Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0499 | 0.1248 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0499 | 0.1248 | 0.1248 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0499 | 0.1248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.1248 | 0.1248 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0499 | 0.1248 | 0.1248 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0499 | 0.1248 | 0.1248 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0499 | 0.1248 | 0.1248 |
Brugia malayi | nicalin | 0.0499 | 0.1248 | 0.1248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0499 | 0.1248 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0499 | 0.1248 | 0.1248 |
Brugia malayi | leucyl aminopeptidase | 0.0499 | 0.1248 | 0.1248 |
Schistosoma mansoni | nicalin (M28 family) | 0.0499 | 0.1248 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.1248 | 0.1248 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0499 | 0.1248 | 0.1248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0499 | 0.1248 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.3134 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0499 | 0.1248 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.3134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.1248 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.1248 | 0.1248 |
Mycobacterium ulcerans | hypothetical protein | 0.0499 | 0.1248 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0499 | 0.1248 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0499 | 0.1248 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0499 | 0.1248 | 0.1248 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.3134 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0499 | 0.1248 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0499 | 0.1248 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0499 | 0.1248 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0499 | 0.1248 | 0.1248 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0499 | 0.1248 | 0.1248 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.3134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3134 | 1 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0499 | 0.1248 | 0.5 |
Brugia malayi | FXNA | 0.0499 | 0.1248 | 0.1248 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0499 | 0.1248 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0499 | 0.1248 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0499 | 0.1248 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.2 nM | Inhibition of human FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.