
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	TK/EPH protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0149	0.037	0.037
Entamoeba histolytica	serine/threonine kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Onchocerca volvulus		0.051	0.1844	0.4591
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.051	0.1844	0.1844
Brugia malayi	Guanylyl cyclase protein 23	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.051	0.1844	0.8859
Onchocerca volvulus		0.051	0.1844	0.4591
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.051	0.1844	0.1844
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0149	0.037	0.2009
Echinococcus granulosus	retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.2357	0.9392	0.9369
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Onchocerca volvulus		0.051	0.1844	0.4591
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Echinococcus granulosus	H:Cl exchange transporter 3	0.0149	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.0149	0.037	0.037
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	H:Cl exchange transporter 7	0.0149	0.037	0.037
Echinococcus granulosus	tyrosine protein kinase shark	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Trichomonas vaginalis	protein tyrosine kinase, putative	0.051	0.1844	1
Entamoeba histolytica	hypothetical protein	0.0568	0.2082	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.051	0.1844	0.1844
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Srms	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	protein kinase atn1, putative	0.051	0.1844	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.051	0.1844	0.1844
Onchocerca volvulus		0.051	0.1844	0.4591
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Echinococcus multilocularis	natriuretic peptide receptor 1	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Brugia malayi	chloride channel protein 7	0.0149	0.037	0.037
Echinococcus granulosus	epidermal growth factor receptor	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Plasmodium vivax	protein kinase, putative	0.051	0.1844	0.1964
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	SNF4:AMP activated protein kinase gamma subunit	0.0149	0.037	0.037
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.051	0.1844	0.1844
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Echinococcus multilocularis	H(+):Cl() exchange transporter 7	0.0149	0.037	0.037
Trypanosoma brucei	Voltage-gated Chloride channel Like 3	0.0149	0.037	0.037
Echinococcus granulosus	fibroblast growth factor receptor 4	0.051	0.1844	0.1844
Brugia malayi	ancient conserved domain protein 2	0.0149	0.037	0.037
Echinococcus granulosus	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Entamoeba histolytica	tyrosin kinase, putative	0.051	0.1844	0.8859
Schistosoma mansoni	ephrin receptor	0.051	0.1844	0.1844
Echinococcus granulosus	c src tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	serine/threonine kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.1042	0.4017	0.4017
Leishmania major	guanosine monophosphate reductase	0.2506	1	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.051	0.1844	0.1844
Onchocerca volvulus		0.0149	0.037	0.0922
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	ephrin type A receptor 4 A	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Echinococcus multilocularis	c src tyrosine kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.1316	0.5138	0.4951
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0149	0.037	0.037
Echinococcus multilocularis	insulin receptor	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0149	0.037	0.037
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Blk	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Echinococcus multilocularis	protein tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.051	0.1844	0.1844
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.051	0.1844	0.4591
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0149	0.037	0.2009
Echinococcus granulosus	activated cdc42 kinase 1	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/DDR protein kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Giardia lamblia	Kinase	0.051	0.1844	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase csk	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Onchocerca volvulus		0.051	0.1844	0.4591
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase ABL1	0.051	0.1844	0.1844
Brugia malayi	SRC-1	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein	0.0568	0.2082	1
Loa Loa (eye worm)	chloride channel 3	0.0149	0.037	0.037
Loa Loa (eye worm)	serine/threonine protein kinase	0.051	0.1844	0.1844
Plasmodium falciparum	protein MAM3, putative	0.0149	0.037	0.0394
Brugia malayi	CLC chloride channel protein	0.0149	0.037	0.037
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.2506	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.2357	0.9392	1
Echinococcus multilocularis	protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.2506	1	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.051	0.1844	0.1844
Entamoeba histolytica	receptor protein kinase, putative	0.051	0.1844	0.8859
Echinococcus multilocularis	transfer RNA-Thr	0.051	0.1844	0.1844
Plasmodium falciparum	protein kinase, putative	0.051	0.1844	0.1964
Loa Loa (eye worm)	loechrig isoform VII	0.0149	0.037	0.037
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Toxoplasma gondii	STE kinase	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase csk	0.051	0.1844	0.1844
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Brugia malayi	CBS domain containing protein	0.0149	0.037	0.037
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Brugia malayi	protein-tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.051	0.1844	0.4591
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.051	0.1844	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/Met protein kinase	0.051	0.1844	0.1844
Echinococcus granulosus	SNF4:AMP activated protein kinase gamma subunit	0.0149	0.037	0.037
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Brugia malayi	ancient conserved domain protein 4	0.0149	0.037	0.037
Entamoeba histolytica	protein kinase, putative	0.0568	0.2082	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	tyrosine kinase	0.051	0.1844	0.1844
Trypanosoma brucei	Pseudokinase, putative	0.051	0.1844	0.1844
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0149	0.037	0.037
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine kinase	0.051	0.1844	0.1844
Giardia lamblia	Protein 21.1	0.051	0.1844	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	ephrin receptor 1 precursor	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0149	0.037	0.037
Loa Loa (eye worm)	RGC/RGC protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Schistosoma mansoni	chloride channel protein	0.0149	0.037	0.037
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	SRC-1	0.051	0.1844	0.1844
Trichomonas vaginalis	STE family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	GMP reductase	0.1042	0.4017	0.4017
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Echinococcus granulosus	raf serine:threonine protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Entamoeba histolytica	hypothetical protein	0.0568	0.2082	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0568	0.2082	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Onchocerca volvulus		0.051	0.1844	0.4591
Onchocerca volvulus		0.051	0.1844	0.4591
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Schistosoma mansoni	chloride channel protein	0.0149	0.037	0.037
Schistosoma mansoni	serine/threonine protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.2506	1	1
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Schistosoma mansoni	serine/threonine RGC	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.051	0.1844	0.1844
Plasmodium falciparum	protein kinase, putative	0.051	0.1844	0.1964
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	RGC/RGC protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	receptor protein kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.051	0.1844	0.1844
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.051	0.1844	1
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	kinase suppressor of Ras 1	0.051	0.1844	0.1844
Echinococcus granulosus	AMP activated protein kinase gamma regulatory	0.0149	0.037	0.037
Echinococcus multilocularis	tyrosine protein kinase HCK	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Entamoeba histolytica	ankyrin repeat protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.051	0.1844	0.1844
Onchocerca volvulus	Tyrosine kinase homolog	0.051	0.1844	0.4591
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.051	0.1844	1
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.2506	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.051	0.1844	0.1964
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	RGC/RGC protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/ROR protein kinase	0.051	0.1844	0.1844
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.1316	0.5138	0.4951
Loa Loa (eye worm)	TK/ACK protein kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.051	0.1844	0.1844
Leishmania major	CBS domain protein, conserved	0.0149	0.037	0.037
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Onchocerca volvulus		0.051	0.1844	0.4591
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0149	0.037	0.037
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Brugia malayi	GMP reductase	0.1042	0.4017	0.4017
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/CSK protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Brugia malayi	Receptor family ligand binding region containing protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Trypanosoma brucei	protein kinase, putative	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Echinococcus granulosus	natriuretic peptide receptor 1	0.051	0.1844	0.1844
Plasmodium falciparum	protein kinase, putative	0.051	0.1844	0.1964
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Echinococcus multilocularis	FL cytokine receptor	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	Domain of unknown function DUF21, putative	0.0149	0.037	0.037
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.119	0.4625	0.4418
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trypanosoma cruzi	chloride channel protein, putative	0.0149	0.037	0.037
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.2506	1	1
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase Blk	0.051	0.1844	0.1844
Entamoeba histolytica	ankyrin repeat protein	0.051	0.1844	0.8859
Giardia lamblia	Kinase, NEK	0.051	0.1844	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Leishmania major	hypothetical protein, conserved	0.0149	0.037	0.037
Echinococcus granulosus	epidermal growth factor receptor	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Echinococcus multilocularis	protein kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Trichomonas vaginalis	CAMK family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	H(+):Cl() exchange transporter 3	0.0149	0.037	0.037
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Entamoeba histolytica	tyrosin kinase, putative	0.051	0.1844	0.8859
Trypanosoma cruzi	chloride channel protein, putative	0.0149	0.037	0.037
Chlamydia trachomatis	CBS domain-containing protein	0.0149	0.037	0.5
Onchocerca volvulus	Putative GMP reductase	0.1042	0.4017	1
Toxoplasma gondii	protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.051	0.1844	0.1844
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	chloride channel protein	0.0149	0.037	0.037
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trypanosoma cruzi	chloride channel protein, putative	0.0149	0.037	0.037
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	tyrosine protein kinase Src64B	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.051	0.1844	0.1844
Treponema pallidum	Mg2+ transport protein (mgtE)	0.0149	0.037	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Entamoeba histolytica	serine/threonine kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.051	0.1844	0.1844
Echinococcus multilocularis	integrin linked protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	TK/ABL protein kinase	0.051	0.1844	0.1844
Brugia malayi	integrin-linked kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	epidermal growth factor receptor	0.051	0.1844	0.1844
Loa Loa (eye worm)	chloride channel protein 7	0.0149	0.037	0.037
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Schistosoma mansoni	protein kinase subunit gamma	0.0149	0.037	0.037
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.2506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0149	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Brugia malayi	Furin-like cysteine rich region family protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	IMP dehydrogenase 1	0.2506	1	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.051	0.1844	0.1844
Brugia malayi	SH2 domain containing protein	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	serine/threonine kinase, putative	0.051	0.1844	0.8859
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein, conserved	0.051	0.1844	0.8859
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.2506	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Echinococcus granulosus	activated cdc42 kinase 1	0.051	0.1844	0.1844
Leishmania major	protein kinase, putative	0.051	0.1844	0.1844
Plasmodium falciparum	tyrosine kinase-like protein	0.051	0.1844	0.1964
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.2506	1	1
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Trichomonas vaginalis	conserved hypothetical protein	0.051	0.1844	1
Toxoplasma gondii	CBS domain-containing protein	0.0149	0.037	0.037
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.051	0.1844	0.1844
Entamoeba histolytica	hypothetical protein	0.051	0.1844	0.8859
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	tyrosine protein kinase Lyn	0.051	0.1844	0.1844
Brugia malayi	Raf kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase shark	0.051	0.1844	0.1844
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.2506	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.051	0.1844	0.1844
Giardia lamblia	Hypothetical protein	0.0149	0.037	0.2009
Onchocerca volvulus		0.051	0.1844	0.4591
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/ALK protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Onchocerca volvulus		0.051	0.1844	0.4591
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosine kinase, putative	0.051	0.1844	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Schistosoma mansoni	protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Trypanosoma cruzi	GMP reductase	0.2506	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.051	0.1844	0.1844
Loa Loa (eye worm)	TK/EGFR protein kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase, putative	0.051	0.1844	0.8859
Brugia malayi	Tyrosine-protein kinase abl-1	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Chlamydia trachomatis	GutQ/KpsF family sugar-phosphate isomerase	0.0149	0.037	0.5
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus granulosus	integrin linked protein kinase	0.051	0.1844	0.1844
Plasmodium falciparum	tyrosine kinase-like protein	0.051	0.1844	0.1964
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Echinococcus granulosus	tyrosine protein kinase csk	0.051	0.1844	0.1844
Entamoeba histolytica	tyrosin kinase, putative	0.051	0.1844	0.8859
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.051	0.1844	0.1844
Brugia malayi	Protein kinase domain containing protein	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.051	0.1844	0.1844
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.051	0.1844	0.1844
Loa Loa (eye worm)	RGC/RGC protein kinase	0.051	0.1844	0.1844
Schistosoma mansoni	tyrosine kinase	0.051	0.1844	0.1844
Entamoeba histolytica	serine/threonine kinase, putative	0.051	0.1844	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.051	0.1844	0.1844
Echinococcus granulosus	tyrosine protein kinase Src42A	0.051	0.1844	0.1844
Brugia malayi	hypothetical protein	0.051	0.1844	0.1844
Entamoeba histolytica	protein kinase domain containing protein	0.051	0.1844	0.8859
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.051	0.1844	0.1844
Brugia malayi	Voltage gated chloride channel family protein	0.0149	0.037	0.037
Trichomonas vaginalis	TKL family protein kinase	0.051	0.1844	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.051	0.1844	0.1844
Echinococcus granulosus	receptor type guanylyl cyclase	0.051	0.1844	0.1844
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Loa Loa (eye worm)	hypothetical protein	0.051	0.1844	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0149	0.037	0.037
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.051	0.1844	0.8859
Echinococcus multilocularis	activated cdc42 kinase 1	0.051	0.1844	0.1844

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.233 ug ml-1	Antifungal activity against Candida albicans CA980001 by alamar blue assay	ChEMBL.	17482460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3085361

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1817326