Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2677 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.0388 | 0.0388 |
Mycobacterium tuberculosis | Conserved protein | 0.0426 | 0.1528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0388 | 0.0388 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0426 | 0.1528 | 0.1528 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0426 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Schistosoma mansoni | amidase | 0.0123 | 0.0388 | 0.0388 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0426 | 0.1528 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2677 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0426 | 0.1528 | 0.1528 |
Mycobacterium ulcerans | hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0426 | 0.1528 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Brugia malayi | amidase | 0.0123 | 0.0388 | 0.0388 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2677 | 1 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2677 | 1 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0426 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2677 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0426 | 0.1528 | 0.1528 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0426 | 0.1528 | 0.5 |
Onchocerca volvulus | 0.0426 | 0.1528 | 0.1528 | |
Brugia malayi | leucyl aminopeptidase | 0.0426 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0426 | 0.1528 | 0.1528 |
Leishmania major | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Brugia malayi | FXNA | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0426 | 0.1528 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0426 | 0.1528 | 0.1528 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0426 | 0.1528 | 0.1528 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0426 | 0.1528 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Toxoplasma gondii | hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Brugia malayi | nicalin | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 911 nM | Inhibition of human FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.