TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.401 | Formula: C23H18N2O2
H donors: 2 H acceptors: 3 LogP: 5.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)Nc1ccc2c(c1)nc(cc2C(=O)O)c1ccccc1
InChi: 1S/C23H18N2O2/c1-15-7-9-17(10-8-15)24-18-11-12-19-20(23(26)27)14-21(25-22(19)13-18)16-5-3-2-4-6-16/h2-14,24H,1H3,(H,26,27)
InChiKey: KSNDYJVIBQYADE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Brugia malayi	ORL1-like opioid receptor	0.0057	0.0301	0.0238
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0301	0.0125
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0202	0.1461	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Onchocerca volvulus	Fxna peptidase homolog	0.0202	0.1461	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0268	0.026
Onchocerca volvulus	Fxna peptidase homolog	0.0202	0.1461	0.1406
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0202	0.1461	0.1306
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0301	0.0125
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0057	0.0301	0.0125
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0064	0.0382
Schistosoma mansoni	opsin-like receptor	0.0057	0.0301	0.0125
Brugia malayi	neuropeptide F receptor	0.0057	0.0301	0.0238
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0939	0.7348	0.73
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Brugia malayi	sulfakinin receptor protein	0.0057	0.0301	0.0238
Leishmania major	hypothetical protein, conserved	0.0202	0.1461	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0057	0.0301	0.0125
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	histamine h1 receptor	0.0057	0.0301	0.0125
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0202	0.1461	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0057	0.0301	0.0125
Entamoeba histolytica	hypothetical protein	0.0042	0.0178	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0009	0.5
Schistosoma mansoni	amine GPCR	0.0057	0.0301	0.0125
Brugia malayi	Dopamine receptor protein 1	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0202	0.1461	0.5
Loa Loa (eye worm)	hypothetical protein	0.1271	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.1271	1	1
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0202	0.1461	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1461	0.1453
Trichomonas vaginalis	conserved hypothetical protein	0.0202	0.1461	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0064	0.0382
Echinococcus multilocularis	neuropeptide s receptor	0.0057	0.0301	0.0125
Mycobacterium tuberculosis	Conserved protein	0.0202	0.1461	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0057	0.0301	0.0238
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0301	0.0125
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0064	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0057	0.0301	0.0125
Echinococcus granulosus	tumor protein p63	0.0391	0.2971	0.2844
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.1271	1	1
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.1271	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	neuropeptide receptor A26	0.0057	0.0301	0.0125
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0202	0.1461	0.1306
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0057	0.0301	0.0125
Schistosoma mansoni	amine GPCR	0.0057	0.0301	0.0125
Echinococcus granulosus	sex peptide receptor	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus granulosus	dro:myosuppressin receptor	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Toxoplasma gondii	peptidase, M28 family protein	0.0202	0.1461	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0301	0.0125
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0301	0.0125
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0064	0.0056
Schistosoma mansoni	hypothetical protein	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Onchocerca volvulus		0.0057	0.0301	0.0238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0301	0.0125
Entamoeba histolytica	hypothetical protein	0.0042	0.0178	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0301	0.0125
Brugia malayi	G-protein coupled receptor	0.0057	0.0301	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0057	0.0301	0.0125
Schistosoma mansoni	hypothetical protein	0.0057	0.0301	0.0125
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0057	0.0301	0.0292
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0057	0.0301	0.0125
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0057	0.0301	0.0238
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0057	0.0301	0.0125
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0064	0.0382
Echinococcus granulosus	allatostatin A receptor	0.0057	0.0301	0.0125
Onchocerca volvulus	Fxna peptidase homolog	0.0202	0.1461	0.1406
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0303	0.0127
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0301	0.0292
Brugia malayi	neuropeptide F receptor	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Onchocerca volvulus		0.0202	0.1461	0.1406
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0057	0.0301	0.0292
Brugia malayi	GnHR receptor homolog	0.0057	0.0301	0.0238
Onchocerca volvulus		0.0057	0.0301	0.0238
Brugia malayi	follicle stimulating hormone receptor	0.0057	0.0301	0.0238
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0064	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0268	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	orexin receptor type 2	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	growth hormone secretagogue receptor	0.0057	0.0301	0.0125
Entamoeba histolytica	hypothetical protein	0.0042	0.0178	1
Echinococcus multilocularis	serotonin receptor	0.0057	0.0301	0.0125
Brugia malayi	Serotonin receptor	0.0057	0.0301	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0268	0.0205
Onchocerca volvulus		0.0057	0.0301	0.0238
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0009	0.5
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0202	0.1461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0301	0.0125
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0057	0.0301	0.0238
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0064	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	7tm_1 domain containing protein	0.0057	0.0301	0.0125
Loa Loa (eye worm)	leucyl aminopeptidase	0.0202	0.1461	0.1453
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0303	0.0294
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0057	0.0301	0.0238
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0202	0.1461	0.1306
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0301	0.0125
Brugia malayi	RE15519p	0.0057	0.0301	0.0238
Echinococcus multilocularis	tumor protein p63	0.0391	0.2971	0.2844
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Entamoeba histolytica	hypothetical protein	0.0042	0.0178	1
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Leishmania major	glutaminyl cyclase, putative	0.0202	0.1461	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	somatostatin receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	opsin-like receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	G protein coupled receptor 139	0.0057	0.0301	0.0125
Brugia malayi	FXNA	0.0202	0.1461	0.1406
Echinococcus multilocularis	neuropeptide receptor A26	0.0057	0.0301	0.0125
Loa Loa (eye worm)	melatonin receptor type 1A	0.0057	0.0301	0.0292
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0268	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0202	0.1461	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0301	0.0125
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	nicalin (M28 family)	0.0202	0.1461	0.1306
Brugia malayi	hypothetical protein	0.0042	0.0178	0.0114
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0057	0.0301	0.0125
Onchocerca volvulus	Glutaminyl cyclase homolog	0.1271	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0301	0.0125
Brugia malayi	Dopamine receptor	0.0057	0.0301	0.0238
Onchocerca volvulus		0.0057	0.0301	0.0238
Brugia malayi	putative neuropeptide receptor	0.0057	0.0301	0.0238
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0268	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	Melatonin receptor type 1A	0.0057	0.0301	0.0238
Schistosoma mansoni	hypothetical protein	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	larval opioid receptor	0.0057	0.0301	0.0238
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0057	0.0301	0.0125
Schistosoma mansoni	amine GPCR	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0303	0.024
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0301	0.0125
Brugia malayi	AKH receptor	0.0057	0.0301	0.0238
Echinococcus granulosus	g-protein coupled receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0057	0.0301	0.0125
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0064	0.0441
Schistosoma mansoni	hypothetical protein	0.0057	0.0301	0.0125
Brugia malayi	nicalin	0.0202	0.1461	0.1406
Schistosoma mansoni	neuropeptide f receptor 76f	0.0057	0.0301	0.0125
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0057	0.0301	0.0238
Loa Loa (eye worm)	TYRA-2 protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	fmrfamide receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus multilocularis	serotonin receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0268	0.0092
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0301	0.0125
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0057	0.0301	0.0238
Echinococcus granulosus	neuropeptide FF receptor 2	0.0057	0.0301	0.0125
Schistosoma mansoni	adenoreceptor	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0301	0.0292
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0301	0.0125
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus multilocularis	G protein coupled receptor 139	0.0057	0.0301	0.0125
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1461	0.1453
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0064	0.0382
Schistosoma mansoni	amine GPCR	0.0057	0.0301	0.0125
Schistosoma mansoni	opsin-like receptor	0.0057	0.0301	0.0125
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Onchocerca volvulus		0.0057	0.0301	0.0238
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0064	0.0441
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0202	0.1461	0.1306
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0009	0.0061
Mycobacterium ulcerans	hypothetical protein	0.0202	0.1461	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0301	0.0125
Toxoplasma gondii	hypothetical protein	0.0202	0.1461	0.5
Brugia malayi	Dopamine receptor protein 2	0.0057	0.0301	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1461	0.1453
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus granulosus	neuropeptide s receptor	0.0057	0.0301	0.0125
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0301	0.0125
Echinococcus multilocularis	g-protein coupled receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0301	0.0125
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0301	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0202	0.1461	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0064	0.0382
Echinococcus granulosus	somatostatin receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0202	0.1461	0.5
Schistosoma mansoni	myosin xvIII	0.0057	0.0301	0.0125
Onchocerca volvulus		0.0057	0.0301	0.0238
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0202	0.1461	0.1306
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0268	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0301	0.0125
Brugia malayi	leucyl aminopeptidase	0.0202	0.1461	0.1406
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0202	0.1461	0.1306
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0057	0.0301	0.0292
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0268	0.0092
Trypanosoma brucei	glutaminyl cyclase, putative	0.0202	0.1461	0.5
Echinococcus multilocularis	sex peptide receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0064	0.0056
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0064	0.0382
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0057	0.0301	0.0125
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1461	0.1453
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0057	0.0301	0.0125
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0057	0.0301	0.0292
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0301	0.0125
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0057	0.0301	0.0125
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0064	0.0056
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0301	0.0125
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0064	0.0382
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0057	0.0301	0.0238
Echinococcus granulosus	serotonin receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	amine GPCR	0.0057	0.0301	0.0125
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0301	0.0292
Echinococcus multilocularis	orexin receptor type 2	0.0057	0.0301	0.0125
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0202	0.1461	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0268	0.0092
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0057	0.0301	0.0125
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0301	0.0125
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0009	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	G protein-coupled receptor	0.0057	0.0301	0.0238
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0057	0.0301	0.0292
Echinococcus granulosus	hypothetical protein	0.0057	0.0301	0.0125
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	Serotonin receptor	0.0057	0.0301	0.0238
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0301	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Brugia malayi	hypothetical protein	0.0057	0.0301	0.0238
Brugia malayi	G-protein coupled receptor	0.0057	0.0301	0.0238
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0301	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0301	0.0292
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0301	0.0125
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0301	0.0125

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 8 mm	Antibacterial activity against Escherichia coli MTCC 1652 at 10 ug/well after 24 hr by agar well diffusion method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2263040

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1844154