Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0594 | 0.1377 | 0.1129 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.3735 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0594 | 0.1377 | 0.1129 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.3735 | 1 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0594 | 0.1377 | 0.1129 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0594 | 0.1377 | 0.1129 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0594 | 0.1377 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.022 | 0.0349 | 0.0349 |
Mycobacterium ulcerans | hypothetical protein | 0.0594 | 0.1377 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.022 | 0.0349 | 0.0072 |
Brugia malayi | FXNA | 0.0594 | 0.1377 | 0.1129 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.3735 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.0279 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0594 | 0.1377 | 0.1129 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.0279 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.0279 | 0.0279 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0594 | 0.1377 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0594 | 0.1377 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0594 | 0.1377 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0594 | 0.1377 | 0.1129 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0594 | 0.1377 | 0.1129 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0594 | 0.1377 | 0.1129 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0594 | 0.1377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3735 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.3735 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0594 | 0.1377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0279 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0594 | 0.1377 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Onchocerca volvulus | 0.0594 | 0.1377 | 0.1129 | |
Toxoplasma gondii | hypothetical protein | 0.0594 | 0.1377 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0594 | 0.1377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Brugia malayi | nicalin | 0.0594 | 0.1377 | 0.1129 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0594 | 0.1377 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.022 | 0.0349 | 0.0349 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0594 | 0.1377 | 0.1129 |
Leishmania major | hypothetical protein, conserved | 0.0594 | 0.1377 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.0279 | 0.0279 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2 uM | The compound was evaluated for the inhibition of dTMP synthetase from Lactobacillus casei | ChEMBL. | 6796687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.