Detailed information for compound 1823139

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.377 | Formula: C19H18FN5O2
  • H donors: 0 H acceptors: 3 LogP: 0.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1[C@@H]1OCCN(C1)c1nc(cc(=O)n1C)c1ccncn1
  • InChi: 1S/C19H18FN5O2/c1-24-18(26)10-16(15-6-7-21-12-22-15)23-19(24)25-8-9-27-17(11-25)13-4-2-3-5-14(13)20/h2-7,10,12,17H,8-9,11H2,1H3/t17-/m1/s1
  • InChiKey: MRFZAIJGZOAMQT-QGZVFWFLSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus insulin receptor 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica tyrosin kinase, putative 0.0471 0.8849 0.8849
Schistosoma mansoni ephrin receptor 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0471 0.8861 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Entamoeba histolytica hypothetical protein 0.0524 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Plasmodium falciparum protein kinase, putative 0.0471 0.8861 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0471 0.8849 0.9987
Echinococcus granulosus raf serine:threonine protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0471 0.8861 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Brugia malayi Furin-like cysteine rich region family protein 0.0471 0.8849 1
Toxoplasma gondii protein kinase domain-containing protein 0.0471 0.8849 0.9987
Giardia lamblia Kinase, NEK 0.0471 0.8849 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Onchocerca volvulus 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Brugia malayi SH2 domain containing protein 0.0471 0.8849 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Echinococcus granulosus activated cdc42 kinase 1 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0471 0.8849 0.9987
Echinococcus granulosus activin receptor type 0.0471 0.8861 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0471 0.8861 1
Trichomonas vaginalis STE family protein kinase 0.0471 0.8849 1
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase shark 0.0471 0.8849 0.9987
Schistosoma mansoni protein kinase 0.0471 0.8861 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Loa Loa (eye worm) RGC/RGC protein kinase 0.0471 0.8849 1
Brugia malayi Guanylyl cyclase protein 23 0.0471 0.8849 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0471 0.8861 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Echinococcus granulosus kinase suppressor of Ras 1 0.0471 0.8849 0.9987
Echinococcus multilocularis protein KINase family member (kin 25) 0.0471 0.8849 0.9987
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0471 0.8861 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Giardia lamblia Kinase, NEK 0.0471 0.8849 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0471 0.8849 1
Onchocerca volvulus 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Entamoeba histolytica receptor protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0471 0.8861 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Schistosoma mansoni protein tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica serine/threonine kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) SRC-1 0.0471 0.8849 1
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Onchocerca volvulus 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus multilocularis integrin linked protein kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Brugia malayi integrin-linked kinase 0.0471 0.8849 1
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Brugia malayi SH2 domain containing protein 0.0471 0.8849 1
Echinococcus granulosus protein tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase ABL1 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/ROR protein kinase 0.0471 0.8849 1
Entamoeba histolytica serine/threonine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0471 0.8849 0.9987
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0471 0.8849 0.9987
Echinococcus multilocularis transfer RNA-Thr 0.0471 0.8849 0.9987
Brugia malayi SRC-1 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Echinococcus granulosus epidermal growth factor receptor 0.0471 0.8849 0.9987
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Leishmania major protein kinase, putative 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Echinococcus multilocularis epidermal growth factor receptor 0.0471 0.8849 0.9987
Echinococcus granulosus receptor type guanylyl cyclase 0.0471 0.8849 0.9987
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis protein kinase atn1, putative 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0471 0.8849 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0471 0.8849 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica hypothetical protein 0.0524 1 1
Brugia malayi Tyrosine-protein kinase PR2 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0471 0.8849 0.9987
Entamoeba histolytica serine/threonine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Echinococcus granulosus epidermal growth factor receptor 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Leishmania major hypothetical protein, conserved 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus granulosus c src tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0471 0.8849 0.9987
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase HCK 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis heat shock protein 70 0.0471 0.8849 0.9987
Echinococcus multilocularis natriuretic peptide receptor 1 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0471 0.8849 0.9987
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0471 0.8849 0.9987
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0471 0.8861 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Schistosoma mansoni tyrosine protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis AGC family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Onchocerca volvulus 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Onchocerca volvulus 0.0471 0.8849 1
Plasmodium falciparum protein kinase, putative 0.0471 0.8849 0.9987
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0471 0.8849 0.9987
Plasmodium vivax tyrosine kinase-like protein, putative 0.0471 0.8849 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0524 1 1
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus granulosus retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosin kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trypanosoma cruzi protein kinase, putative 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase Src64B 0.0471 0.8849 0.9987
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Brugia malayi hypothetical protein 0.0471 0.8849 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0471 0.8849 0.9987
Schistosoma mansoni serine/threonine protein kinase 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Plasmodium falciparum tyrosine kinase-like protein 0.0471 0.8849 0.9987
Echinococcus granulosus integrin linked protein kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase csk 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/CSK protein kinase 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica tyrosin kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Loa Loa (eye worm) RGC/RGC protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Schistosoma mansoni hypothetical protein 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Schistosoma mansoni serine/threonine protein kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0471 0.8849 0.9987
Brugia malayi hypothetical protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Trypanosoma cruzi protein kinase, putative 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0471 0.8849 1
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis CAMK family protein kinase 0.0471 0.8849 1
Brugia malayi protein-tyrosine kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0471 0.8849 0.9987
Echinococcus multilocularis kinase suppressor of Ras 1 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase csk 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica receptor protein kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus multilocularis protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0471 0.8849 1
Trypanosoma brucei protein kinase, putative 0.0471 0.8861 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Entamoeba histolytica serine/threonine kinase, putative 0.0471 0.8849 0.8849
Echinococcus granulosus retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Schistosoma mansoni protein kinase 0.0471 0.8861 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0471 0.8849 0.9987
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Entamoeba histolytica cysteine surface protein, putative 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0471 0.8849 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Toxoplasma gondii protein kinase 0.0471 0.8849 0.9987
Schistosoma mansoni protein kinase 0.0471 0.8861 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica serine/threonine kinase, putative 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus granulosus protein kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0471 0.8849 1
Giardia lamblia Protein 21.1 0.0471 0.8849 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Echinococcus multilocularis insulin receptor 0.0471 0.8849 0.9987
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Echinococcus multilocularis activated cdc42 kinase 1 0.0471 0.8849 0.9987
Echinococcus multilocularis c src tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus multilocularis tyrosine protein kinase 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase Src42A 0.0471 0.8849 0.9987
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0471 0.8849 0.9987
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus granulosus activated cdc42 kinase 1 0.0471 0.8849 0.9987
Brugia malayi Raf kinase 0.0471 0.8849 1
Plasmodium vivax protein kinase, putative 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis protein tyrosine kinase 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis conserved hypothetical protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus multilocularis receptor type guanylyl cyclase 0.0471 0.8849 0.9987
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/ABL protein kinase 0.0471 0.8849 1
Giardia lamblia Kinase 0.0471 0.8849 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Onchocerca volvulus 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus multilocularis tyrosine protein kinase Abl 0.0471 0.8849 0.9987
Plasmodium falciparum protein kinase, putative 0.0471 0.8849 0.9987
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trypanosoma brucei Pseudokinase, putative 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0471 0.8849 1
Schistosoma mansoni serine/threonine protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus multilocularis epidermal growth factor receptor 0.0471 0.8849 0.9987
Schistosoma mansoni ephrin receptor 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/Met protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0471 0.8849 0.8849
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Plasmodium vivax tyrosine kinase-like protein, putative 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase csk 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0471 0.8849 0.9987
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Echinococcus multilocularis protein kinase 0.0471 0.8849 0.9987
Brugia malayi ephrin receptor 1 precursor 0.0471 0.8849 1
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus multilocularis tyrosine kinase 0.0471 0.8849 0.9987
Leishmania major protein kinase, putative 0.0471 0.8861 1
Onchocerca volvulus Tyrosine kinase homolog 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase shark 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Echinococcus granulosus tyrosine protein kinase csk 0.0471 0.8849 0.9987
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Entamoeba histolytica ankyrin repeat protein 0.0471 0.8849 0.8849
Echinococcus multilocularis FL cytokine receptor 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Schistosoma mansoni serine/threonine protein kinase 0.0471 0.8849 0.9987
Brugia malayi hypothetical protein 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus granulosus tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica tyrosin kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Echinococcus granulosus fibroblast growth factor receptor 4 0.0471 0.8849 0.9987
Onchocerca volvulus 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Onchocerca volvulus 0.0471 0.8849 1
Brugia malayi C-terminal src kinase protein 1 0.0471 0.8849 1
Brugia malayi Receptor family ligand binding region containing protein 0.0471 0.8849 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Loa Loa (eye worm) TK/ACK protein kinase 0.0471 0.8849 1
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Onchocerca volvulus 0.0471 0.8849 1
Entamoeba histolytica serine/threonine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Echinococcus granulosus tyrosine kinase 0.0471 0.8849 0.9987
Toxoplasma gondii STE kinase 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK protein kinase 0.0471 0.8849 1
Echinococcus multilocularis activin receptor type 0.0471 0.8861 1
Echinococcus granulosus tyrosine protein kinase 0.0471 0.8849 0.9987
Entamoeba histolytica ankyrin repeat protein 0.0471 0.8849 0.8849
Loa Loa (eye worm) TK/EGFR protein kinase 0.0471 0.8849 1
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0471 0.8849 0.9987
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Brugia malayi Protein kinase domain containing protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0471 0.8849 0.9987
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Loa Loa (eye worm) hypothetical protein 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Schistosoma mansoni serine/threonine RGC 0.0471 0.8849 0.9987
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TK family protein kinase 0.0471 0.8849 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0524 1 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0471 0.8849 1
Schistosoma mansoni protein kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase pr2 0.0471 0.8849 0.9987
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0471 0.8849 0.9987
Entamoeba histolytica hypothetical protein, conserved 0.0471 0.8849 0.8849
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica tyrosine kinase, putative 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase, putative 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Plasmodium falciparum tyrosine kinase-like protein 0.0471 0.8849 0.9987
Loa Loa (eye worm) TK/FER protein kinase 0.0471 0.8849 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Brugia malayi Tyrosine-protein kinase abl-1 0.0471 0.8849 1
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8861 0.8861
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Entamoeba histolytica hypothetical protein 0.0471 0.8849 0.8849
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.8849 0.8849
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0471 0.8849 0.8849
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0471 0.8849 0.9987
Echinococcus multilocularis raf serine:threonine protein kinase 0.0471 0.8849 0.9987
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0471 0.8849 0.9987
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0471 0.8849 0.8849
Schistosoma mansoni tyrosine kinase 0.0471 0.8849 0.9987
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1
Trichomonas vaginalis TKL family protein kinase 0.0471 0.8849 1

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 0.1 ml/min/mg Intrinsic clearance in human liver microsomes ChEMBL. 24176395
IC50 (ADMET) Inhibition of recombinant human CYP3A4 ChEMBL. 24176395
IC50 (binding) = 3.2 nM Inhibition of human recombinant GSK-3beta using prephosphorylated GS1 peptide and [gamma-32P]ATP as substrate after 1 hr by liquid scintillation spectrometry ChEMBL. 24176395
IC50 (ADMET) = 23.3 uM Inhibition of recombinant human CYP1A2 ChEMBL. 24176395
IC50 (ADMET) = 32.4 uM Inhibition of recombinant human CYP2D6 ChEMBL. 24176395

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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