Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | zinc finger protein | 0.0045 | 0.0424 | 0.0891 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.302 | 0.6345 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0106 | 0.302 | 0.6727 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0041 | 0.0235 | 0.0062 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.004 | 0.0174 | 0.0366 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0106 | 0.302 | 0.2896 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0106 | 0.302 | 0.2284 |
Brugia malayi | Bromodomain containing protein | 0.0089 | 0.2282 | 0.1468 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.004 | 0.0174 | 0.0366 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0052 | 0.0719 | 0.1287 |
Brugia malayi | Bromodomain containing protein | 0.0174 | 0.5922 | 0.5492 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0106 | 0.302 | 0.6727 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2713 | 0.2584 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0138 | 0.4405 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0045 | 0.0424 | 0.0592 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.302 | 0.6345 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0052 | 0.0719 | 0.1287 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.004 | 0.0174 | 0.0366 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0048 | 0.0529 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2289 | 0.2152 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0083 | 0.2047 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.2523 | 0.2391 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0106 | 0.302 | 0.6727 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0138 | 0.4405 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.004 | 0.0174 | 0.0366 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0529 | 0.1112 |
Echinococcus multilocularis | zinc finger protein | 0.0045 | 0.0424 | 0.0592 |
Schistosoma mansoni | bromodomain containing protein | 0.0147 | 0.476 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0052 | 0.0719 | 0.151 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0106 | 0.302 | 0.6727 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5498 | 0.5418 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.302 | 0.6345 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0083 | 0.2047 | 0.4427 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 20 uM | Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay | ChEMBL. | 24144213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.