Detailed information for compound 18438

Basic information

Technical information
  • TDR Targets ID: 18438
  • Name: 1-[4-[3-[4-[bis(4-chlorophenyl)-hydroxymethyl ]piperidin-1-yl]propoxy]-3-methoxyphenyl]etha none
  • MW: 542.493 | Formula: C30H33Cl2NO4
  • H donors: 1 H acceptors: 2 LogP: 6.27 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OCCCN1CCC(CC1)C(c1ccc(cc1)Cl)(c1ccc(cc1)Cl)O)C(=O)C
  • InChi: 1S/C30H33Cl2NO4/c1-21(34)22-4-13-28(29(20-22)36-2)37-19-3-16-33-17-14-25(15-18-33)30(35,23-5-9-26(31)10-6-23)24-7-11-27(32)12-8-24/h4-13,20,25,35H,3,14-19H2,1-2H3
  • InChiKey: BTQCYONFXSTTLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-[3-[4-[bis(4-chlorophenyl)-hydroxy-methyl]-1-piperidyl]propoxy]-3-methoxy-phenyl]ethanone
  • 1-[4-[3-[4-[bis(4-chlorophenyl)-hydroxymethyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
  • 1-[4-[3-[4-[bis(4-chlorophenyl)-hydroxy-methyl]piperidin-1-yl]propoxy]-3-methoxy-phenyl]ethanone
  • 1-[4-[3-[4-[bis(4-chlorophenyl)-hydroxy-methyl]piperidino]propoxy]-3-methoxy-phenyl]ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit alpha 0.0039 0.0246 1
Echinococcus multilocularis dna polymerase kappa 0.0049 0.0354 0.0298
Brugia malayi ATP synthase alpha chain, mitochondrial precursor, putative 0.0039 0.0246 0.0466
Brugia malayi Melibiase family protein 0.0082 0.0717 0.1625
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0076 0.0046
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.0686 0.155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0354 0.4715
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0076 0.0434
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0076 0.0046
Giardia lamblia Vacuolar ATP synthase subunit B 0.004 0.025 1
Mycobacterium ulcerans F0F1 ATP synthase subunit alpha 0.0039 0.0246 0.6373
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0076 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0076 0.0046
Leishmania major ATPase alpha subunit 0.0032 0.0169 0.1767
Plasmodium vivax ATP synthase alpha chain, putative 0.0039 0.0246 0.5111
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.004 0.025 0.3056
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0686 1
Brugia malayi hypothetical protein 0.0267 0.2779 0.6706
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0118 0.2056
Brugia malayi polk-prov protein 0.0037 0.0221 0.0403
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0118 0.1011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0076 0.0046
Schistosoma mansoni hypothetical protein 0.0054 0.0413 0.2356
Mycobacterium tuberculosis Probable ATP synthase alpha chain AtpA 0.0039 0.0246 0.5111
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0056 0.0427 0.588
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0413 0.0876
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0427 0.6066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0076 0.0046
Schistosoma mansoni survival motor neuron protein 0.0054 0.0413 0.2356
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0076 0.0019
Brugia malayi Isocitrate dehydrogenase 0.0056 0.0427 0.0911
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0123 0.1172 0.6681
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0076 0.0019
Echinococcus multilocularis L aminoadipate semialdehyde 0.0099 0.0915 0.0862
Brugia malayi isocitrate dehydrogenase 0.0056 0.0427 0.0911
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0354 0.4715
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Echinococcus granulosus ATPase H transporting lysosomal accessory 0.0387 0.4116 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0056 0.0427 1
Toxoplasma gondii melibiase subfamily protein 0.0123 0.1172 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.0686 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0123 0.1172 0.1121
Schistosoma mansoni ap endonuclease 0.0022 0.0057 0.0327
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0118 0.1649
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0686 1
Onchocerca volvulus 0.0054 0.0413 0.4019
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0316 0.0637
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0123 0.1172 0.1121
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0427 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0032 0.0169 0.2138
Schistosoma mansoni thyroid hormone receptor 0.0175 0.1754 1
Onchocerca volvulus 0.0099 0.0915 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0118 0.1649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0076 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0076 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0123 0.1172 0.6681
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0099 0.0915 0.5216
Schistosoma mansoni coup transcription factor 0.0024 0.0076 0.0434
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0057 0.0451
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0427 0.3647
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0076 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0076 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0076 0.0046
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0076 0.0046
Treponema pallidum V-type ATP synthase subunit B 0.004 0.025 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0076 0.0434
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0076 0.0434
Echinococcus multilocularis ATP synthase subunit alpha, mitochondrial 0.0039 0.0246 0.019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0076 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0221 0.2934
Brugia malayi hypothetical protein 0.0387 0.4116 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0056 0.0427 0.6066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0076 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0076 0.0434
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.2779 0.6706
Loa Loa (eye worm) hypothetical protein 0.0387 0.4116 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0076 0.0046
Plasmodium falciparum ATP synthase F1, alpha subunit 0.0039 0.0246 0.5111
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.004 0.025 0.2131
Schistosoma mansoni thyroid hormone receptor 0.0175 0.1754 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0118 0.1011
Mycobacterium leprae PROBABLE ATP SYNTHASE BETA CHAIN ATPD 0.0039 0.0246 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0076 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0123 0.1172 0.6681
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.0354 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0056 0.0427 0.0372
Loa Loa (eye worm) hypothetical protein 0.0267 0.2779 0.6706
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.0686 0.0633
Plasmodium falciparum V-type proton ATPase subunit B 0.004 0.025 0.5197
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0427 0.588
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0076 0.0434
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0076 0.0019
Loa Loa (eye worm) hypothetical protein 0.0082 0.0717 0.1625
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0076 0.0046
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0427 0.588
Echinococcus multilocularis isocitrate dehydrogenase 0.0056 0.0427 0.0372
Echinococcus multilocularis ATPase, H+ transporting, lysosomal accessory 0.0387 0.4116 0.4082
Loa Loa (eye worm) hypothetical protein 0.0099 0.0915 0.2112
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0686 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0316 0.026
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0076 0.0434
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0076 0.0046
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.004 0.025 0.1424
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0118 0.097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0076 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0056 0.0427 0.2437
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0076 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0076 0.0046
Brugia malayi steroid hormone receptor 0.0024 0.0076 0.0046
Giardia lamblia DINP protein human, muc B family 0.0025 0.0088 0.157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.004 0.025 0.3056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0717 0.4088
Leishmania major vacuolar ATP synthase subunit b, putative 0.004 0.025 0.3056
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0221 0.2934
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0151 0.1484 0.3515
Trichomonas vaginalis ATP synthase, putative 0.004 0.025 0.2915
Echinococcus granulosus L aminoadipate semialdehyde 0.0099 0.0915 0.2112
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.0354 1
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.004 0.025 0.0193
Schistosoma mansoni hypothetical protein 0.0151 0.1484 0.8464
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0076 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0076 0.0046
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0056 0.0427 1
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.0354 0.4953
Mycobacterium tuberculosis Probable ATP synthase beta chain AtpD 0.0039 0.0246 0.5111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0221 0.0403
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0151 0.1484 0.1435
Brugia malayi nuclear hormone receptor 0.0024 0.0076 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0076 0.0046
Echinococcus granulosus vacuolar ATP synthase subunit b 0.004 0.025 0.0474
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.0686 0.155
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0076 0.0019
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0076 0.0046
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0076 0.0046
Echinococcus granulosus ATP synthase subunit alpha mitochondrial 0.0039 0.0246 0.0466
Mycobacterium leprae PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA 0.0039 0.0246 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0076 0.0046
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0032 0.0169 0.2138
Echinococcus multilocularis thyroid hormone receptor alpha 0.0175 0.1754 0.1706
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.004 0.025 0.3369
Schistosoma mansoni ATP synthase alpha subunit mitochondrial 0.0039 0.0246 0.1405
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0118 0.1649
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.0686 0.3914
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.004 0.025 0.2915
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0076 0.0046
Trichomonas vaginalis DNA polymerase eta, putative 0.0049 0.0354 0.4497
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0076 0.0046
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0099 0.0915 0.2112
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0088 0.048
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.0354 0.4953
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0056 0.0427 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0076 0.0046
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.0686 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0354 0.4715
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0076 0.0046
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0118 0.3173
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0266 0.3619
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0076 0.0019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0088 0.0816
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.004 0.025 0.0474
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0354 0.4715
Treponema pallidum V-type ATP synthase subunit B 0.004 0.025 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0076 0.0046
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.2779 0.2738
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0123 0.1172 0.6681
Entamoeba histolytica V-type ATPase, B subunit, putative 0.004 0.025 0.3056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Brugia malayi ecdysteroid receptor 0.0024 0.0076 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0427 0.3647
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0088 0.0909
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0118 0.3226
Chlamydia trachomatis V-type ATP synthase subunit B 0.004 0.025 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0076 0.0046
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0717 1
Schistosoma mansoni ap endonuclease 0.0022 0.0057 0.0327
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0049 0.0354 0.4497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0076 0.0046
Echinococcus granulosus dna polymerase kappa 0.0049 0.0354 0.0731
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0056 0.0427 0.0911
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0076 0.0434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0427 0.0372
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0427 0.0372
Leishmania major DNA polymerase kappa, putative 0.0025 0.0088 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0076 0.0019
Loa Loa (eye worm) isocitrate dehydrogenase 0.0056 0.0427 0.0911
Onchocerca volvulus ATP synthase subunit alpha, mitochondrial homolog 0.0039 0.0246 0.2031
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0118 0.2056
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0123 0.1172 0.2745
Brugia malayi nuclear receptor NHR-88 0.0024 0.0076 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0717 0.4088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0076 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0076 0.0046
Brugia malayi vacuolar ATP synthase subunit B 0.004 0.025 0.0474
Trypanosoma brucei unspecified product 0.0041 0.0266 0.3619
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.0686 0.155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0076 0.0046
Entamoeba histolytica hypothetical protein 0.0028 0.0118 0.097
Leishmania major ATPase alpha subunit 0.0032 0.0169 0.1767
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0354 0.4953
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0118 0.1377
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0076 0.0434
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.004 0.025 0.5197
Toxoplasma gondii exonuclease III APE 0.0022 0.0057 0.049

Activities

Activity type Activity value Assay description Source Reference
PFA (functional) 0 mg kg-1 Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 10 (mg/kg); not significantly different from negative control group ChEMBL. 2562852

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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