Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peptidase family M28 containing protein | 0.0388 | 0.5344 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0388 | 0.5344 | 0.5344 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0388 | 0.5344 | 0.5344 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0.0596 | 0.1115 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Leishmania major | hypothetical protein, conserved | 0.0062 | 0.0596 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0.0596 | 0.1115 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0062 | 0.0596 | 0.1115 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0062 | 0.0596 | 0.0596 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0062 | 0.0596 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0388 | 0.5344 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0062 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.5344 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0062 | 0.0596 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0062 | 0.0596 | 0.0596 |
Schistosoma mansoni | tyrosine kinase | 0.0692 | 0.9764 | 0.9764 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0062 | 0.0596 | 0.0596 |
Schistosoma mansoni | nicalin (M28 family) | 0.0062 | 0.0596 | 0.0596 |
Mycobacterium ulcerans | hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0062 | 0.0596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Leishmania major | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0062 | 0.0596 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0.0596 | 0.1115 |
Brugia malayi | FXNA | 0.0062 | 0.0596 | 0.1115 |
Onchocerca volvulus | 0.0062 | 0.0596 | 0.1115 | |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0388 | 0.5344 | 0.5344 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0062 | 0.0596 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0062 | 0.0596 | 0.1115 |
Brugia malayi | nicalin | 0.0062 | 0.0596 | 0.1115 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.