Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0426 | 0.1528 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Brugia malayi | nicalin | 0.0426 | 0.1528 | 0.1528 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0426 | 0.1528 | 0.1528 |
Leishmania major | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Brugia malayi | leucyl aminopeptidase | 0.0426 | 0.1528 | 0.1528 |
Brugia malayi | FXNA | 0.0426 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0426 | 0.1528 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0426 | 0.1528 | 0.1528 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2677 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2677 | 1 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0426 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.1528 | 0.1528 |
Onchocerca volvulus | 0.0426 | 0.1528 | 0.1528 | |
Leishmania major | hypothetical protein, conserved | 0.0426 | 0.1528 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.0388 | 0.0388 |
Mycobacterium tuberculosis | Conserved protein | 0.0426 | 0.1528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2677 | 1 | 1 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0426 | 0.1528 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Schistosoma mansoni | amidase | 0.0123 | 0.0388 | 0.0388 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0426 | 0.1528 | 0.1528 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0426 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0388 | 0.0388 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2677 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0426 | 0.1528 | 0.1528 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0426 | 0.1528 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0426 | 0.1528 | 0.1528 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2677 | 1 | 1 |
Brugia malayi | amidase | 0.0123 | 0.0388 | 0.0388 |
Mycobacterium ulcerans | hypothetical protein | 0.0426 | 0.1528 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0426 | 0.1528 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0426 | 0.1528 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0388 | 0.0388 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 207 nM | Inhibition of human FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.