Detailed information for compound 1846841

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 805.941 | Formula: C40H56FN11O6
  • H donors: 8 H acceptors: 6 LogP: 1.8 Rotable bonds: 28
    Rule of 5 violations (Lipinski): 3
  • SMILES: C/C=C/C=C/CC(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCN=C(N)N)CC(C)C)Cc1ccc(cc1)NC(=N)N)Cc1ccc(cc1)F)C(=O)C
  • InChi: 1S/C40H56FN11O6/c1-5-6-7-8-11-34(54)52(25(4)53)33(23-27-12-16-28(41)17-13-27)38(58)51-32(22-26-14-18-29(19-15-26)48-40(45)46)37(57)50-31(21-24(2)3)36(56)49-30(35(42)55)10-9-20-47-39(43)44/h5-8,12-19,24,30-33H,9-11,20-23H2,1-4H3,(H2,42,55)(H,49,56)(H,50,57)(H,51,58)(H4,43,44,47)(H4,45,46,48)/b6-5+,8-7+/t30-,31-,32-,33-/m0/s1
  • InChiKey: HDPFTJRHEFECLI-BPQGUKOQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0349 0.0349
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0317 0.3911 1
Echinococcus granulosus mitogen activated protein kinase 0.0317 0.3911 0.4798
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0317 0.3911 1
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0317 0.3911 1
Schistosoma mansoni microtubule-associated protein tau 0.0646 0.815 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0061 0.0156
Schistosoma mansoni hypothetical protein 0.004 0.033 0.0404
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0059 0.0581 0.1487
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0281 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1054 0.1294
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0437 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1473 0.1807
Loa Loa (eye worm) hypothetical protein 0.0096 0.1054 0.2696
Giardia lamblia Kinase, CMGC MAPK 0.0317 0.3911 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1074 0.1317
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0349 0.0892
Onchocerca volvulus 0.0019 0.0061 0.1051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0349 0.0892
Onchocerca volvulus 0.0048 0.0437 0.7522
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0437 0.1118
Brugia malayi MAP kinase sur-1 0.0317 0.3911 1
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.028 0.0717
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0437 0.4148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0256 0.5844
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0317 0.3911 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0437 0.1118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0371 0.0947
Loa Loa (eye worm) hypothetical protein 0.0052 0.0489 0.125
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0061 0.0156
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0489 0.06
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0494 0.1264
Onchocerca volvulus 0.0019 0.0061 0.1051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0317 0.3911 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0045 0.1035
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0317 0.3911 1
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0032 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Toxoplasma gondii exonuclease III APE 0.0018 0.0045 0.0116
Echinococcus multilocularis expressed conserved protein 0.009 0.0979 0.0979
Loa Loa (eye worm) hypothetical protein 0.0048 0.0437 0.1118
Trichomonas vaginalis CMGC family protein kinase 0.0317 0.3911 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0061 0.0156
Echinococcus multilocularis microtubule associated protein 2 0.0646 0.815 0.815
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0045 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0123 0.2108
Toxoplasma gondii hypothetical protein 0.0019 0.0061 0.0156
Echinococcus multilocularis protein patched 0.0041 0.0349 0.0349
Echinococcus multilocularis mitogen activated protein kinase 0.0317 0.3911 0.3911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0256 0.5844
Echinococcus multilocularis tar DNA binding protein 0.0128 0.1473 0.1473
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0123 0.0313
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0061 0.0156
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1054 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.0718
Onchocerca volvulus 0.0019 0.0061 0.1051
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0437 1
Onchocerca volvulus 0.0059 0.0581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0371 0.0455
Trichomonas vaginalis CMGC family protein kinase 0.0317 0.3911 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0061 0.0156
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1054 0.1054
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0437 0.1118
Echinococcus granulosus tissue type plasminogen activator 0.0059 0.0581 0.0713
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0032 0.0082
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0281 0.6421
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0045 0.5
Onchocerca volvulus 0.0019 0.0061 0.1051
Loa Loa (eye worm) TAR-binding protein 0.0128 0.1473 0.3765
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0045 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0123 0.2108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0082
Brugia malayi hypothetical protein 0.0024 0.0123 0.0313
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.1473 0.3765
Echinococcus multilocularis tissue type plasminogen activator 0.0059 0.0581 0.0581
Echinococcus multilocularis tumor protein p63 0.0355 0.44 0.44
Brugia malayi CHE-14 protein 0.0041 0.0349 0.0892
Mycobacterium ulcerans hypothetical protein 0.0048 0.0437 1
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1317 0.3368
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0281 0.6421
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0045 0.5
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1317 0.3368
Trichomonas vaginalis CMGC family protein kinase 0.0317 0.3911 1
Onchocerca volvulus 0.0019 0.0061 0.1051
Echinococcus multilocularis protein dispatched 1 0.0047 0.0424 0.0424
Toxoplasma gondii microneme protein MIC4 0.0019 0.0061 0.0156
Echinococcus granulosus expressed conserved protein 0.009 0.0979 0.1202
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0045 0.0116
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0061 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.3911 0.4798
Onchocerca volvulus 0.0052 0.0489 0.8407
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1473 0.1807
Echinococcus granulosus tumor protein p63 0.0355 0.44 0.5398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0371 0.0455
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0045 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0437 1
Onchocerca volvulus 0.0019 0.0061 0.1051
Schistosoma mansoni hypothetical protein 0.004 0.033 0.0404
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1585 0.1945
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0061 0.0156
Echinococcus multilocularis mitogen activated protein kinase 3 0.0317 0.3911 0.3911
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0061 0.0156
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Onchocerca volvulus 0.0019 0.0061 0.1051
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0317 0.3911 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0371 0.0455
Brugia malayi Protein kinase domain containing protein 0.0059 0.0581 0.1487
Loa Loa (eye worm) hypothetical protein 0.0059 0.0581 0.1487
Loa Loa (eye worm) RNA binding protein 0.0128 0.1473 0.3765
Toxoplasma gondii microneme protein, putative 0.0019 0.0061 0.0156
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0045 0.0116
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0281 0.483
Schistosoma mansoni hypothetical protein 0.0059 0.0581 0.0713
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0045 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0045 0.0779
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0437 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0059 0.0581 0.1487
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0045 0.0116
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0032 0.0082
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0317 0.3911 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0039
Onchocerca volvulus 0.0019 0.0061 0.1051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.0718
Toxoplasma gondii subtilisin SUB12 0.0019 0.0061 0.0156
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0123 0.0313
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0052 0.0494 0.1264
Brugia malayi MH2 domain containing protein 0.0116 0.1317 0.3368
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0123 0.2108
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0045 0.0045
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0581 0.1487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0256 0.5844
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0123 0.0313
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.1473 0.3765
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0371 0.0455
Trypanosoma brucei protein kinase, putative 0.0317 0.3911 1
Schistosoma mansoni hypothetical protein 0.0036 0.028 0.0344
Brugia malayi Cytochrome P450 family protein 0.0046 0.0407 0.1041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0045 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0437 0.4148
Brugia malayi TAR-binding protein 0.0128 0.1473 0.3765
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0059 0.0581 1
Schistosoma mansoni hypothetical protein 0.004 0.033 0.0404
Schistosoma mansoni ap endonuclease 0.0018 0.0045 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0437 0.1118
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0349 0.0428
Brugia malayi Kringle domain containing protein 0.0059 0.0581 0.1487
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.0718
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0045 0.043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0437 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0437 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0437 0.1118
Toxoplasma gondii kringle domain-containing protein 0.0059 0.0581 0.1487
Trichomonas vaginalis CMGC family protein kinase 0.0317 0.3911 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0494 0.1264
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0045 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0437 0.1118
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0371 0.0947
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0407 0.1041
Plasmodium falciparum cysteine repeat modular protein 1 0.0059 0.0581 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0437 0.1118
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0061 0.0156
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1585 0.1585
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1473 0.1807
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0281 0.483
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0045 0.1035
Onchocerca volvulus 0.0019 0.0061 0.1051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0494 0.1264
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.0718
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0123 0.0313
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1473 0.1807
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0349 0.0892
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0061 0.0156
Echinococcus granulosus microtubule associated protein 2 0.0646 0.815 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0317 0.3911 0.4798
Toxoplasma gondii PAN domain-containing protein 0.0293 0.3592 0.9185
Loa Loa (eye worm) hypothetical protein 0.005 0.0468 0.1197
Echinococcus granulosus tar DNA binding protein 0.0128 0.1473 0.1807
Schistosoma mansoni ap endonuclease 0.0018 0.0045 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0437 1
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0039
Brugia malayi RNA binding protein 0.0128 0.1473 0.3765
Loa Loa (eye worm) hypothetical protein 0.0036 0.028 0.0717
Schistosoma mansoni patched 1 0.0041 0.0349 0.0428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0371 0.0371
Onchocerca volvulus 0.0019 0.0061 0.1051
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0437 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0371 0.0455
Brugia malayi hypothetical protein 0.0015 0.0015 0.0038
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0437 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.0718
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0061 0.0156
Echinococcus multilocularis GPCR, family 2 0.0017 0.0032 0.0032
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1054 0.2696
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Onchocerca volvulus 0.0019 0.0061 0.1051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0032
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0349 0.0428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0371 0.0371
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0039
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0024 0.0123 0.0313
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0039
Echinococcus granulosus GPCR family 2 0.0017 0.0032 0.0039
Toxoplasma gondii hypothetical protein 0.0019 0.0061 0.0156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0256 0.5844
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0437 1
Schistosoma mansoni hypothetical protein 0.004 0.033 0.0404
Leishmania major hypothetical protein, conserved 0.0024 0.0123 0.0313
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1473 0.1807
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0437 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0048 0.0437 0.1118
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0039
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0437 0.4148
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0317 0.3911 1
Toxoplasma gondii PAN domain-containing protein 0.0293 0.3592 0.9185
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0045 0.0779
Brugia malayi PAN domain containing protein 0.0019 0.0061 0.0156

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) uM Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%; PA=not experimentally achieved ChEMBL. 8960546
IC50 (binding) = 0.024 uM Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay ChEMBL. 8960546

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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