Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0127 | 0.1355 | 1 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0127 | 0.1355 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1672 | 0.1672 |
Schistosoma mansoni | nicalin (M28 family) | 0.0127 | 0.1355 | 0.1355 |
Brugia malayi | PAS domain containing protein | 0.0071 | 0.0627 | 0.0627 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0256 | 0.0256 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.08 | 1 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0052 | 0.0391 | 0.2886 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.08 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0626 | 0.0626 |
Onchocerca volvulus | 0.0152 | 0.1672 | 0.1326 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0127 | 0.1355 | 0.1355 |
Brugia malayi | FXNA | 0.0127 | 0.1355 | 0.1355 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0127 | 0.1355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0127 | 0.1355 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.0626 | 0.4617 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0256 | 0.0256 |
Echinococcus granulosus | single minded 2 | 0.0052 | 0.0391 | 0.0391 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0127 | 0.1355 | 0.0996 |
Brugia malayi | leucyl aminopeptidase | 0.0127 | 0.1355 | 0.1355 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.08 | 1 | 1 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0127 | 0.1355 | 0.1355 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0127 | 0.1355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1355 | 0.1355 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0152 | 0.168 | 0.168 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0127 | 0.1355 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0127 | 0.1355 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1355 | 0.1355 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0256 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0127 | 0.1355 | 0.1355 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0256 | 0.0256 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0626 | 0.4617 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0127 | 0.1355 | 0.0996 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.0626 | 0.0626 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0152 | 0.168 | 0.168 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.1355 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0127 | 0.1355 | 0.1355 |
Schistosoma mansoni | single-minded | 0.0071 | 0.0627 | 0.0627 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0127 | 0.1355 | 0.1355 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0626 | 0.0626 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.0626 | 0.4617 |
Brugia malayi | bHLH-PAS transcription factor | 0.0052 | 0.0391 | 0.0391 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0134 | 0.1436 | 0.1436 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0256 | 0.0256 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0205 | 0.2352 | 0.2352 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1355 | 0.1355 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0127 | 0.1355 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0127 | 0.1355 | 0.1355 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0127 | 0.1355 | 0.1355 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0626 | 0.4617 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0256 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0127 | 0.1355 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.08 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0127 | 0.1355 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.0626 | 0.4617 |
Mycobacterium tuberculosis | Conserved protein | 0.0127 | 0.1355 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0127 | 0.1355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1444 | 0.1444 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0127 | 0.1355 | 0.0996 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0256 | 0.0256 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0127 | 0.1355 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0052 | 0.0391 | 0.0391 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.0626 | 0.0626 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0256 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0127 | 0.1355 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0127 | 0.1355 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.0626 | 0.4617 |
Brugia malayi | nicalin | 0.0127 | 0.1355 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1436 | 0.1436 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1355 | 0.1355 |
Onchocerca volvulus | 0.0127 | 0.1355 | 0.0996 | |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0256 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0127 | 0.1355 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of Mus musculus (mouse) glutamate cysteine ligase isolated from liver at 200 uM | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of Mus musculus (mouse) glutathione reductase isolated from liver at 200 uM | ChEMBL. | No reference | |
Inhibition (binding) | = 27 % | Inhibition of Setaria cervi glutamate cysteine ligase using glutamate as substrate at 200 uM incubated for 10 min prior to substrate addition measured for 5 min by spectrophotometric analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.