Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.016 | 0.016 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0297 | 0.0297 |
Toxoplasma gondii | hypothetical protein | 0.0075 | 0.0953 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0108 | 0.1726 | 0.1726 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0075 | 0.0953 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.004 | 0.016 | 0.016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0075 | 0.0953 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0075 | 0.0953 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0075 | 0.0953 | 0.0953 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0241 | 0.4778 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0953 | 0.0953 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0075 | 0.0953 | 0.0953 |
Brugia malayi | jmjC domain containing protein | 0.004 | 0.016 | 0.016 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0075 | 0.0953 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.0953 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0108 | 0.1726 | 0.1726 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0075 | 0.0953 | 0.0953 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.004 | 0.016 | 0.016 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0075 | 0.0953 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0075 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0953 | 0.0953 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0075 | 0.0953 | 0.0953 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0075 | 0.0953 | 0.0953 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0075 | 0.0953 | 0.0953 |
Schistosoma mansoni | nicalin (M28 family) | 0.0075 | 0.0953 | 0.0953 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0075 | 0.0953 | 0.0953 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0469 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0075 | 0.0953 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0075 | 0.0953 | 0.0953 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.016 | 0.016 |
Brugia malayi | leucyl aminopeptidase | 0.0075 | 0.0953 | 0.0953 |
Brugia malayi | FXNA | 0.0075 | 0.0953 | 0.0953 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0953 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0469 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0953 | 0.0953 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0075 | 0.0953 | 0.0953 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0297 | 0.0297 |
Brugia malayi | jmjC domain containing protein | 0.0108 | 0.1726 | 0.1726 |
Onchocerca volvulus | 0.0075 | 0.0953 | 0.0953 | |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 1 | 1 |
Brugia malayi | nicalin | 0.0075 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.0808 | 0.0808 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0075 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0075 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0953 | 0.0953 |
Schistosoma mansoni | jumonji domain containing protein | 0.0086 | 0.1216 | 0.1216 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.004 | 0.016 | 0.016 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0241 | 0.4778 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0075 | 0.0953 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0469 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0241 | 0.4778 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0241 | 0.4778 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0469 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Inhibition of rat kidney NADPH-dependent aldose reductase assessed as DL-glyceraldehyde conversion to glycerol at 1 uM preincubated for 20 mins followed by NADPH addition measured after 5 mins by UV-Visible spectrophotometric analysis relative to control | ChEMBL. | 24275248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.