Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | sonic hedgehog | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06224 hedgehog, putative | Get druggable targets OG5_131225 | All targets in OG5_131225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0539 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2252 | 0.1811 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0626 | 0.0626 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1201 | 0.1749 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1899 | 0.1437 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.6864 | 0.9996 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1201 | 0.1749 |
Brugia malayi | Hint module family protein | 0.0061 | 0.1899 | 0.1808 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0626 | 0.0626 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1737 | 0.1737 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.094 | 0.0423 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.6867 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.074 | 0.0212 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1277 | 0.1179 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1277 | 0.1179 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1277 | 0.0779 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1201 | 0.1102 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0539 | 0.0433 |
Onchocerca volvulus | 0.0047 | 0.1201 | 0.5 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0737 | 0.0633 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1737 | 0.1737 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.2452 | 0.2368 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1277 | 0.0779 |
Echinococcus granulosus | Desert hedgehog protein | 0.0226 | 0.9817 | 0.9817 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.085 | 0.0329 |
Brugia malayi | Hint module family protein | 0.0061 | 0.1899 | 0.1808 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1899 | 0.1437 |
Echinococcus multilocularis | geminin | 0.0165 | 0.6867 | 0.6867 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.1904 | 0.2773 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.6867 | 1 |
Echinococcus multilocularis | hedgehog | 0.0226 | 0.9817 | 0.9817 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.6867 | 0.6867 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 500 nM | Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay | ChEMBL. | 24176396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.