Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Brugia malayi | Peptidase family M28 containing protein | 0.0388 | 0.5344 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0388 | 0.5344 | 0.5344 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0388 | 0.5344 | 0.5344 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0062 | 0.0596 | 0.1115 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0.0596 | 0.1115 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0.0596 | 0.1115 |
Leishmania major | hypothetical protein, conserved | 0.0062 | 0.0596 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0388 | 0.5344 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0062 | 0.0596 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0062 | 0.0596 | 0.0596 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0692 | 0.9764 | 0.9764 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0062 | 0.0596 | 0.0596 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0062 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.5344 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0062 | 0.0596 | 0.0596 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0062 | 0.0596 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0062 | 0.0596 | 0.0596 |
Schistosoma mansoni | nicalin (M28 family) | 0.0062 | 0.0596 | 0.0596 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Leishmania major | glutaminyl cyclase, putative | 0.0062 | 0.0596 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0062 | 0.0596 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0062 | 0.0596 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0596 | 0.1115 | |
Brugia malayi | FXNA | 0.0062 | 0.0596 | 0.1115 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0062 | 0.0596 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0388 | 0.5344 | 0.5344 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0.0596 | 0.1115 |
Mycobacterium tuberculosis | Conserved protein | 0.0062 | 0.0596 | 0.5 |
Brugia malayi | nicalin | 0.0062 | 0.0596 | 0.1115 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 0.1115 |
Brugia malayi | leucyl aminopeptidase | 0.0062 | 0.0596 | 0.1115 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.