Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0229 | 0.1208 | 0.1226 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1663 | 0.9853 | 0.9853 |
Onchocerca volvulus | 0.0229 | 0.1208 | 0.9805 | |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1663 | 0.9853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1208 | 0.1226 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0229 | 0.1208 | 0.1226 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1663 | 0.9853 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1688 | 1 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1663 | 0.9853 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1663 | 0.9853 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1663 | 0.9853 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0229 | 0.1208 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.1208 | 0.1226 |
Trichomonas vaginalis | immunophilin, putative | 0.1663 | 0.9853 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0229 | 0.1208 | 0.1226 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0229 | 0.1208 | 0.1208 |
Leishmania major | fk506-binding protein 1-like protein | 0.1663 | 0.9853 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0229 | 0.1208 | 0.1226 |
Echinococcus multilocularis | fk506 binding protein | 0.1663 | 0.9853 | 0.9853 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1459 | 0.8621 | 0.8621 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0229 | 0.1208 | 0.1226 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1663 | 0.9853 | 0.9853 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0229 | 0.1208 | 0.5 |
Schistosoma mansoni | fk506 binding protein | 0.0229 | 0.1208 | 0.1208 |
Schistosoma mansoni | immunophilin | 0.1688 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.1208 | 0.1226 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0229 | 0.1208 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1667 | 0.9877 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0229 | 0.1208 | 0.5 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1208 | 0.1226 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1663 | 0.9853 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0229 | 0.1208 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0229 | 0.1208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1438 | 0.8498 | 0.8625 |
Onchocerca volvulus | 0.0233 | 0.1232 | 1 | |
Loa Loa (eye worm) | FKBP5 protein | 0.1663 | 0.9853 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1663 | 0.9853 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0229 | 0.1208 | 0.1226 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0229 | 0.1208 | 0.1226 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0253 | 0.1355 | 0.1355 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1663 | 0.9853 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1688 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1688 | 1 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0229 | 0.1208 | 0.1226 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0229 | 0.1208 | 0.1226 |
Schistosoma mansoni | immunophilin | 0.1459 | 0.8621 | 0.8621 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0229 | 0.1208 | 0.1208 |
Schistosoma mansoni | immunophilin | 0.1688 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1208 | 0.1226 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1663 | 0.9853 | 1 |
Echinococcus multilocularis | 0.0229 | 0.1208 | 0.1208 | |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0229 | 0.1208 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1663 | 0.9853 | 0.9972 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1459 | 0.8621 | 0.8621 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.1208 | 0.1208 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1663 | 0.9853 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0229 | 0.1208 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0229 | 0.1208 | 0.1226 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0229 | 0.1208 | 0.1226 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0229 | 0.1208 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1663 | 0.9853 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.59 uM | Vasorelaxant activity against isolated vascular ring preparation from rabbit thoracic aorta | ChEMBL. | 1956043 |
k (ADMET) | = 5 s-1 | Rate constant of the compound for loss of chromophore | ChEMBL. | 1956043 |
Rm (functional) | = 74 % | Peak relaxation(Rm) of the vascular ring by the compound at highest concentration | ChEMBL. | 1956043 |
T1/2 (ADMET) | = 2.3 min | Half-life of the compound was determined | ChEMBL. | 1956043 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.