Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0414 | 0.207 | 0.2788 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0426 | 0.2193 | 0.273 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0961 | 0.7424 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0206 | 0.0043 | 0.0058 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0637 | 0.4253 | 0.5729 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0961 | 0.7424 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0516 | 0.3075 | 0.4142 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0961 | 0.7424 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0614 | 0.4028 | 0.3993 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0677 | 0.4645 | 0.6257 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium ulcerans | thioesterase | 0.0548 | 0.3379 | 0.4551 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0677 | 0.4645 | 0.6257 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0614 | 0.4028 | 0.5426 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0636 | 0.4246 | 0.5719 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0636 | 0.4246 | 0.4246 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0548 | 0.3379 | 0.452 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0508 | 0.2991 | 0.4028 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0414 | 0.207 | 0.2746 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0206 | 0.0043 | 0.0058 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0636 | 0.4246 | 0.5694 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0637 | 0.4253 | 0.5729 |
Brugia malayi | AMP-binding enzyme family protein | 0.0614 | 0.4028 | 0.4028 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0468 | 0.2599 | 0.3933 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0677 | 0.4645 | 0.6235 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0205 | 0.0029 | 0.0039 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0677 | 0.4645 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0472 | 0.264 | 0.3556 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0677 | 0.4645 | 0.6257 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0961 | 0.7424 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0677 | 0.4645 | 0.6235 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0636 | 0.4246 | 0.5694 |
Loa Loa (eye worm) | hypothetical protein | 0.1083 | 0.8615 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0677 | 0.4645 | 0.6235 |
Mycobacterium ulcerans | thioesterase TesA | 0.0548 | 0.3379 | 0.4551 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0414 | 0.207 | 0.2788 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0508 | 0.2991 | 0.3993 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0508 | 0.2991 | 0.4028 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0677 | 0.4645 | 0.6257 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0677 | 0.4645 | 0.6257 |
Mycobacterium ulcerans | polyketide synthase | 0.0636 | 0.4246 | 0.5719 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0548 | 0.3379 | 0.4551 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0266 | 0.0623 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.142 | 0.0578 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1184 | 0.9608 | 1 |
Onchocerca volvulus | 0.1144 | 0.9209 | 0.9285 | |
Loa Loa (eye worm) | fatty acid synthase | 0.0648 | 0.4365 | 0.4434 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0374 | 0.1678 | 0.226 |
Mycobacterium ulcerans | polyketide synthase | 0.0677 | 0.4645 | 0.6257 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of TLR4 in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by LPS challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-6 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR9 in BALB/c mouse BMDM assessed as downregulation of CpG-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by CpG challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 | |
Inhibition (binding) | Inhibition of TLR4 in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated IL-6 level at 5 ug/ml preincubated for 18 hrs followed by LPS challenge measured after 24 hrs by ELISA relative to control | ChEMBL. | 24228757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.