Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0892 | 0.1445 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0892 | 0.1445 | 0.1425 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.0356 | 0.0333 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.036 | 0.048 | 0.0128 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0892 | 0.1445 | 0.1425 |
Schistosoma mansoni | nicalin (M28 family) | 0.0892 | 0.1445 | 0.1425 |
Echinococcus granulosus | snurportin 1 | 0.036 | 0.048 | 0.0457 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.5603 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0892 | 0.1445 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.5603 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0892 | 0.1445 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0186 | 0.0163 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0892 | 0.1445 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.1445 | 0.1129 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0892 | 0.1445 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0892 | 0.1445 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.036 | 0.048 | 0.0457 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0892 | 0.1445 | 0.1425 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0475 | 0.0689 | 0.0667 |
Brugia malayi | nicalin | 0.0892 | 0.1445 | 0.1445 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.5603 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0892 | 0.1445 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0186 | 0.0163 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0892 | 0.1445 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5603 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0892 | 0.1445 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.5603 | 1 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0892 | 0.1445 | 0.1129 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0892 | 0.1445 | 0.1425 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0892 | 0.1445 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.0356 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.1445 | 0.1129 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0892 | 0.1445 | 0.1129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0892 | 0.1445 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0892 | 0.1445 | 0.1129 |
Mycobacterium tuberculosis | Conserved protein | 0.0892 | 0.1445 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.0356 | 0.0333 |
Brugia malayi | FXNA | 0.0892 | 0.1445 | 0.1445 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0892 | 0.1445 | 0.1129 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.0356 | 0.0333 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0892 | 0.1445 | 0.1425 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0892 | 0.1445 | 0.5 |
Echinococcus multilocularis | geminin | 0.0198 | 0.0186 | 0.0163 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.0356 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0892 | 0.1445 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0892 | 0.1445 | 0.1425 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.1445 | 0.1129 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0892 | 0.1445 | 0.1425 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.0356 | 0.0356 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0892 | 0.1445 | 0.1425 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0892 | 0.1445 | 0.5 |
Onchocerca volvulus | 0.0892 | 0.1445 | 0.1129 | |
Echinococcus granulosus | geminin | 0.0198 | 0.0186 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.1445 | 0.1129 |
Brugia malayi | leucyl aminopeptidase | 0.0892 | 0.1445 | 0.1445 |
Echinococcus multilocularis | snurportin 1 | 0.036 | 0.048 | 0.0457 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Stabilty (ADMET) | = 100 % | Metabolic stability in human plasma assessed as compound remaining after 1 hr by radio-HPLC analysis | ChEMBL. | 24262882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.