TDR Targets

Basic information

Technical information

TDR Targets ID: 1836338
Name: methyl (2R)-3-(1H-indol-3-yl)-2-[[2-(1H-indol -3-yl)-2-oxoacetyl]amino]propanoate
MW: 389.404 | Formula: C22H19N3O4
H donors: 3 H acceptors: 3 LogP: 3.25 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@H](NC(=O)C(=O)c1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2
InChi: 1S/C22H19N3O4/c1-29-22(28)19(10-13-11-23-17-8-4-2-6-14(13)17)25-21(27)20(26)16-12-24-18-9-5-3-7-15(16)18/h2-9,11-12,19,23-24H,10H2,1H3,(H,25,27)/t19-/m1/s1
InChiKey: HIFDOUATSGPYEI-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl (2R)-3-(1H-indol-3-yl)-2-[[2-(1H-indol-3-yl)-2-oxo-acetyl]amino]propanoate
(2R)-3-(1H-indol-3-yl)-2-[[2-(1H-indol-3-yl)-1,2-dioxoethyl]amino]propanoic acid methyl ester
(2R)-3-(1H-indol-3-yl)-2-[[2-(1H-indol-3-yl)-2-keto-acetyl]amino]propionic acid methyl ester
methyl (2R)-3-(1H-indol-3-yl)-2-[[2-(1H-indol-3-yl)-2-oxo-ethanoyl]amino]propanoate
ZINC04163288

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0169	0.0664	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0052	0.0077	0.0066
Leishmania major	hypothetical protein, conserved	0.0169	0.0664	1
Schistosoma mansoni	lipoxygenase	0.0139	0.0515	0.049
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0169	0.0664	0.0726
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0077	0.0494
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0044	0.0037	0.0165
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0077	0.0066
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0099	0.0716
Echinococcus granulosus	carboxylesterase 5A	0.0078	0.0205	0.1163
Echinococcus granulosus	acetylcholinesterase	0.0078	0.0205	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0029	0.0018
Schistosoma mansoni	inositol monophosphatase	0.0044	0.0037	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0077	0.0066
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0169	0.0664	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0044	0.0037	0.5
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0029	0.0032
Echinococcus multilocularis	acetylcholinesterase	0.0078	0.0205	0.1163
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.0037	0.0066
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0029	0.0018
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0056	0.0096	0.0085
Schistosoma mansoni	fad oxidoreductase	0.0169	0.0664	0.064
Brugia malayi	cDNA sequence BC016226	0.0169	0.0664	0.6232
Toxoplasma gondii	hypothetical protein	0.0169	0.0664	1
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.1861	0.9151	1
Schistosoma mansoni	inositol monophosphatase	0.0044	0.0037	0.0011
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0169	0.0664	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0664	0.0654
Schistosoma mansoni	fad oxidoreductase	0.0169	0.0664	0.064
Schistosoma mansoni	hypothetical protein	0.0121	0.0421	0.0396
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0056	0.0096	0.0454
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0029	0.0278
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0077	0.0754
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0169	0.0664	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0664	0.0654
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0078	0.0205	0.0179
Brugia malayi	latrophilin 2 splice variant baaae	0.0121	0.0421	0.3861
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0077	0.0066
Schistosoma mansoni	lipoxygenase	0.0097	0.0304	0.0279
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0169	0.0664	1
Onchocerca volvulus		0.0052	0.0077	0.0402
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0169	0.0664	0.0652
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0037	0.0123
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0169	0.0664	1
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0169	0.0664	0.6232
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0029	0.0003
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0056	0.0096	0.0454
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0169	0.0664	0.064
Schistosoma mansoni	hypothetical protein	0.0056	0.0096	0.007
Loa Loa (eye worm)	carboxylesterase	0.0078	0.0205	0.0194
Trypanosoma cruzi	cytochrome P450, putative	0.0057	0.0099	0.1111
Trichomonas vaginalis	set domain proteins, putative	0.028	0.122	1
Schistosoma mansoni	hypothetical protein	0.0056	0.0096	0.007
Trypanosoma brucei	cytochrome P450, putative	0.0057	0.0099	0.1111
Echinococcus multilocularis	inositol monophosphatase 1	0.0044	0.0037	0.0068
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0052	0.0077	0.0066
Brugia malayi	MH2 domain containing protein	0.0144	0.0539	0.5005
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0139	0.0515	0.3183
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0052	0.0077	0.0066
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0077	0.0084
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0169	0.0664	1
Brugia malayi	Carboxylesterase family protein	0.0078	0.0205	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0205	0.0194
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0169	0.0664	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0702	0.0692
Echinococcus multilocularis	tumor protein p63	0.0348	0.1562	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0056	0.0096	0.0454
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0077	0.0754
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0029	0.0015
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0139	0.0515	0.3183
Brugia malayi	beta-lactamase family protein	0.0043	0.0029	0.0026
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0169	0.0664	0.0654
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0169	0.0664	1
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0169	0.0664	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0052	0.0077	0.0084
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.0077	0.0793
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0029	0.0032
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.0037	0.0066
Mycobacterium ulcerans	hypothetical protein	0.0052	0.0077	0.0066
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0169	0.0664	0.5332
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0029	0.0018
Loa Loa (eye worm)	CYP4Cod1	0.0057	0.0099	0.0089
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0029	0.0032
Echinococcus multilocularis	GPCR, family 2	0.0056	0.0096	0.0454
Brugia malayi	Inositol-1	0.0044	0.0037	0.0103
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0169	0.0664	1
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0169	0.0664	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0078	0.0205	0.0194
Brugia malayi	Latrophilin receptor protein 2	0.0056	0.0096	0.0681
Trichomonas vaginalis	inositol monophosphatase, putative	0.0044	0.0037	0.0066
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0169	0.0664	0.064
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0029	0.0003
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0169	0.0664	0.0654
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0052	0.0077	0.0066
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0029	0.0018
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0099	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0029	0.0018
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0169	0.0664	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0664	0.0654
Leishmania major	hypothetical protein, conserved	0.0169	0.0664	1
Brugia malayi	Pre-SET motif family protein	0.0246	0.105	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0177	0.0702	0.6602
Echinococcus granulosus	inositol monophosphatase 1	0.0044	0.0037	0.0068
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0169	0.0664	0.5332
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0057	0.0099	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0029	0.0018
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.0077	0.0793
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0077	0.0494
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.0077	0.0066
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0177	0.0702	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0029	0.0018
Brugia malayi	beta-lactamase	0.0043	0.0029	0.0026
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0169	0.0664	0.4156
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0029	0.0032
Echinococcus granulosus	tumor protein p63	0.0348	0.1562	1
Onchocerca volvulus		0.0051	0.0071	0.0353
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0029	0.0032
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0169	0.0664	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0044	0.0037	0.0026
Onchocerca volvulus		0.028	0.122	1
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0169	0.0664	0.0654
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0029	0.0032
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0169	0.0664	0.0654
Leishmania major	cytochrome p450-like protein	0.0057	0.0099	0.1111
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.0077	0.0754
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.0077	0.0494
Loa Loa (eye worm)	inositol-1	0.0044	0.0037	0.0026
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0246	0.105	0.104
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0421	0.0411
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0039	0.0011	0.0012
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0169	0.0664	0.4156
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0052	0.0077	0.0063
Loa Loa (eye worm)	cytochrome P450 family protein	0.0101	0.0324	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0205	0.0194
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0169	0.0664	0.6232
Schistosoma mansoni	hypothetical protein	0.0056	0.0096	0.007
Brugia malayi	RE18450p	0.0169	0.0664	0.6232
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0169	0.0664	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0177	0.0702	0.6602
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0044	0.0037	0.0123
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0052	0.0077	0.0063
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0029	0.0032
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0539	0.0528
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0037	0.0123
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0029	0.0018
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0056	0.0096	0.0681
Onchocerca volvulus	Putative fad oxidoreductase	0.0169	0.0664	0.5332
Brugia malayi	beta-lactamase family protein	0.0043	0.0029	0.0026
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0056	0.0096	0.0454
Echinococcus multilocularis	acetylcholinesterase	0.0078	0.0205	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0096	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0071	0.006
Echinococcus multilocularis	carboxylesterase 5A	0.0078	0.0205	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0077	0.0066
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0169	0.0664	1
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0169	0.0664	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.004	0.0013	0.0015
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0272	0.118	0.1289
Schistosoma mansoni	NAD dehydrogenase	0.0169	0.0664	0.064
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0071	0.0045
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0029	0.0018
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0029	0.0018
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0099	0.0089
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0169	0.0664	1
Mycobacterium ulcerans	lipase LipD	0.0043	0.0029	0.0018
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0029	0.0032
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0037	0.0123
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0169	0.0664	1
Brugia malayi	Carboxylesterase family protein	0.0078	0.0205	0.1744
Echinococcus granulosus	GPCR family 2	0.0056	0.0096	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0029	0.0018
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0029	0.0032
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0169	0.0664	0.4156
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0099	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0029	0.0018
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0029	0.0015
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0029	0.0018
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0169	0.0664	0.0652
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0037	0.0123
Brugia malayi	Cytochrome P450 family protein	0.0101	0.0324	0.2913
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0029	0.0026
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0539	0.0528
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0169	0.0664	0.4156
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0077	0.0066
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0029	0.0032
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0029	0.0018
Echinococcus granulosus	acetylcholinesterase	0.0078	0.0205	0.1163
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0169	0.0664	0.0654
Schistosoma mansoni	hypothetical protein	0.0056	0.0096	0.007
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0169	0.0664	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0057	0.0099	0.1111
Entamoeba histolytica	acyl-coA synthetase, putative	0.0052	0.0077	0.0793

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)		Inhibition of COX2 (unknown origin) by EIA	ChEMBL.	24508141
Inhibition (binding)		Inhibition of PLA2 (unknown origin) by Ellman's method	ChEMBL.	24508141
Inhibition (binding)		Inhibition of COX1 (unknown origin) by EIA	ChEMBL.	24508141
Inhibition (binding)	= 35 %	Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate at 0.01 uM after 5 mins by EIA	ChEMBL.	24508141
Inhibition (binding)	= 41.1 %	Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate at 0.1 uM after 5 mins by EIA	ChEMBL.	24508141
Inhibition (binding)	= 43.4 %	Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate at 1 uM after 5 mins by EIA	ChEMBL.	24508141
Inhibition (binding)	= 49.8 %	Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate at 10 uM after 5 mins by EIA	ChEMBL.	24508141
Inhibition (binding)	= 65 %	Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate at 100 uM after 5 mins by EIA	ChEMBL.	24508141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3113608

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1836338