TDR Targets

Basic information

Technical information

TDR Targets ID: 185719
Name: 2-[3-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyp ropanoic acid
MW: 326.3 | Formula: C18H14O6
H donors: 2 H acceptors: 4 LogP: 2.79 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(Oc1ccc2c(c1)occ(c2=O)c1ccc(cc1)O)C
InChi: 1S/C18H14O6/c1-10(18(21)22)24-13-6-7-14-16(8-13)23-9-15(17(14)20)11-2-4-12(19)5-3-11/h2-10,19H,1H3,(H,21,22)
InChiKey: VVOLYJNOTQWXLG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[3-(4-hydroxyphenyl)-4-oxo-chromen-7-yl]oxypropanoic acid
2-[[3-(4-hydroxyphenyl)-4-oxo-7-chromenyl]oxy]propanoic acid
2-[3-(4-hydroxyphenyl)-4-keto-chromen-7-yl]oxypropionic acid
99007-87-1
2-((3-(4-Hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl)oxy)propanoic acid
7-(1-Hydroxycarbonylethyl)oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Propanoic acid, 2-((3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl)oxy)-

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 2 family (mitochondrial)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2	aldehyde dehydrogenase 2 family (mitochondrial)	517 aa	490 aa	31.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.1455	0.5867	0.331
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1455	0.5867	0.331
Echinococcus granulosus	kinase suppressor of Ras 1	0.0973	0.3822	0.3822
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0973	0.3822	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0973	0.3822	0.3822
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1455	0.5867	0.5867
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1455	0.5867	0.331
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	SH2 motif	0.1455	0.5867	0.5867
Echinococcus granulosus	SH2 motif	0.1455	0.5867	0.5867
Brugia malayi	Protein kinase domain containing protein	0.2429	1	1
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2429	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Giardia lamblia	Protein 21.1	0.0973	0.3822	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1455	0.5867	0.331
Brugia malayi	Variant SH3 domain containing protein	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	SHC transforming protein 3	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Onchocerca volvulus		0.2429	1	1
Trichomonas vaginalis	TK family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Schistosoma mansoni	hypothetical protein	0.1455	0.5867	0.5867
Brugia malayi	Sex muscle abnormal protein 5	0.1455	0.5867	0.331
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2429	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0973	0.3822	0.3822
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2429	1	1
Onchocerca volvulus		0.2429	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2429	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1455	0.5867	0.5867
Schistosoma mansoni	shc transforming protein	0.1455	0.5867	0.5867
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0973	0.3822	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Entamoeba histolytica	SH2 domain containing protein	0.1455	0.5867	0.331
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2429	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2429	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1455	0.5867	0.331
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2429	1	1
Entamoeba histolytica	protein kinase, putative	0.1455	0.5867	0.331
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1455	0.5867	0.5867
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	SH2 domain-containing protein	0.1455	0.5867	0.331
Echinococcus granulosus	integrin linked protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Brugia malayi	Tensin	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.2429	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0973	0.3822	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2429	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2429	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1455	0.5867	0.5867
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Brugia malayi	RhoGAP domain containing protein	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0973	0.3822	0.3822
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1455	0.5867	0.331
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2429	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2429	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0973	0.3822	0.3822
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1455	0.5867	0.331
Echinococcus granulosus	protein tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	expressed conserved protein	0.1455	0.5867	0.5867
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0973	0.3822	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1455	0.5867	0.5867
Onchocerca volvulus		0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Onchocerca volvulus		0.2429	1	1
Echinococcus multilocularis	protein tyrosine kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine kinase	0.2429	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1455	0.5867	0.5867
Schistosoma mansoni	vav2	0.1455	0.5867	0.5867
Plasmodium falciparum	tyrosine kinase-like protein	0.0973	0.3822	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.1455	0.5867	0.5867
Echinococcus multilocularis	heat shock protein 70	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	SH2 motif	0.1455	0.5867	0.5867
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1455	0.5867	0.5867
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0973	0.3822	0.3822
Plasmodium falciparum	protein kinase, putative	0.0973	0.3822	0.5
Schistosoma mansoni	ephrin receptor	0.0973	0.3822	0.3822
Echinococcus multilocularis	tensin	0.1455	0.5867	0.5867
Onchocerca volvulus		0.2429	1	1
Onchocerca volvulus		0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tensin-related	0.1455	0.5867	0.5867
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2429	1	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0973	0.3822	0.3822
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	hypothetical protein	0.1455	0.5867	0.5867
Brugia malayi	Protein kinase domain containing protein	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0973	0.3822	0.3822
Schistosoma mansoni	tensin	0.1455	0.5867	0.5867
Schistosoma mansoni	tyrosine kinase	0.2429	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2429	1	1
Leishmania major	protein kinase, putative	0.0973	0.3822	1
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2429	1	1
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1455	0.5867	0.5867
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2429	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1455	0.5867	0.331
Echinococcus granulosus	tyrosine protein kinase pr2	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tyrosine kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	serine/threonine RGC	0.0973	0.3822	0.3822
Plasmodium falciparum	tyrosine kinase-like protein	0.0973	0.3822	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1455	0.5867	0.5867
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2429	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0973	0.3822	0.3822
Brugia malayi	Protein kinase domain containing protein	0.2429	1	1
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	insulin receptor	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2429	1	1
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2429	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Brugia malayi	SRC-1	0.2429	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0973	0.3822	0.3822
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0973	0.3822	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0973	0.3822	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	hypothetical protein	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0973	0.3822	1
Loa Loa (eye worm)	STAT protein	0.1455	0.5867	0.331
Schistosoma mansoni	adapter molecule crk	0.1455	0.5867	0.5867
Echinococcus granulosus	insulin receptor	0.0973	0.3822	0.3822
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0973	0.3822	0.3822
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1455	0.5867	0.5867
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2429	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1455	0.5867	0.5867
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0973	0.3822	0.5
Schistosoma mansoni	GTPase activating protein	0.1455	0.5867	0.5867
Echinococcus granulosus	tyrosine protein kinase Blk	0.2429	1	1
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1455	0.5867	0.5867
Echinococcus multilocularis	activin receptor type	0.0973	0.3822	0.3822
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus granulosus	N chimaerin	0.1455	0.5867	0.5867
Echinococcus granulosus	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Brugia malayi	protein-tyrosine kinase	0.2429	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	epidermal growth factor receptor	0.0973	0.3822	0.3822
Onchocerca volvulus		0.2429	1	1
Echinococcus granulosus	SH2 motif	0.1455	0.5867	0.5867
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.2429	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.2429	1	1
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0973	0.3822	0.3822
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus multilocularis	tyrosine protein kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Echinococcus multilocularis	tensin	0.1455	0.5867	0.5867
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus granulosus	NCK adaptor protein	0.1455	0.5867	0.5867
Brugia malayi	hypothetical protein	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0973	0.3822	0.3822
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1455	0.5867	0.331
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus granulosus	tyrosine kinase	0.2429	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1455	0.5867	0.5867
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2429	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.1455	0.5867	0.5867
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1455	0.5867	0.331
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Leishmania major	protein kinase, putative	0.0973	0.3822	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine kinase	0.2429	1	1
Echinococcus multilocularis	NCK adaptor protein	0.1455	0.5867	0.5867
Echinococcus granulosus	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Plasmodium falciparum	protein kinase, putative	0.0973	0.3822	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0973	0.3822	0.3822
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1455	0.5867	0.5867
Schistosoma mansoni	growth factor receptor-bound protein	0.1455	0.5867	0.5867
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2429	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0973	0.3822	0.3822
Echinococcus multilocularis	N chimaerin	0.1455	0.5867	0.5867
Giardia lamblia	Kinase, NEK	0.0973	0.3822	0.5
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Loa Loa (eye worm)	TK/ABL protein kinase	0.2429	1	1
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Schistosoma mansoni	suppressor of cytokine signaling	0.1455	0.5867	0.5867
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	activated cdc42 kinase 1	0.0973	0.3822	0.3822
Echinococcus multilocularis	protein kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1455	0.5867	0.5867
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1455	0.5867	0.5867
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1455	0.5867	0.5867
Loa Loa (eye worm)	SH2 domain-containing protein	0.1455	0.5867	0.331
Trypanosoma cruzi	protein kinase, putative	0.0973	0.3822	0.5
Schistosoma mansoni	hypothetical protein	0.0973	0.3822	0.3822
Trypanosoma brucei	protein kinase, putative	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1455	0.5867	0.5867
Loa Loa (eye worm)	TK protein kinase	0.2429	1	1
Schistosoma mansoni	tensin-related	0.1455	0.5867	0.5867
Loa Loa (eye worm)	TK/FER protein kinase	0.2429	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.1455	0.5867	0.5867
Giardia lamblia	Kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0973	0.3822	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Echinococcus multilocularis	SH2 domain containing protein 7	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.1455	0.5867	0.331
Echinococcus multilocularis	tyrosine kinase	0.2429	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0973	0.3822	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0973	0.3822	0.3822
Schistosoma mansoni	ephrin receptor	0.0973	0.3822	0.3822
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0973	0.3822	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	STE family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tensin	0.1455	0.5867	0.5867
Schistosoma mansoni	tyrosine kinase	0.2429	1	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0973	0.3822	0.3822
Onchocerca volvulus		0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Onchocerca volvulus		0.2429	1	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0973	0.3822	0.3822
Plasmodium vivax	protein kinase, putative	0.0973	0.3822	0.5
Leishmania major	hypothetical protein, conserved	0.0973	0.3822	1
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.1455	0.5867	0.5867
Echinococcus multilocularis	epidermal growth factor receptor	0.0973	0.3822	0.3822
Echinococcus multilocularis	c src tyrosine kinase	0.2429	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0973	0.3822	0.3822
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0973	0.3822	0.3822
Schistosoma mansoni	tensin	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Onchocerca volvulus		0.1455	0.5867	0.331
Brugia malayi	SH2 domain containing protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1455	0.5867	0.331
Echinococcus multilocularis	tyrosine protein kinase shark	0.2429	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2429	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1455	0.5867	0.331
Schistosoma mansoni	suppressor of cytokine signaling	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Plasmodium falciparum	protein kinase, putative	0.0973	0.3822	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0973	0.3822	0.3822
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1455	0.5867	0.331
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0973	0.3822	0.3822
Schistosoma mansoni	protein kinase	0.0973	0.3822	0.3822
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Loa Loa (eye worm)	SRC-1	0.2429	1	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0973	0.3822	0.3822
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis	FL cytokine receptor	0.0973	0.3822	0.3822
Echinococcus granulosus	protein kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2429	1	1
Echinococcus granulosus	activin receptor type	0.0973	0.3822	0.3822
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0973	0.3822	0.3822
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Echinococcus granulosus	epidermal growth factor receptor	0.0973	0.3822	0.3822
Brugia malayi	SH2 domain containing protein	0.2429	1	1
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0973	0.3822	0.3822
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Toxoplasma gondii	protein kinase	0.0973	0.3822	1
Brugia malayi	SH2 domain containing protein	0.2429	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1455	0.5867	0.331
Schistosoma mansoni	tensin	0.1455	0.5867	0.5867
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Brugia malayi	Protein kinase domain containing protein	0.2429	1	1
Echinococcus multilocularis	SH2 motif	0.1455	0.5867	0.5867
Echinococcus granulosus	signal transduction protein lnk realted	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Giardia lamblia	Kinase, NEK	0.0973	0.3822	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Onchocerca volvulus		0.1455	0.5867	0.331
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0973	0.3822	0.3822
Echinococcus granulosus	raf serine:threonine protein kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	nck2/grb4	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0973	0.3822	0.3822
Schistosoma mansoni	hypothetical protein	0.1455	0.5867	0.5867
Trichomonas vaginalis	conserved hypothetical protein	0.0973	0.3822	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1455	0.5867	0.5867
Onchocerca volvulus		0.1455	0.5867	0.331
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Trypanosoma cruzi	protein kinase, putative	0.0973	0.3822	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Schistosoma mansoni	growth factor receptor-bound protein	0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1455	0.5867	0.5867
Echinococcus granulosus	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0973	0.3822	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2429	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1455	0.5867	0.331
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	SH2A	0.1455	0.5867	0.5867
Toxoplasma gondii	STE kinase	0.0973	0.3822	1
Schistosoma mansoni	tyrosine kinase	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Schistosoma mansoni	tyrosine kinase	0.0973	0.3822	0.3822
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0973	0.3822	0.3822
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0973	0.3822	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0973	0.3822	0.3822
Schistosoma mansoni	protein tyrosine kinase	0.0973	0.3822	0.3822
Echinococcus multilocularis		0.1455	0.5867	0.5867
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0973	0.3822	0.3822
Echinococcus granulosus	SHC transforming protein 3	0.1455	0.5867	0.5867
Echinococcus granulosus	c src tyrosine kinase	0.2429	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0973	0.3822	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0973	0.3822	0.3822
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1455	0.5867	0.331
Echinococcus multilocularis	tyrosine protein kinase csk	0.0973	0.3822	0.3822
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0973	0.3822	0.3822
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2429	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2429	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.2429	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1455	0.5867	0.331

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.5 uM	Inhibition of hamster liver aldehyde dehydrogenase ALDH-2	ChEMBL.	11563931
IC50 (binding)	= 2.5 uM	Inhibition of hamster liver aldehyde dehydrogenase ALDH-2	ChEMBL.	11563931
NI (binding)		Inhibition of hamster liver mitochondrial monoamine oxidase MAO	ChEMBL.	11563931
NI (binding)	0	Inhibition of hamster liver mitochondrial monoamine oxidase MAO	ChEMBL.	11563931

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL112286

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 185719