Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | glucokinase | Starlite/ChEMBL | References |
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Brugia malayi | Hexokinase family protein | glucokinase | 465 aa | 473 aa | 29.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK protein kinase | 0.0109 | 0.5011 | 0.5011 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0168 | 0.8565 | 0.8565 |
Echinococcus granulosus | roundabout 2 | 0.003 | 0.0327 | 0.0327 |
Onchocerca volvulus | 0.0142 | 0.6981 | 0.2936 | |
Brugia malayi | Hexokinase family protein | 0.0121 | 0.5727 | 0.4604 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0103 | 0.4684 | 0.4684 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0103 | 0.4684 | 0.4608 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0109 | 0.5011 | 0.37 |
Brugia malayi | hexokinase type II | 0.0061 | 0.2179 | 0.0123 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.2081 | 0.2081 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2179 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2179 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6354 | 0.6354 |
Echinococcus granulosus | twitchin | 0.0027 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | hexokinase | 0.0121 | 0.5727 | 0.5727 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0103 | 0.4684 | 0.4684 |
Schistosoma mansoni | nephrin | 0.0027 | 0.0142 | 0.0142 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0103 | 0.4684 | 0.4608 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0327 | 0.0327 |
Schistosoma mansoni | tyrosine kinase | 0.0103 | 0.4684 | 0.4684 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0168 | 0.8565 | 0.8188 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0149 | 0.7425 | 0.3974 |
Echinococcus granulosus | neuroglian | 0.0027 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0327 | 0.0327 |
Echinococcus multilocularis | roundabout 2 | 0.003 | 0.0327 | 0.0188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 12.5 uM | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | ChEMBL. | 24405213 |
IC50 (binding) | = 0.324 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by Alpha Screen assay | ChEMBL. | 24405213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.