Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | para nitrobenzyl esterase | 0.0053 | 0.0026 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Echinococcus multilocularis | acetylcholinesterase | 0.0312 | 0.0424 | 0.4281 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.4919 | 0.7484 | 0.7477 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0053 | 0.0026 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0424 | 0.149 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0096 | 0.0092 | 0.0082 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0346 | 0.0476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0346 | 0.0476 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.001 | 0.0021 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0012 | 0.025 |
Loa Loa (eye worm) | carboxylesterase | 0.0312 | 0.0424 | 0.149 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.0149 | 0.0123 |
Plasmodium vivax | hypothetical protein, conserved | 0.0346 | 0.0476 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0053 | 0.0026 | 0.0227 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.0129 | 0.2543 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0346 | 0.0476 | 0.0451 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0106 | 0.0109 | 0.0099 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0346 | 0.0476 | 0.4822 |
Loa Loa (eye worm) | twinkle helicase | 0.1875 | 0.2818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0096 | 0.0092 | 0.0082 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.0026 | 0.0016 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.6561 | 1 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0346 | 0.0476 | 0.4822 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Leishmania major | UDP-galactopyranose mutase | 0.0346 | 0.0476 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 0.0332 | 0.6973 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0174 | 0.0212 | 0.0739 |
Echinococcus multilocularis | acetylcholinesterase | 0.0312 | 0.0424 | 0.4281 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Schistosoma mansoni | amine oxidase | 0.0346 | 0.0476 | 0.0472 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0346 | 0.0476 | 0.0467 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0346 | 0.0476 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0053 | 0.0026 | 0.0227 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.6561 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0053 | 0.0026 | 0.047 |
Mycobacterium ulcerans | monoamine oxidase | 0.0346 | 0.0476 | 0.0451 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0106 | 0.0109 | 0.0017 |
Schistosoma mansoni | Replicative DNA helicase | 0.6561 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0312 | 0.0424 | 0.4281 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.4919 | 0.7484 | 0.7477 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.0424 | 0.8879 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.6561 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0133 | 0.0149 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0042 | 0.001 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0053 | 0.0026 | 0.0022 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.4572 | 0.6953 | 0.695 |
Echinococcus granulosus | acetylcholinesterase | 0.0312 | 0.0424 | 0.8879 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.0026 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0346 | 0.0476 | 0.0472 |
Brugia malayi | Pre-SET motif family protein | 0.0174 | 0.0212 | 0.4401 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0106 | 0.0109 | 0.0099 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0053 | 0.0026 | 0.047 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.001 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0053 | 0.0026 | 0.0016 |
Mycobacterium ulcerans | oxidoreductase | 0.0346 | 0.0476 | 0.0451 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0042 | 0.001 | 0.0059 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Mycobacterium tuberculosis | Probable reductase | 0.0096 | 0.0092 | 0.0082 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.001 | 0.0042 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.0026 | 0.0016 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0346 | 0.0476 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0312 | 0.0424 | 0.042 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.0026 | 0.0079 |
Schistosoma mansoni | amine oxidase | 0.0346 | 0.0476 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0096 | 0.0092 | 0.0082 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.0129 | 0.2699 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0346 | 0.0476 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0026 | 0.047 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.0424 | 0.8879 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0119 | 0.0129 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0252 | 0.0332 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0053 | 0.0026 | 0.047 |
Brugia malayi | SWIRM domain containing protein | 0.0346 | 0.0476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0677 | 0.0984 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0198 | 0.0249 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0346 | 0.0476 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.001 | 0.0122 |
Mycobacterium ulcerans | dehydrogenase | 0.0346 | 0.0476 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0424 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0346 | 0.0476 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.6561 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.001 | 0.03 |
Onchocerca volvulus | 0.0198 | 0.0249 | 0.4943 | |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0096 | 0.0092 | 0.0082 |
Echinococcus granulosus | carboxylesterase 5A | 0.0312 | 0.0424 | 0.8879 |
Echinococcus multilocularis | 0.0346 | 0.0476 | 0.4822 | |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0346 | 0.0476 | 0.0472 |
Plasmodium vivax | hypothetical protein, conserved | 0.0346 | 0.0476 | 1 |
Onchocerca volvulus | 0.0346 | 0.0476 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0106 | 0.0109 | 0.0099 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0346 | 0.0476 | 1 |
Brugia malayi | glutathione reductase | 0.0042 | 0.001 | 0.0122 |
Schistosoma mansoni | gliotactin | 0.0053 | 0.0026 | 0.0022 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.6561 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0096 | 0.0092 | 0.0082 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.001 | 0.0021 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0346 | 0.0476 | 0.0388 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0252 | 0.0332 | 0.6908 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 0.0332 | 0.6973 |
Echinococcus granulosus | acetylcholinesterase | 0.0312 | 0.0424 | 0.8879 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0346 | 0.0476 | 0.0467 |
Echinococcus multilocularis | neuroligin | 0.0053 | 0.0026 | 0.0227 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0312 | 0.0424 | 0.149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.