Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Aldose reductase | 0.0103 | 0.2311 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0048 | 0.0042 | 0.0056 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0103 | 0.2311 | 0.1759 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0101 | 0.2228 | 0.2981 |
Entamoeba histolytica | aldose reductase, putative | 0.0103 | 0.2311 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0276 | 0.9416 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0128 | 0.3311 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0153 | 0.4361 | 0.581 |
Mycobacterium ulcerans | thioesterase | 0.0128 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0149 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0048 | 0.0042 | 0.0056 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0103 | 0.2311 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0153 | 0.4361 | 0.581 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0103 | 0.2311 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0103 | 0.2311 | 0.3053 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0153 | 0.4361 | 0.4361 |
Echinococcus granulosus | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0103 | 0.2311 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0143 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0123 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0163 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | oxidoreductase | 0.0103 | 0.2311 | 0.1759 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0103 | 0.2311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.8643 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0053 | 0.0229 | 0.0306 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0123 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | polyketide synthase | 0.0163 | 0.4752 | 0.6357 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0099 | 0.2149 | 0.2574 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0143 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0153 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0229 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0128 | 0.3311 | 0.443 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1592 | 0.0823 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0073 | 0.1081 | 0.1398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0062 | 0.061 | 0.0817 |
Loa Loa (eye worm) | fatty acid synthase | 0.0151 | 0.4277 | 0.4318 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0103 | 0.2311 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0103 | 0.2311 | 0.2311 |
Brugia malayi | AMP-binding enzyme family protein | 0.0143 | 0.3948 | 0.3948 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0153 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0153 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0163 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4361 | 0.5834 |
Trypanosoma brucei | prostaglandin f synthase | 0.0103 | 0.2311 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0163 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | oxidoreductase | 0.0103 | 0.2311 | 0.1759 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0103 | 0.2311 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0103 | 0.2311 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0229 | 0.7476 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0103 | 0.2311 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0087 | 0.1644 | 0.2199 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0125 | 0.3214 | 0.4299 |
Onchocerca volvulus | 0.0143 | 0.3948 | 0.2303 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0103 | 0.2311 | 0.2311 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0103 | 0.2311 | 0.3092 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0101 | 0.2228 | 0.2941 |
Echinococcus granulosus | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0103 | 0.2311 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0103 | 0.2311 | 0.3038 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0149 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0101 | 0.2228 | 0.2981 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0163 | 0.4752 | 0.6337 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.011 | 0.2588 | 0.3461 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Schistosoma mansoni | pol-related | 0.0103 | 0.2311 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0103 | 0.2311 | 0.2311 |
Echinococcus multilocularis | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0123 | 0.3131 | 0.4155 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0103 | 0.2311 | 0.2311 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0229 | 0.7476 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0109 | 0.2547 | 0.3708 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0163 | 0.4752 | 0.6357 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0153 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0163 | 0.4752 | 0.6337 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0128 | 0.3311 | 0.4398 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0163 | 0.4752 | 0.6337 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0103 | 0.2311 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0153 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | oxidoreductase | 0.0103 | 0.2311 | 0.1759 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2311 | 0.1759 |
Echinococcus granulosus | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0103 | 0.2311 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0103 | 0.2311 | 0.1759 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0163 | 0.4752 | 0.6357 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0163 | 0.4752 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0103 | 0.2311 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0103 | 0.2311 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0103 | 0.2311 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0229 | 0.7476 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0103 | 0.2311 | 0.3092 |
Onchocerca volvulus | 0.0267 | 0.9025 | 0.9449 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0103 | 0.2311 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0103 | 0.2311 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.