Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.1238 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0908 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.1238 | 1 | 1 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0197 | 0.0908 | 0.0908 |
Brugia malayi | nicalin | 0.0197 | 0.0908 | 0.0908 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.1238 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0197 | 0.0908 | 0.0908 |
Leishmania major | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.1238 | 1 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0093 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0197 | 0.0908 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0197 | 0.0908 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.1238 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0197 | 0.0908 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0197 | 0.0908 | 0.0908 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0197 | 0.0908 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0908 | 1 |
Brugia malayi | FXNA | 0.0197 | 0.0908 | 0.0908 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0197 | 0.0908 | 0.0908 |
Mycobacterium ulcerans | hypothetical protein | 0.0197 | 0.0908 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0197 | 0.0908 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0197 | 0.0908 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0197 | 0.0908 | 1 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0197 | 0.0908 | 0.0908 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.01 uM | Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) | ChEMBL. | 10780917 |
EC50 (functional) | = 0.08 uM | Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) | ChEMBL. | 10780917 |
Inhibition (functional) | = 54 % | Cell Cycle inhibition against mouse lymphocytic leukemia cells (L1210) at 10 microM | ChEMBL. | 10780917 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10780917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.