Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | C-C chemokine receptor type 1 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.00063 uM | Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis | ChEMBL. | 24332486 |
IC50 (binding) | = 0.101 uM | Displacement of [125I]MIP-1alpha from rat CCR1 | ChEMBL. | 24332486 |
IC50 (binding) | = 3.8 uM | Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology | ChEMBL. | 24332486 |
permeability (ADMET) | = 0.93 ucm/s | Permeability across human Caco2 cells | ChEMBL. | 24332486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.