TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 475 | Formula: C24H27ClN2O4S
H donors: 1 H acceptors: 3 LogP: 5.51 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(OC(=O)C1=C(C)NC(=C(C1c1csc(n1)c1ccc(cc1)Cl)C(=O)OC(C)C)C)C
InChi: 1S/C24H27ClN2O4S/c1-12(2)30-23(28)19-14(5)26-15(6)20(24(29)31-13(3)4)21(19)18-11-32-22(27-18)16-7-9-17(25)10-8-16/h7-13,21,26H,1-6H3
InChiKey: ZITJCQKDINNFFM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0213	0.0266	0.0414
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0194	0.0218	0.0218
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0106	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	epidermal growth factor receptor	0.0194	0.0218	0.0218
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0839	0.1815	0.1815
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.2057	0.4827	0.4827
Entamoeba histolytica	cysteine surface protein, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	tyrosin kinase, putative	0.0194	0.0218	0.0339
Echinococcus multilocularis	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Schistosoma mansoni	alpha-glucosidase	0.0135	0.0073	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.02	0.0234	0.0364
Onchocerca volvulus	Tankyrase homolog	0.02	0.0234	0.383
Schistosoma mansoni	ephrin receptor	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/RYK protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase Srms	0.0194	0.0218	0.0218
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0194	0.0218	0.0218
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	kinase suppressor of Ras 1	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	receptor protein kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	poly (ADP ribose) polymerase	0.042	0.0777	0.0777
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0194	0.0218	0.0218
Brugia malayi	MAP kinase sur-1	0.2141	0.5035	0.5035
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Brugia malayi	ephrin receptor 1 precursor	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0194	0.0218	0.0218
Trichomonas vaginalis	CMGC family protein kinase	0.2141	0.5035	1
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0194	0.0218	0.0218
Trichomonas vaginalis	CMGC family protein kinase	0.2141	0.5035	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0194	0.0218	0.0218
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein, conserved	0.0194	0.0218	0.0339
Brugia malayi	Raf kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.4149	1	1
Loa Loa (eye worm)	hypothetical protein	0.0353	0.0611	0.0611
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Brugia malayi	hypothetical protein	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Schistosoma mansoni	protein kinase	0.0213	0.0266	0.0266
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0157	0.0128	0.0128
Loa Loa (eye worm)	TK/Met protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	epidermal growth factor receptor	0.0194	0.0218	0.0218
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	protein kinase atn1, putative	0.0194	0.0218	0.0433
Loa Loa (eye worm)	hypothetical protein	0.1485	0.3411	0.3411
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	serine/threonine kinase, putative	0.0194	0.0218	0.0339
Loa Loa (eye worm)	TK/ACK protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.1485	0.3411	0.6775
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase HCK	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.02	0.0234	0.0364
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	zinc finger protein, putative	0.02	0.0234	0.0364
Echinococcus multilocularis	mitogen activated protein kinase	0.2141	0.5035	0.5035
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.2703	0.6423	0.6423
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/ALK protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0213	0.0266	0.0398
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.1284	0.2915	0.2915
Schistosoma mansoni	protein kinase	0.0213	0.0266	0.0266
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Trichomonas vaginalis	CAMK family protein kinase	0.0194	0.0218	0.0433
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0194	0.0218	0.3567
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0194	0.0218	0.0218
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2141	0.5035	1
Entamoeba histolytica	ankyrin repeat protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	poly ADP ribose polymerase 1	0.2703	0.6423	0.6423
Entamoeba histolytica	serine/threonine kinase, putative	0.0194	0.0218	0.0339
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Echinococcus granulosus	receptor type guanylyl cyclase	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Trichomonas vaginalis	AGC family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Trypanosoma brucei	protein kinase, putative	0.2141	0.5035	1
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.042	0.0777	0.1209
Plasmodium vivax	protein kinase, putative	0.0194	0.0218	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0157	0.0128	0.0128
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0194	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.4149	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0194	0.0218	0.0326
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	hypothetical protein	0.02	0.0234	0.0364
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trypanosoma cruzi	DNA repair protein, putative	0.0353	0.0611	0.1214
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0213	0.0266	0.0266
Echinococcus granulosus	tyrosine protein kinase pr2	0.0194	0.0218	0.0218
Entamoeba histolytica	receptor protein kinase, putative	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2141	0.5035	1
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Brugia malayi	Tyrosine-protein kinase abl-1	0.0194	0.0218	0.0218
Echinococcus multilocularis	FL cytokine receptor	0.0194	0.0218	0.0218
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.2808	0.6685	1
Trypanosoma cruzi	protein kinase, putative	0.0194	0.0218	0.0433
Entamoeba histolytica	hypothetical protein	0.02	0.0234	0.0364
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	alpha-glucosidase	0.0135	0.0073	0.0073
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0194	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Echinococcus granulosus	activated cdc42 kinase 1	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus multilocularis	c src tyrosine kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Echinococcus multilocularis	activated cdc42 kinase 1	0.0194	0.0218	0.0218
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/CSK protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	natriuretic peptide receptor 1	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0194	0.0218	0.0433
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Tnks protein	0.02	0.0234	0.0234
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0194	0.0218	0.3567
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	WGR domain containing protein	0.0839	0.1815	0.1815
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2141	0.5035	1
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Echinococcus multilocularis	tankyrase	0.02	0.0234	0.0234
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0194	0.0218	0.0218
Toxoplasma gondii	protein kinase domain-containing protein	0.0194	0.0218	0.0326
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2141	0.5035	1
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	ephrin receptor	0.0194	0.0218	0.0218
Echinococcus multilocularis	protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0194	0.0218	0.0218
Echinococcus granulosus	activated cdc42 kinase 1	0.0194	0.0218	0.0218
Trypanosoma brucei	Pseudokinase, putative	0.0194	0.0218	0.0433
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase shark	0.0194	0.0218	0.0218
Echinococcus granulosus	mitogen activated protein kinase	0.2141	0.5035	0.5035
Echinococcus multilocularis	tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Trypanosoma brucei	DNA repair protein, putative	0.0353	0.0611	0.1214
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	lysosomal alpha glucosidase	0.0157	0.0128	0.0128
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2141	0.5035	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0213	0.0266	0.0528
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Treponema pallidum	DNA ligase (lig)	0.0106	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	CMGC family protein kinase	0.2141	0.5035	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0194	0.0218	0.0218
Trypanosoma cruzi	protein kinase, putative	0.0194	0.0218	0.0433
Entamoeba histolytica	tyrosin kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	epidermal growth factor receptor	0.0194	0.0218	0.0218
Echinococcus granulosus	c src tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2141	0.5035	0.5035
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0213	0.0266	0.0528
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Echinococcus granulosus	mitogen activated protein kinase 3	0.2141	0.5035	0.5035
Trichomonas vaginalis	TK family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0213	0.0266	0.0266
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	STE family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	serine/threonine kinase, putative	0.0194	0.0218	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0213	0.0266	0.0266
Chlamydia trachomatis	DNA ligase	0.0106	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0194	0.0218	0.0433
Brugia malayi	WGR domain containing protein	0.1485	0.3411	0.3411
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.2703	0.6423	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosin kinase, putative	0.0194	0.0218	0.0339
Brugia malayi	Furin-like cysteine rich region family protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.4149	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Tyrosine-protein kinase PR2	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus multilocularis	tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/EPH protein kinase	0.0194	0.0218	0.0218
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0194	0.0218	0.0218
Schistosoma mansoni	serine/threonine protein kinase	0.2141	0.5035	0.5035
Echinococcus granulosus	activin receptor type	0.0213	0.0266	0.0266
Echinococcus granulosus	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trypanosoma brucei	protein kinase, putative	0.0213	0.0266	0.0528
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.4149	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.1485	0.3411	0.3411
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0157	0.0128	0.0128
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0194	0.0218	0.0218
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.1485	0.3411	0.3411
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Echinococcus granulosus	poly (ADP ribose) polymerase	0.042	0.0777	0.0777
Onchocerca volvulus		0.0194	0.0218	0.3567
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	protein tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FAK protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase	0.0194	0.0218	0.0218
Brugia malayi	Guanylyl cyclase protein 23	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Schistosoma mansoni	protein kinase	0.0213	0.0266	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Plasmodium falciparum	tyrosine kinase-like protein	0.0194	0.0218	0.8198
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0157	0.0128	0.0128
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Onchocerca volvulus	DNA ligase 3 homolog	0.0353	0.0611	1
Trypanosoma brucei	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0353	0.0611	0.1214
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	geminin	0.0164	0.0143	0.0143
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.0164	0.0143	0.0143
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Brugia malayi	protein-tyrosine kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	transfer RNA-Thr	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Loa Loa (eye worm)	SRC-1	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0194	0.0218	0.0218
Brugia malayi	WGR domain containing protein	0.2703	0.6423	0.6423
Echinococcus multilocularis	geminin	0.0164	0.0143	0.0143
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Plasmodium falciparum	protein kinase, putative	0.0213	0.0266	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0194	0.0218	0.0339
Loa Loa (eye worm)	TK/DDR protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2141	0.5035	0.7532
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	insulin receptor	0.0194	0.0218	0.0218
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	ankyrin repeat protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Echinococcus multilocularis	integrin linked protein kinase	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0194	0.0218	1
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Giardia lamblia	Kinase, CMGC MAPK	0.2141	0.5035	1
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0213	0.0266	0.0528
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Brugia malayi	SH2 domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	tankyrase	0.02	0.0234	0.0234
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.1065	0.2373	0.2373
Echinococcus multilocularis	tyrosine protein kinase shark	0.0194	0.0218	0.0218
Brugia malayi	Receptor family ligand binding region containing protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0194	0.0218	0.0218
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0194	0.0218	0.0433
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0194	0.0218	0.0339
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	serine/threonine kinase, putative	0.0194	0.0218	0.0339
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Entamoeba histolytica	serine/threonine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Onchocerca volvulus		0.0194	0.0218	0.3567
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Echinococcus multilocularis	insulin receptor	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0194	0.0218	0.0218
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0106	0	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0194	0.0218	0.0218
Echinococcus granulosus	poly (ADP ribose) polymerase	0.042	0.0777	0.0777
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Loa Loa (eye worm)	TK/INSR protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	hypothetical protein	0.0164	0.0143	0.0143
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2141	0.5035	0.5035
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/ROR protein kinase	0.0194	0.0218	0.0218
Plasmodium falciparum	protein kinase, putative	0.0194	0.0218	0.8198
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0106	0	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	serine/threonine RGC	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Echinococcus granulosus	ephrin type A receptor 4 A	0.0194	0.0218	0.0218
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	epidermal growth factor receptor	0.0194	0.0218	0.0218
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Onchocerca volvulus	Tyrosine kinase homolog	0.0194	0.0218	0.3567
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0194	0.0218	0.0433
Echinococcus granulosus	tyrosine protein kinase Blk	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Echinococcus granulosus	protein tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Brugia malayi	C-terminal src kinase protein 1	0.0194	0.0218	0.0218
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2141	0.5035	1
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Toxoplasma gondii	STE kinase	0.0194	0.0218	0.0326
Entamoeba histolytica	hypothetical protein	0.0194	0.0218	0.0339
Onchocerca volvulus		0.0194	0.0218	0.3567
Plasmodium falciparum	tyrosine kinase-like protein	0.0194	0.0218	0.8198
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0194	0.0218	0.0218
Giardia lamblia	Protein 21.1	0.0194	0.0218	0.0433
Brugia malayi	integrin-linked kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	serine/threonine kinase, putative	0.0194	0.0218	0.0339
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0194	0.0218	0.0218
Schistosoma mansoni	protein tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	integrin linked protein kinase	0.0194	0.0218	0.0218
Onchocerca volvulus		0.0194	0.0218	0.3567
Leishmania major	DNA repair protein, putative	0.0353	0.0611	0.0816
Echinococcus multilocularis	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Toxoplasma gondii	protein kinase	0.0194	0.0218	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.0234	0.0465
Entamoeba histolytica	tyrosin kinase, putative	0.0194	0.0218	0.0339
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0194	0.0218	0.0218
Echinococcus granulosus	poly adp ribose polymerase 2	0.1485	0.3411	0.3411
Schistosoma mansoni	tankyrase	0.02	0.0234	0.0234
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0194	0.0218	0.0218
Trypanosoma brucei	poly(adp-ribose) polymerase	0.1485	0.3411	0.6775
Trypanosoma cruzi	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0353	0.0611	0.1214
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Brugia malayi	hypothetical protein	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	activin receptor type	0.0213	0.0266	0.0266
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0194	0.0218	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Giardia lamblia	Kinase, NEK	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.062	0.1272	0.1272
Brugia malayi	SH2 domain containing protein	0.0194	0.0218	0.0218
Leishmania major	hypothetical protein, conserved	0.0353	0.0611	0.0816
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0194	0.0218	0.0218
Leishmania major	protein kinase, putative	0.0213	0.0266	0.0099
Brugia malayi	SRC-1	0.0194	0.0218	0.0218
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0194	0.0218	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0194	0.0218	0.0218
Giardia lamblia	Kinase, NEK	0.0194	0.0218	0.0433
Onchocerca volvulus		0.0194	0.0218	0.3567
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2141	0.5035	1
Onchocerca volvulus		0.0194	0.0218	0.3567
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Giardia lamblia	Kinase	0.0194	0.0218	0.0433
Loa Loa (eye worm)	tnks protein	0.02	0.0234	0.0234
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.1485	0.3411	0.6775
Loa Loa (eye worm)	TK/ABL protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0194	0.0218	0.0218
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0194	0.0218	0.0339
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0194	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.0218	0.0433
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0194	0.0218	0.0218
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0194	0.0218	0.0326
Onchocerca volvulus		0.0194	0.0218	0.3567
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Trichomonas vaginalis	CMGC family protein kinase	0.2141	0.5035	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Echinococcus multilocularis	heat shock protein 70	0.0194	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase csk	0.0194	0.0218	0.0218
Plasmodium falciparum	protein kinase, putative	0.0194	0.0218	0.8198
Entamoeba histolytica	tyrosine kinase, putative	0.0194	0.0218	0.0339
Schistosoma mansoni	protein kinase	0.0194	0.0218	0.0218
Entamoeba histolytica	protein kinase, putative	0.0194	0.0218	0.0339
Loa Loa (eye worm)	TK protein kinase	0.0194	0.0218	0.0218
Schistosoma mansoni	tyrosine kinase	0.0194	0.0218	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0194	0.0218	0.0433
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0194	0.0218	0.0339
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.2703	0.6423	0.6423
Brugia malayi	hypothetical protein	0.0194	0.0218	0.0218

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.72 10'-5M	Antagonist activity at Calcium channel in Cavia porcellus (guinea pig) ileal smooth muscle assessed as inhibition of 40 mM KCl-induced contraction compound pretreated for 15 min before KCl treatment	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2262231

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1839902