TDR Targets

Basic information

Technical information

TDR Targets ID: 1845767
Name: 1-[(6-chloropyridin-3-yl)methyl]-8-nitro-5-(2 ,2,2-trifluoroethoxy)-3,5,6,7-tetrahydro-2H-i midazo[1,2-a]pyridine
MW: 392.761 | Formula: C15H16ClF3N4O3
H donors: 0 H acceptors: 3 LogP: 3.48 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cn1)CN1CCN2C1=C(CCC2OCC(F)(F)F)[N+](=O)[O-]
InChi: 1S/C15H16ClF3N4O3/c16-12-3-1-10(7-20-12)8-21-5-6-22-13(26-9-15(17,18)19)4-2-11(14(21)22)23(24)25/h1,3,7,13H,2,4-6,8-9H2
InChiKey: JLXRCUNAZLLGTO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

1-[(6-chloro-3-pyridyl)methyl]-8-nitro-5-(2,2,2-trifluoroethoxy)-3,5,6,7-tetrahydro-2H-imidazo[1,2-a]pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	enteropeptidase	0.0016	0.0248	0.1099
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.8651
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.9752
Plasmodium falciparum	protein kinase 7	0.0288	0.6612	0.6612
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2978
Onchocerca volvulus		0.0016	0.0248	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0582	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0597	0.2648
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.3724	0.3724
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2253	0.3408
Echinococcus granulosus	General substrate transporter	0.0088	0.1918	0.851
Onchocerca volvulus		0.0016	0.0248	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0016	0.0248	0.1099
Brugia malayi	Trypsin-like protease protein 5	0.0016	0.0248	0.1099
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Leishmania major	protein kinase, putative	0.0031	0.0597	0.8517
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0248	0.6214
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.2583
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.3724	0.3724
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0597	0.0597
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0201	0.6328
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0201	0.2874
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0016	0.0248	0.1099
Brugia malayi	Trypsin family protein	0.0016	0.0248	0.1099
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.3724	0.5632
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0201	0.5052
Onchocerca volvulus		0.0016	0.0248	1
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0597	0.0597
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0201	0.2874
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0597	0.2648
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0582	1
Plasmodium falciparum	hexose transporter	0.0102	0.2253	0.2253
Echinococcus granulosus	enteropeptidase	0.0016	0.0248	0.1099
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Schistosoma mansoni	glucose transport protein	0.0102	0.2253	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0433	1	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	General substrate transporter	0.0088	0.1918	0.851
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Brugia malayi	Sugar transporter family protein	0.0102	0.2253	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Giardia lamblia	Sugar-proton symporter	0.0014	0.0201	0.346
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.2583
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Schistosoma mansoni	hypothetical protein	0.0016	0.0248	0.1099
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0201	0.0305
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.8651
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0016	0.0248	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Plasmodium vivax	sugar transporter, putative	0.0014	0.0201	0.0201
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	glycoprotein Antigen 5	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.6849
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0894
Brugia malayi	Trypsin family protein	0.0016	0.0248	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0201	0.2874
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0597	0.0903
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0597	0.8517
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.1987
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	Mastin	0.0016	0.0248	0.1099
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.2583
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0201	0.0305
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0597	0.0903
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0701	0.106
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0248	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0201	0.0201
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0201	1
Onchocerca volvulus		0.0016	0.0248	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0597	0.0903
Plasmodium vivax	hexose transporter	0.0102	0.2253	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.2583
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.2583
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.8651
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0318	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Schistosoma mansoni	glucose transport protein	0.0102	0.2253	1
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0201	0.0305
Schistosoma mansoni	glucose transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	trypsin family protein	0.0016	0.0248	0.1099
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0552	0.2448
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Toxoplasma gondii	protein kinase, putative	0.0288	0.6612	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0014	0.0201	0.0894
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.8651
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.2583
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	hypothetical protein	0.0102	0.2253	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Giardia lamblia	Hexose transporter	0.0014	0.0201	0.346
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0597	0.2648
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0597	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.2583
Brugia malayi	Cam kinase protein 1	0.0031	0.0597	0.2648
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0597	0.0597
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0597	0.0597
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0597	0.2648
Schistosoma mansoni	glucose transport protein	0.0102	0.2253	1
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Onchocerca volvulus		0.0016	0.0248	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.1769
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0552	0.2448
Brugia malayi	Trypsin family protein	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.1769
Loa Loa (eye worm)	sugar transporter	0.0102	0.2253	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2253	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0709
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	glycoprotein Antigen 5	0.0016	0.0248	0.1099
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0248	0.1099
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.027	0.386
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Mycobacterium ulcerans	sugar transporter	0.0014	0.0201	0.5052
Brugia malayi	Trypsin family protein	0.0016	0.0248	0.1099
Schistosoma mansoni	hypothetical protein	0.0016	0.0248	0.1099
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Leishmania major	hypothetical protein, conserved	0.0014	0.0201	0.2874
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.6679
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.8651
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0894
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0201	0.6328
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0201	0.2874
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.8651
Brugia malayi	hypothetical protein	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	Mastin	0.0016	0.0248	0.1099
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2253	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0201	0.5052
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Echinococcus granulosus	transmembrane protease serine 3	0.0016	0.0248	0.1099
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0597	0.0597
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0597	0.0597
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0248	0.1099
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.2583
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0248	0.1099
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0597	0.0597
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Echinococcus multilocularis	transmembrane protease serine 3	0.0016	0.0248	0.1099
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.5469

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2253535

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1845767