Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Brugia malayi | hypothetical protein | 0.0277 | 0.1604 | 0.2633 |
Trichomonas vaginalis | trehalase, putative | 0.0277 | 0.1604 | 0.952 |
Schistosoma mansoni | alpha-glucosidase | 0.0563 | 0.4031 | 0.6617 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0806 | 0.6092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0065 | 0.0065 |
Brugia malayi | trehalase | 0.0096 | 0.0065 | 0.0106 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.0933 | 0.5539 |
Brugia malayi | Trehalase family protein | 0.0277 | 0.1604 | 0.2633 |
Leishmania major | glycosyl hydrolase, putative | 0.0134 | 0.0391 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0563 | 0.4031 | 0.6617 |
Mycobacterium leprae | Possible hydrolase | 0.0134 | 0.0391 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0576 | 0.4142 | 0.6799 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0563 | 0.4031 | 0.6617 |
Loa Loa (eye worm) | trehalase | 0.0277 | 0.1604 | 0.1604 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0065 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.4566 | 0.4566 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0576 | 0.4142 | 0.6799 |
Loa Loa (eye worm) | trehalase | 0.0277 | 0.1604 | 0.1604 |
Onchocerca volvulus | Trehalase homolog | 0.0277 | 0.1604 | 0.4688 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1604 | 0.1604 |
Schistosoma mansoni | alpha-glucosidase | 0.0563 | 0.4031 | 0.6617 |
Plasmodium vivax | hypothetical protein, conserved | 0.0191 | 0.0873 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0287 | 0.1685 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0806 | 0.6092 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0563 | 0.4031 | 0.6617 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Echinococcus multilocularis | beta galactosidase | 0.0626 | 0.4566 | 0.7495 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0806 | 0.6092 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0287 | 0.1685 | 1 |
Loa Loa (eye worm) | TRE-1 protein | 0.0277 | 0.1604 | 0.1604 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0806 | 0.6092 | 1 |
Onchocerca volvulus | 0.0378 | 0.2462 | 1 | |
Treponema pallidum | hypothetical protein | 0.0096 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0065 | 0.0065 |
Brugia malayi | Trehalase family protein | 0.0096 | 0.0065 | 0.0106 |
Loa Loa (eye worm) | trehalase | 0.0096 | 0.0065 | 0.0065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0287 | 0.1685 | 1 |
Onchocerca volvulus | 0.0277 | 0.1604 | 0.4688 | |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0576 | 0.4142 | 0.6799 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0563 | 0.4031 | 0.4031 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0287 | 0.1685 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0277 | 0.1604 | 0.952 |
Toxoplasma gondii | melibiase subfamily protein | 0.0088 | 0 | 0.5 |
Onchocerca volvulus | 0.0277 | 0.1604 | 0.4688 | |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0321 | 0.1973 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0287 | 0.1685 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0806 | 0.6092 | 1 |
Loa Loa (eye worm) | TRE-2 protein | 0.0277 | 0.1604 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.6092 | 0.6092 |
Brugia malayi | Trehalase family protein | 0.0277 | 0.1604 | 0.2633 |
Brugia malayi | Trehalase family protein | 0.0096 | 0.0065 | 0.0106 |
Brugia malayi | Trehalase protein 5 | 0.0096 | 0.0065 | 0.0106 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0287 | 0.1685 | 0.1685 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1604 | 0.1604 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0576 | 0.4142 | 0.6799 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0143 | 0.0461 | 0.5 |
Onchocerca volvulus | 0.0277 | 0.1604 | 0.4688 | |
Loa Loa (eye worm) | hypothetical protein | 0.0576 | 0.4142 | 0.4142 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0191 | 0.0873 | 0.5 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0134 | 0.0391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0788 | 0.0788 |
Schistosoma mansoni | amine GPCR | 0.0203 | 0.0975 | 0.16 |
Loa Loa (eye worm) | trehalase | 0.0277 | 0.1604 | 0.1604 |
Brugia malayi | Trehalase family protein | 0.0277 | 0.1604 | 0.2633 |
Loa Loa (eye worm) | trehalase | 0.0096 | 0.0065 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.0576 | 0.4142 | 0.6799 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0576 | 0.4142 | 0.6799 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0065 | 0.0106 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0576 | 0.4142 | 0.6799 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0065 | 0.0106 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0321 | 0.1973 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0287 | 0.1685 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0771 | 0.5793 | 0.9509 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0065 | 0.0065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0198 | 0.0933 | 0.5539 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0065 | 0.0065 |
Brugia malayi | Trehalase family protein | 0.0277 | 0.1604 | 0.2633 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0576 | 0.4142 | 0.4142 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0563 | 0.4031 | 0.6617 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0806 | 0.6092 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0576 | 0.4142 | 0.6799 |
Schistosoma mansoni | hypothetical protein | 0.0576 | 0.4142 | 0.6799 |
Schistosoma mansoni | beta-galactosidase | 0.0626 | 0.4566 | 0.7495 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1604 | 0.1604 |
Onchocerca volvulus | 0.0277 | 0.1604 | 0.4688 | |
Schistosoma mansoni | apoptosis regulator bax | 0.0576 | 0.4142 | 0.6799 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1604 | 0.1604 |
Brugia malayi | trehalase I | 0.0096 | 0.0065 | 0.0106 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0287 | 0.1685 | 0.2766 |
Echinococcus granulosus | beta galactosidase | 0.0626 | 0.4566 | 0.7495 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1604 | 0.1604 |
Onchocerca volvulus | 0.0277 | 0.1604 | 0.4688 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.0847 | 0.5028 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | % | The compound was tested for inhibition of pepsin at the concentration of 10e-5 M; ND means no data | ChEMBL. | 3305946 |
Inhibition (binding) | = 7 % | Inhibition of human renal renin at the concentration of 10e-5 M. | ChEMBL. | 3305946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.