Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0282 | 0.0282 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0215 | 0.2754 | 0.2865 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0028 | 0 | 0.5 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0181 | 0.132 |
Onchocerca volvulus | Carboxypeptidase D homolog | 0.0121 | 0.1368 | 0.1368 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0121 | 0.1368 | 0.1368 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0223 | 0.0223 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0121 | 0.1368 | 1 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0704 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0662 | 0.9367 | 0.9367 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0121 | 0.1368 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.07 | 0.0728 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0121 | 0.1368 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0181 | 0.132 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.2754 | 0.2754 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0121 | 0.1368 | 0.1368 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0223 | 0.0223 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0389 | 0.533 | 0.5544 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0121 | 0.1368 | 1 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0121 | 0.1368 | 0.5 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0121 | 0.1368 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.07 | 0.07 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0662 | 0.9367 | 0.9367 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.2754 | 0.2865 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0052 |
Toxoplasma gondii | flagellar/basal body protein | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0121 | 0.1368 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0047 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.07 | 0.0728 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.07 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.1368 | 0.1368 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0047 | 0.0271 | 0.0271 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0223 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | RNA binding protein | 0.0076 | 0.07 | 0.0728 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0662 | 0.9367 | 0.9367 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0121 | 0.1368 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.6439 | 0.6698 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0121 | 0.1368 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0215 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0662 | 0.9367 | 0.9367 |
Onchocerca volvulus | 0.0121 | 0.1368 | 0.1368 | |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Plasmodium vivax | hypothetical protein, conserved | 0.0121 | 0.1368 | 1 |
Schistosoma mansoni | peptidase | 0.0121 | 0.1368 | 0.1368 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0215 | 0.2754 | 0.2865 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0662 | 0.9367 | 0.9744 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.07 | 0.07 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.0052 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0104 | 0.112 | 0.8115 |
Loa Loa (eye worm) | hypothetical protein | 0.0678 | 0.9614 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.07 | 0.07 |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0121 | 0.1368 | 0.1368 |
Schistosoma mansoni | peptidase | 0.0121 | 0.1368 | 0.1368 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0464 | 0.6439 | 0.6698 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0121 | 0.1368 | 0.1423 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0223 | 0.0232 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0121 | 0.1368 | 0.1368 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0121 | 0.1368 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0104 | 0.112 | 0.8115 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0215 | 0.2754 | 0.2754 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0121 | 0.1368 | 0.1368 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0138 | 0.0144 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0121 | 0.1368 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.07 | 0.07 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0121 | 0.1368 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0662 | 0.9367 | 0.9744 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0662 | 0.9367 | 0.9367 |
Brugia malayi | MH2 domain containing protein | 0.0389 | 0.533 | 0.5544 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0678 | 0.9614 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.07 | 0.0728 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Schistosoma mansoni | hypothetical protein | 0.0464 | 0.6439 | 0.6439 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0121 | 0.1368 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0052 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.0052 | 0.0052 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0.112 | 0.8115 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0104 | 0.112 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0104 | 0.112 | 0.8115 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0054 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0121 | 0.1368 | 0.1368 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0678 | 0.9614 | 1 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0704 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0662 | 0.9367 | 0.9367 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0121 | 0.1368 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0678 | 0.9614 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0104 | 0.112 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.07 | 0.07 |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0121 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0704 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0215 | 0.2754 | 0.2754 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0215 | 0.2754 | 0.2754 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Onchocerca volvulus | 0.0496 | 0.6916 | 0.6916 | |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.2754 | 0.2754 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0215 | 0.2754 | 0.2865 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0054 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0389 | 0.533 | 0.5544 |
Schistosoma mansoni | peptidase | 0.0121 | 0.1368 | 0.1368 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0104 | 0.112 | 0.8115 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1423 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0215 | 0.2754 | 0.2754 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.07 | 0.07 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0104 | 0.112 | 0.8115 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0121 | 0.1368 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Echinococcus multilocularis | GPCR, family 2 | 0.0215 | 0.2754 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.112 | 0.1165 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0121 | 0.1368 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0574 | 0.0597 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0052 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.07 | 0.07 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.07 | 0.0728 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Echinococcus multilocularis | 0.0121 | 0.1368 | 0.1368 | |
Onchocerca volvulus | Cytosolic carboxypeptidase 1 homolog | 0.0121 | 0.1368 | 0.1368 |
Brugia malayi | hypothetical protein | 0.0104 | 0.112 | 0.1165 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0054 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0662 | 0.9367 | 0.9367 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1368 | 0.1423 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0496 | 0.6916 | 0.7194 |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0121 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0583 | 0.8211 | 0.8541 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0271 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.2754 | 0.2754 |
Brugia malayi | Pax transcription factor protein 2 | 0.0496 | 0.6916 | 0.7194 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.2754 | 0.2754 |
Onchocerca volvulus | 0.0121 | 0.1368 | 0.1368 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0052 | 0.0052 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0121 | 0.1368 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.