Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0048 | 0.0354 | 0.4953 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4715 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0118 | 0.097 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.0076 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | hypothetical protein | 0.026 | 0.2779 | 0.9903 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.0076 | 0.0068 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0025 | 0.0088 | 0.048 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0119 | 0.1172 | 0.1121 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0077 | 0.0686 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.1172 | 0.6681 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0077 | 0.0686 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0076 | 0.0019 |
Echinococcus granulosus | ATPase H transporting lysosomal accessory | 0.0262 | 0.2806 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.0076 | 0.0434 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0413 | 0.2356 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.1172 | 0.6681 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.0076 | 0.0019 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0413 | 0.1294 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0097 | 0.0915 | 0.0862 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0048 | 0.0354 | 0.4953 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0039 | 0.025 | 0.3056 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0057 | 0.049 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0038 | 0.0246 | 0.0688 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0077 | 0.0686 | 0.2288 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0039 | 0.025 | 0.3056 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0.0118 | 0.3173 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0717 | 0.4088 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.0076 | 0.0068 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0118 | 0.2056 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 0.0686 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0118 | 0.3173 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0038 | 0.0246 | 0.2031 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.0076 | 0.0068 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0027 | 0.0118 | 0.1011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0076 | 0.0019 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0039 | 0.025 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0044 | 0.0316 | 0.026 |
Brugia malayi | ecdysteroid receptor | 0.0024 | 0.0076 | 0.0068 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0119 | 0.1172 | 0.1121 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0038 | 0.0246 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.1754 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0.0118 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0118 | 0.3226 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Brugia malayi | hypothetical protein | 0.0262 | 0.2806 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.0076 | 0.0434 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.026 | 0.2779 | 0.2738 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2806 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0413 | 0.2356 |
Echinococcus multilocularis | ATPase, H+ transporting, lysosomal accessory | 0.0262 | 0.2806 | 0.2764 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0039 | 0.025 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0097 | 0.0915 | 0.5216 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0077 | 0.0686 | 0.2288 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.0076 | 0.0434 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0079 | 0.0717 | 1 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0039 | 0.025 | 0.1424 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0038 | 0.0246 | 0.9833 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0076 | 0.0068 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0039 | 0.025 | 1 |
Onchocerca volvulus | 0.0053 | 0.0413 | 0.4019 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.026 | 0.2779 | 0.9903 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0077 | 0.0686 | 0.3914 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0119 | 0.1172 | 0.4054 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.0076 | 0.0068 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.1754 | 1 |
Onchocerca volvulus | 0.0097 | 0.0915 | 1 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.0076 | 0.0068 |
Echinococcus granulosus | dna polymerase kappa | 0.0048 | 0.0354 | 0.1079 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0039 | 0.025 | 0.0699 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.0076 | 0.0068 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0039 | 0.025 | 0.2131 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.0076 | 0.0019 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.1172 | 0.6681 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.0076 | 0.0068 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.0076 | 0.0068 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0027 | 0.0118 | 0.1011 |
Giardia lamblia | DINP protein human, muc B family | 0.0025 | 0.0088 | 0.157 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.0076 | 0.0434 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0038 | 0.0246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0097 | 0.0915 | 0.3119 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0048 | 0.0354 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.0076 | 0.0434 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0076 | 0.0434 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0038 | 0.0246 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 0.0686 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.0076 | 0.0434 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0.1484 | 0.5191 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0025 | 0.0088 | 0.1596 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.0076 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0039 | 0.025 | 0.2915 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0032 | 0.0169 | 0.2138 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0915 | 0.3119 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.0076 | 0.0068 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0039 | 0.025 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4953 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0039 | 0.025 | 0.0699 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.0118 | 0.1377 |
Leishmania major | ATPase alpha subunit | 0.0032 | 0.0169 | 0.1767 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.0076 | 0.0068 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0077 | 0.0686 | 0.2288 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.0076 | 0.0019 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0027 | 0.0118 | 0.3226 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.0076 | 0.0068 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.017 | 0.1754 | 0.1706 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.0076 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0221 | 0.0595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.0076 | 0.0068 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0057 | 0.0327 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0027 | 0.0118 | 0.2056 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4715 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.0076 | 0.0068 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.0076 | 0.0068 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0039 | 0.025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.0076 | 0.0068 |
Leishmania major | ATPase alpha subunit | 0.0032 | 0.0169 | 0.1767 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4715 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0039 | 0.025 | 0.3369 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0038 | 0.0246 | 0.019 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.1484 | 0.8464 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.0076 | 0.0068 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0039 | 0.025 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0057 | 0.0451 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0025 | 0.0088 | 0.0909 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0038 | 0.0246 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0146 | 0.1484 | 0.1435 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0038 | 0.0246 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0097 | 0.0915 | 0.3119 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0032 | 0.0169 | 0.2138 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0717 | 0.4088 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.0076 | 0.0434 |
Brugia malayi | Melibiase family protein | 0.0079 | 0.0717 | 0.24 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.0221 | 0.2934 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0027 | 0.0118 | 0.097 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0048 | 0.0354 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.0076 | 0.0068 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.1172 | 0.6681 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0266 | 0.3619 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0354 | 0.4715 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0039 | 0.025 | 0.3056 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | polk-prov protein | 0.0036 | 0.0221 | 0.0595 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.0076 | 0.0068 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.0076 | 0.0068 |
Leishmania major | DNA polymerase kappa, putative | 0.0025 | 0.0088 | 0.048 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0044 | 0.0316 | 0.0941 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0077 | 0.0686 | 0.0633 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.0076 | 0.0068 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.0076 | 0.0068 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0039 | 0.025 | 0.0193 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0038 | 0.0246 | 0.0688 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0076 | 0.0434 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.0076 | 0.0068 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0039 | 0.025 | 0.3056 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0038 | 0.0246 | 0.9833 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 0.0686 | 1 |
Brugia malayi | vacuolar ATP synthase subunit B | 0.0039 | 0.025 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma brucei | unspecified product | 0.004 | 0.0266 | 0.3619 |
Echinococcus multilocularis | dna polymerase kappa | 0.0048 | 0.0354 | 0.0298 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0048 | 0.0354 | 0.4497 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0057 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0076 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.0221 | 0.2934 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0717 | 0.24 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.0076 | 0.0019 |
Trichomonas vaginalis | ATP synthase, putative | 0.0039 | 0.025 | 0.2915 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.0076 | 0.0434 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0048 | 0.0354 | 0.4497 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.0076 | 0.0019 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0038 | 0.0246 | 0.1405 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.2779 | 0.9903 |
Toxoplasma gondii | melibiase subfamily protein | 0.0119 | 0.1172 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0038 | 0.0246 | 0.6373 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.