Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0228 | 0.1657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0959 | 0.0959 |
Plasmodium falciparum | perforin-like protein 4 | 0.0074 | 0.0516 | 0.5375 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0228 | 0.1657 | 0.1657 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0801 | 0.5932 | 0.5932 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0959 | 0.0959 |
Plasmodium falciparum | perforin-like protein 3 | 0.0074 | 0.0516 | 0.5375 |
Brugia malayi | Carboxylesterase family protein | 0.0228 | 0.1657 | 0.1657 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Echinococcus granulosus | acetylcholinesterase | 0.1347 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0228 | 0.1657 | 0.1657 |
Loa Loa (eye worm) | hypothetical protein | 0.1347 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0228 | 0.1657 | 0.1657 |
Plasmodium vivax | perforin-like protein 2 | 0.0074 | 0.0516 | 0.5375 |
Echinococcus granulosus | RUN | 0.0134 | 0.0959 | 0.0959 |
Brugia malayi | Carboxylesterase family protein | 0.0228 | 0.1657 | 0.1657 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0005 | 0 | 0.5 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0005 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1347 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0228 | 0.1657 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0134 | 0.0959 | 0.0959 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0228 | 0.1657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1347 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Plasmodium vivax | perforin-like protein 3 | 0.0074 | 0.0516 | 0.5375 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0005 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0134 | 0.0959 | 0.0959 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Plasmodium vivax | perforin-like protein 4 | 0.0074 | 0.0516 | 0.5375 |
Onchocerca volvulus | 0.0228 | 0.1657 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Schistosoma mansoni | rab6-interacting | 0.0134 | 0.0959 | 0.0959 |
Schistosoma mansoni | acetylcholinesterase | 0.0228 | 0.1657 | 0.1657 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0801 | 0.5932 | 0.5932 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1347 | 1 | 1 |
Echinococcus granulosus | macrophage expressed protein | 0.0673 | 0.4977 | 0.4977 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0134 | 0.0959 | 0.0959 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0134 | 0.0959 | 1 |
Brugia malayi | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Brugia malayi | hypothetical protein | 0.0134 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Loa Loa (eye worm) | carboxylesterase | 0.0228 | 0.1657 | 0.1657 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0134 | 0.0959 | 0.0959 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0228 | 0.1657 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0134 | 0.0959 | 0.0959 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0134 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | doublecortin family protein | 0.0134 | 0.0959 | 0.0959 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0228 | 0.1657 | 0.1657 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0134 | 0.0959 | 0.0959 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0801 | 0.5932 | 0.5932 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Plasmodium falciparum | perforin-like protein 1 | 0.0074 | 0.0516 | 0.5375 |
Schistosoma mansoni | loxhd1 | 0.0134 | 0.0959 | 0.0959 |
Leishmania major | p-glycoprotein | 0.0005 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0228 | 0.1657 | 0.1657 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Brugia malayi | Doublecortin family protein | 0.0134 | 0.0959 | 0.0959 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0228 | 0.1657 | 0.1657 |
Echinococcus granulosus | carboxylesterase 5A | 0.1347 | 1 | 1 |
Onchocerca volvulus | 0.0228 | 0.1657 | 1 | |
Plasmodium vivax | perforin-like protein 5 | 0.0074 | 0.0516 | 0.5375 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0134 | 0.0959 | 0.0959 |
Onchocerca volvulus | 0.0228 | 0.1657 | 1 | |
Onchocerca volvulus | 0.0228 | 0.1657 | 1 | |
Entamoeba histolytica | P-glycoprotein-2 | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1347 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Onchocerca volvulus | 0.0134 | 0.0959 | 0.5788 | |
Loa Loa (eye worm) | carboxylesterase | 0.0228 | 0.1657 | 0.1657 |
Echinococcus multilocularis | acetylcholinesterase | 0.1347 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Onchocerca volvulus | 0.0228 | 0.1657 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Plasmodium falciparum | perforin-like protein 5 | 0.0074 | 0.0516 | 0.5375 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0074 | 0.0516 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1347 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1347 | 1 | 1 |
Echinococcus multilocularis | macrophage expressed protein | 0.0673 | 0.4977 | 0.4977 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1347 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1347 | 1 | 1 |
Plasmodium falciparum | perforin-like protein 2 | 0.0074 | 0.0516 | 0.5375 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0228 | 0.1657 | 0.1657 |
Plasmodium vivax | perforin-like protein 1 | 0.0074 | 0.0516 | 0.5375 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0959 | 0.0959 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0005 | 0 | 0.5 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0005 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0228 | 0.1657 | 0.5 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.0005 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0228 | 0.1657 | 0.1657 |
Echinococcus granulosus | neuroligin | 0.0228 | 0.1657 | 0.1657 |
Schistosoma mansoni | lipoxygenase | 0.056 | 0.4135 | 0.4135 |
Echinococcus multilocularis | RUN | 0.0134 | 0.0959 | 0.0959 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0134 | 0.0959 | 1 |
Onchocerca volvulus | 0.0134 | 0.0959 | 0.5788 | |
Schistosoma mansoni | polycystin 1-related | 0.0134 | 0.0959 | 0.0959 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0074 | 0.0516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1657 | 0.1657 |
Chlamydia trachomatis | hypothetical protein | 0.0074 | 0.0516 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0673 | 0.4977 | 0.4977 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0228 | 0.1657 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0228 | 0.1657 | 0.1657 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Beta2 duration (functional) | > 180 min | In vitro beta2 duration was determined using electrically stimulated guinea-pig isolated trachea superfusion system | ChEMBL. | 12852752 |
Beta2 duration (functional) | > 180 min | In vitro beta2 duration was determined using electrically stimulated guinea-pig isolated trachea superfusion system | ChEMBL. | 12852752 |
Intrinsic activity (functional) | = 0.55 | Intrinsic agonist activity was determined in rings of guinea-pig isolated trachea | ChEMBL. | 12852752 |
logD (ADMET) | = 2.54 | Partition coefficient (logD7.4) | ChEMBL. | 12852752 |
pKa | > 8 | Ionization constant (pKa) | ChEMBL. | 12852752 |
p[A]50 (functional) | = 7.73 | Beta2-adrenoceptor potency was determined in rings of guinea-pig isolated trachea | ChEMBL. | 12852752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.