Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 0.1612 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0102 | 0.1612 | 0.1612 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0102 | 0.1612 | 0.5 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0102 | 0.1612 | 0.1612 |
Onchocerca volvulus | 0.0593 | 1 | 1 | |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0102 | 0.1612 | 1 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.8262 | 1 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0102 | 0.1612 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0573 | 0.0573 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0102 | 0.1612 | 0.1951 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0087 | 0.0105 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Onchocerca volvulus | 0.0593 | 1 | 1 | |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0087 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1612 | 0.1612 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0102 | 0.1612 | 0.1951 |
Toxoplasma gondii | flagellar/basal body protein | 0.0102 | 0.1612 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0087 | 0.0105 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0593 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0059 | 0.0059 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0059 | 0.0365 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0514 | 0.0514 |
Echinococcus multilocularis | 0.0102 | 0.1612 | 0.1612 | |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0514 | 0.0514 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0102 | 0.1612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0102 | 0.1612 | 0.1612 |
Plasmodium vivax | hypothetical protein, conserved | 0.0102 | 0.1612 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0087 | 0.0105 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0102 | 0.1612 | 0.1612 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0102 | 0.1612 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0472 | 0.2929 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0102 | 0.1612 | 0.1951 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0059 | 0.0059 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0593 | 1 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0025 | 0.0031 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0059 | 0.0059 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0102 | 0.1612 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0102 | 0.1612 | 1 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0102 | 0.1612 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0102 | 0.1612 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.043 | 0.052 |
Onchocerca volvulus | 0.0593 | 1 | 1 | |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 0.1612 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0102 | 0.1612 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0514 | 0.0622 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0102 | 0.1612 | 0.1612 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | peptidase | 0.0102 | 0.1612 | 0.1612 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0087 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Onchocerca volvulus | 0.0593 | 1 | 1 | |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0102 | 0.1612 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0102 | 0.1612 | 1 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0102 | 0.1612 | 0.5 |
Schistosoma mansoni | peptidase | 0.0102 | 0.1612 | 0.1612 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0102 | 0.1612 | 0.1612 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0102 | 0.1612 | 1 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0102 | 0.1612 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0059 | 0.0071 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0102 | 0.1612 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0102 | 0.1612 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0472 | 0.2929 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0102 | 0.1612 | 0.1951 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0102 | 0.1612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0059 | 0.0059 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.0087 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0514 | 0.3191 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0102 | 0.1612 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0059 | 0.0059 |
Schistosoma mansoni | peptidase | 0.0102 | 0.1612 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1612 | 0.1951 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0573 | 0.0573 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as minimal motor impairment at 300 mg/kg, ip after 0.5 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity in Mus musculus (mouse) assessed as minimal motor impairment at 300 mg/kg, ip after 4 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | = 21.66 % | Neurotoxicity in Mus musculus (mouse) assessed as increase in immobility time at 30 mg/kg, ip administered 30 min before test measured for 5 min by forced swimming test | ChEMBL. | No reference |
MED (functional) | = 30 mg kg-1 | Anticonvulsant activity in ip dosed Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizure after 0.5 hr | ChEMBL. | No reference |
MED (functional) | = 30 mg kg-1 | Anticonvulsant activity in ip dosed Mus musculus (mouse) assessed as protection against subcutaneous pentylene tetrazole-induced seizure after 4 hr | ChEMBL. | No reference |
MED (functional) | = 30 mg kg-1 | Anticonvulsant activity in ip dosed Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizure after 4 hr | ChEMBL. | No reference |
MED (functional) | = 100 mg kg-1 | Anticonvulsant activity in ip dosed Mus musculus (mouse) assessed as protection against subcutaneous pentylene tetrazole-induced seizure after 0.5 hr | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.