Detailed information for compound 1839933

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.92 | Formula: C21H21ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1csc(n1)c1ccc(cc1)Cl)C(=O)OC)C
  • InChi: 1S/C21H21ClN2O4S/c1-5-28-21(26)17-12(3)23-11(2)16(20(25)27-4)18(17)15-10-29-19(24-15)13-6-8-14(22)9-7-13/h6-10,18,23H,5H2,1-4H3
  • InChiKey: DJCJNWKEZCIACY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica receptor protein kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus poly (ADP ribose) polymerase 0.042 0.0777 0.0777
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0194 0.0218 0.0218
Brugia malayi ephrin receptor 1 precursor 0.0194 0.0218 0.0218
Brugia malayi MAP kinase sur-1 0.2141 0.5035 0.5035
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase HCK 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Brugia malayi Raf kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein, conserved 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0353 0.0611 0.0611
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.4149 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0128 0.0128
Schistosoma mansoni protein kinase 0.0213 0.0266 0.0266
Brugia malayi hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/Met protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0213 0.0266 0.0414
Schistosoma mansoni tyrosine protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0106 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.2057 0.4827 0.4827
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0218 0.0218
Echinococcus granulosus poly (ADP ribose) polymerase 0.0839 0.1815 0.1815
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Schistosoma mansoni alpha-glucosidase 0.0135 0.0073 0.0073
Entamoeba histolytica cysteine surface protein, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus Tankyrase homolog 0.02 0.0234 0.383
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Loa Loa (eye worm) TK/RYK protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni ephrin receptor 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Srms 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus kinase suppressor of Ras 1 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0194 0.0218 0.0218
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.2141 0.5035 1
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica ankyrin repeat protein 0.0194 0.0218 0.0339
Echinococcus granulosus poly ADP ribose polymerase 1 0.2703 0.6423 0.6423
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis protein KINase family member (kin 25) 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0194 0.0218 0.0433
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Echinococcus granulosus receptor type guanylyl cyclase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Trichomonas vaginalis AGC family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase csk 0.0194 0.0218 0.0218
Trypanosoma brucei protein kinase, putative 0.2141 0.5035 1
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Plasmodium vivax protein kinase, putative 0.0194 0.0218 1
Entamoeba histolytica hypothetical protein 0.042 0.0777 0.1209
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0194 0.0218 0.0218
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0128 0.0128
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.4149 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0194 0.0218 0.0326
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) hypothetical protein 0.1485 0.3411 0.3411
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis protein kinase atn1, putative 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0194 0.0218 0.0218
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0194 0.0218 0.0218
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.1485 0.3411 0.6775
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/ACK protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Echinococcus granulosus tyrosine protein kinase HCK 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Entamoeba histolytica zinc finger protein, putative 0.02 0.0234 0.0364
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.2703 0.6423 0.6423
Echinococcus multilocularis mitogen activated protein kinase 0.2141 0.5035 0.5035
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/ALK protein kinase 0.0194 0.0218 0.0218
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0213 0.0266 0.0398
Echinococcus multilocularis kinase suppressor of Ras 1 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1284 0.2915 0.2915
Schistosoma mansoni protein kinase 0.0213 0.0266 0.0266
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0194 0.0218 0.3567
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0194 0.0218 0.0218
Schistosoma mansoni alpha-glucosidase 0.0135 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Echinococcus granulosus activated cdc42 kinase 1 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Echinococcus multilocularis c src tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis activated cdc42 kinase 1 0.0194 0.0218 0.0218
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/CSK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Tnks protein 0.02 0.0234 0.0234
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0194 0.0218 0.0433
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0194 0.0218 0.3567
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Echinococcus granulosus WGR domain containing protein 0.0839 0.1815 0.1815
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.2141 0.5035 1
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tankyrase 0.02 0.0234 0.0234
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0194 0.0218 0.0218
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.2141 0.5035 1
Toxoplasma gondii protein kinase domain-containing protein 0.0194 0.0218 0.0326
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Loa Loa (eye worm) protein kinase domain-containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma cruzi DNA repair protein, putative 0.0353 0.0611 0.1214
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0213 0.0266 0.0266
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica receptor protein kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase pr2 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.2141 0.5035 1
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Tyrosine-protein kinase abl-1 0.0194 0.0218 0.0218
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.2808 0.6685 1
Entamoeba histolytica hypothetical protein 0.02 0.0234 0.0364
Trypanosoma cruzi protein kinase, putative 0.0194 0.0218 0.0433
Echinococcus multilocularis FL cytokine receptor 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trypanosoma cruzi protein kinase, putative 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) serine/threonine protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus c src tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0213 0.0266 0.0528
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis mitogen activated protein kinase 3 0.2141 0.5035 0.5035
Echinococcus granulosus tyrosine protein kinase Src64B 0.0194 0.0218 0.0218
Echinococcus granulosus mitogen activated protein kinase 3 0.2141 0.5035 0.5035
Trichomonas vaginalis TK family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni hypothetical protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Lyn 0.0213 0.0266 0.0266
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis STE family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0213 0.0266 0.0266
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0194 0.0218 0.0218
Chlamydia trachomatis DNA ligase 0.0106 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0194 0.0218 0.0433
Brugia malayi WGR domain containing protein 0.1485 0.3411 0.3411
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Immunoglobulin I-set domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.2703 0.6423 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Brugia malayi Furin-like cysteine rich region family protein 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.4149 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni ephrin receptor 0.0194 0.0218 0.0218
Echinococcus multilocularis protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus activated cdc42 kinase 1 0.0194 0.0218 0.0218
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trypanosoma brucei Pseudokinase, putative 0.0194 0.0218 0.0433
Echinococcus granulosus tyrosine protein kinase ABL1 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus mitogen activated protein kinase 0.2141 0.5035 0.5035
Echinococcus granulosus tyrosine protein kinase shark 0.0194 0.0218 0.0218
Trypanosoma brucei DNA repair protein, putative 0.0353 0.0611 0.1214
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0128 0.0128
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0213 0.0266 0.0528
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.2141 0.5035 1
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Treponema pallidum DNA ligase (lig) 0.0106 0 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Echinococcus granulosus protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni protein kinase 0.0213 0.0266 0.0266
Plasmodium falciparum tyrosine kinase-like protein 0.0194 0.0218 0.8198
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0128 0.0128
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0353 0.0611 0.1214
Onchocerca volvulus DNA ligase 3 homolog 0.0353 0.0611 1
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus geminin 0.0164 0.0143 0.0143
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0164 0.0143 0.0143
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Echinococcus multilocularis transfer RNA-Thr 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Brugia malayi protein-tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0194 0.0218 0.0218
Brugia malayi WGR domain containing protein 0.2703 0.6423 0.6423
Loa Loa (eye worm) SRC-1 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis geminin 0.0164 0.0143 0.0143
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Plasmodium falciparum protein kinase, putative 0.0213 0.0266 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/DDR protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Brugia malayi Tyrosine-protein kinase PR2 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.2141 0.5035 0.5035
Loa Loa (eye worm) TK/EPH protein kinase 0.0194 0.0218 0.0218
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0194 0.0218 0.0218
Echinococcus granulosus activin receptor type 0.0213 0.0266 0.0266
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma brucei protein kinase, putative 0.0213 0.0266 0.0528
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0128 0.0128
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis raf serine:threonine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.4149 1 1
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.1485 0.3411 0.3411
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0194 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1485 0.3411 0.3411
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Echinococcus granulosus poly (ADP ribose) polymerase 0.042 0.0777 0.0777
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Loa Loa (eye worm) TK/FAK protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis protein tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Guanylyl cyclase protein 23 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus granulosus tyrosine protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.1065 0.2373 0.2373
Echinococcus granulosus tankyrase 0.02 0.0234 0.0234
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) hypothetical protein 0.0194 0.0218 0.0218
Brugia malayi Receptor family ligand binding region containing protein 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase shark 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0194 0.0218 0.0218
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0194 0.0218 0.0433
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0194 0.0218 0.0339
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Onchocerca volvulus 0.0194 0.0218 0.3567
Onchocerca volvulus 0.0194 0.0218 0.3567
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis insulin receptor 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0106 0 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0194 0.0218 0.0218
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus raf serine:threonine protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus poly (ADP ribose) polymerase 0.042 0.0777 0.0777
Echinococcus granulosus tyrosine protein kinase csk 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.2141 0.5035 0.7532
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus insulin receptor 0.0194 0.0218 0.0218
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica ankyrin repeat protein 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Onchocerca volvulus 0.0194 0.0218 0.3567
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Echinococcus multilocularis integrin linked protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Giardia lamblia Kinase, CMGC MAPK 0.2141 0.5035 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0194 0.0218 1
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0213 0.0266 0.0528
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Brugia malayi SH2 domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus multilocularis receptor type guanylyl cyclase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Onchocerca volvulus 0.0194 0.0218 0.3567
Plasmodium falciparum tyrosine kinase-like protein 0.0194 0.0218 0.8198
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0194 0.0218 0.0218
Giardia lamblia Protein 21.1 0.0194 0.0218 0.0433
Toxoplasma gondii STE kinase 0.0194 0.0218 0.0326
Entamoeba histolytica hypothetical protein 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica serine/threonine kinase, putative 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi integrin-linked kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni protein tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Onchocerca volvulus 0.0194 0.0218 0.3567
Echinococcus granulosus integrin linked protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Brugia malayi bone morphogenetic protein type 1 receptor 0.0194 0.0218 0.0218
Leishmania major DNA repair protein, putative 0.0353 0.0611 0.0816
Echinococcus granulosus fibroblast growth factor receptor 4 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0234 0.0465
Toxoplasma gondii protein kinase 0.0194 0.0218 0.0326
Loa Loa (eye worm) TK/EGFR protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosin kinase, putative 0.0194 0.0218 0.0339
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Echinococcus granulosus poly adp ribose polymerase 2 0.1485 0.3411 0.3411
Echinococcus granulosus tyrosine protein kinase Src42A 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus multilocularis tyrosine protein kinase Srms 0.0194 0.0218 0.0218
Schistosoma mansoni tankyrase 0.02 0.0234 0.0234
Brugia malayi hypothetical protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0353 0.0611 0.1214
Trypanosoma brucei poly(adp-ribose) polymerase 0.1485 0.3411 0.6775
Schistosoma mansoni hypothetical protein 0.0164 0.0143 0.0143
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/INSR protein kinase 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.2141 0.5035 0.5035
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Plasmodium falciparum protein kinase, putative 0.0194 0.0218 0.8198
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/ROR protein kinase 0.0194 0.0218 0.0218
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0106 0 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus ephrin type A receptor 4 A 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase csk 0.0194 0.0218 0.0218
Schistosoma mansoni serine/threonine RGC 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0218 0.0218
Brugia malayi Immunoglobulin I-set domain containing protein 0.0194 0.0218 0.0218
Onchocerca volvulus Tyrosine kinase homolog 0.0194 0.0218 0.3567
Trichomonas vaginalis protein tyrosine kinase, putative 0.0194 0.0218 0.0433
Echinococcus granulosus protein tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus granulosus retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Loa Loa (eye worm) RGC/RGC protein kinase 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Echinococcus granulosus tyrosine protein kinase Blk 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Brugia malayi C-terminal src kinase protein 1 0.0194 0.0218 0.0218
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.2141 0.5035 1
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.1485 0.3411 0.6775
Loa Loa (eye worm) TK/ABL protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Echinococcus granulosus tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis ephrin type A receptor 4 A 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0194 0.0218 0.0218
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase pr2 0.0194 0.0218 0.0218
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0194 0.0218 0.0326
Echinococcus granulosus tyrosine protein kinase Fyn 0.0194 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0218 0.0433
Onchocerca volvulus 0.0194 0.0218 0.3567
Trichomonas vaginalis CMGC family protein kinase 0.2141 0.5035 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0194 0.0218 0.0218
Echinococcus granulosus tyrosine protein kinase csk 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis heat shock protein 70 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Entamoeba histolytica tyrosine kinase, putative 0.0194 0.0218 0.0339
Plasmodium falciparum protein kinase, putative 0.0194 0.0218 0.8198
Schistosoma mansoni protein kinase 0.0194 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Brugia malayi hypothetical protein 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK protein kinase 0.0194 0.0218 0.0218
Schistosoma mansoni poly [ADP-ribose] polymerase 0.2703 0.6423 0.6423
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0194 0.0218 0.0339
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0218 0.0339
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Echinococcus multilocularis activin receptor type 0.0213 0.0266 0.0266
Plasmodium vivax tyrosine kinase-like protein, putative 0.0194 0.0218 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis tyrosine protein kinase Blk 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Echinococcus multilocularis poly (ADP ribose) polymerase 0.062 0.1272 0.1272
Brugia malayi SH2 domain containing protein 0.0194 0.0218 0.0218
Giardia lamblia Kinase, NEK 0.0194 0.0218 0.0433
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Echinococcus multilocularis tyrosine protein kinase Abl 0.0194 0.0218 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0194 0.0218 0.0433
Leishmania major hypothetical protein, conserved 0.0353 0.0611 0.0816
Leishmania major protein kinase, putative 0.0213 0.0266 0.0099
Brugia malayi SRC-1 0.0194 0.0218 0.0218
Giardia lamblia Kinase, NEK 0.0194 0.0218 0.0433
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0194 0.0218 0.0218
Brugia malayi Protein kinase domain containing protein 0.0194 0.0218 0.0218
Loa Loa (eye worm) TK/FER protein kinase 0.0194 0.0218 0.0218
Onchocerca volvulus 0.0194 0.0218 0.3567
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.2141 0.5035 1
Onchocerca volvulus 0.0194 0.0218 0.3567
Entamoeba histolytica protein kinase, putative 0.0194 0.0218 0.0339
Giardia lamblia Kinase 0.0194 0.0218 0.0433
Loa Loa (eye worm) tnks protein 0.02 0.0234 0.0234

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.2 10'-5M Antagonist activity at Calcium channel in Cavia porcellus (guinea pig) ileal smooth muscle assessed as inhibition of 40 mM KCl-induced contraction compound pretreated for 15 min before KCl treatment ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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