Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | anaplastic lymphoma receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | TK/ALK protein kinase | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0554 | 0.0941 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0554 | 0.0941 | 0.5 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0285 | 0.0109 | 0.0109 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0554 | 0.0941 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.0941 | 0.0941 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0554 | 0.0941 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0554 | 0.0941 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0554 | 0.0941 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0554 | 0.0941 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.348 | 1 | 1 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0554 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.348 | 1 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.348 | 1 | 1 |
Brugia malayi | nicalin | 0.0554 | 0.0941 | 0.084 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0554 | 0.0941 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0554 | 0.0941 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0554 | 0.0941 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.348 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0554 | 0.0941 | 0.5 |
Brugia malayi | FXNA | 0.0554 | 0.0941 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.0941 | 0.0941 |
Toxoplasma gondii | hypothetical protein | 0.0554 | 0.0941 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0554 | 0.0941 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0554 | 0.0941 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.348 | 1 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0554 | 0.0941 | 0.084 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0554 | 0.0941 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL/F (ADMET) | = 49 ml/min.kg | Apparent total intrinsic clearance in human liver microsomes | ChEMBL. | 24432909 |
Ki (binding) | = 15 nM | Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus using 5'FAM-KKSRGDYMTMQIG-CONH2 as substrate incubated for 15 mins prior to Km levels of ATP addition measured after 1 hr by microfluidic mobility shift assay | ChEMBL. | 24432909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.