Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0312 | 0.0424 | 0.149 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.0149 | 0.0123 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0012 | 0.025 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.001 | 0.0021 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0346 | 0.0476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0096 | 0.0092 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0424 | 0.149 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0053 | 0.0026 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.4919 | 0.7484 | 0.7477 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Echinococcus multilocularis | acetylcholinesterase | 0.0312 | 0.0424 | 0.4281 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0053 | 0.0026 | 0.047 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.0026 | 0.0016 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0096 | 0.0092 | 0.0082 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Loa Loa (eye worm) | twinkle helicase | 0.1875 | 0.2818 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0106 | 0.0109 | 0.0099 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0346 | 0.0476 | 0.4822 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0346 | 0.0476 | 0.0451 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.0129 | 0.2543 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0053 | 0.0026 | 0.0227 |
Plasmodium vivax | hypothetical protein, conserved | 0.0346 | 0.0476 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0346 | 0.0476 | 0.0451 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0106 | 0.0109 | 0.0017 |
Echinococcus granulosus | neuroligin | 0.0053 | 0.0026 | 0.047 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.6561 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0053 | 0.0026 | 0.0227 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0346 | 0.0476 | 0.0467 |
Schistosoma mansoni | amine oxidase | 0.0346 | 0.0476 | 0.0472 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0174 | 0.0212 | 0.0739 |
Echinococcus multilocularis | acetylcholinesterase | 0.0312 | 0.0424 | 0.4281 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 0.0332 | 0.6973 |
Leishmania major | UDP-galactopyranose mutase | 0.0346 | 0.0476 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0346 | 0.0476 | 0.4822 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.6561 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0346 | 0.0476 | 0.0472 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0346 | 0.0476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Echinococcus granulosus | acetylcholinesterase | 0.0312 | 0.0424 | 0.8879 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.0026 | 0.0079 |
Schistosoma mansoni | acetylcholinesterase | 0.0053 | 0.0026 | 0.0022 |
Brugia malayi | hypothetical protein | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.4572 | 0.6953 | 0.695 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0042 | 0.001 | 0.0122 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0133 | 0.0149 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.6561 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.0424 | 0.8879 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0312 | 0.0424 | 0.4281 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.4919 | 0.7484 | 0.7477 |
Schistosoma mansoni | Replicative DNA helicase | 0.6561 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0312 | 0.0424 | 0.042 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.001 | 0.0042 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.0026 | 0.0016 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Mycobacterium tuberculosis | Probable reductase | 0.0096 | 0.0092 | 0.0082 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0026 | 0.047 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0042 | 0.001 | 0.0059 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0053 | 0.0026 | 0.0016 |
Mycobacterium ulcerans | oxidoreductase | 0.0346 | 0.0476 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.001 | 0.0209 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0053 | 0.0026 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0106 | 0.0109 | 0.0099 |
Brugia malayi | Pre-SET motif family protein | 0.0174 | 0.0212 | 0.4401 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0119 | 0.0129 | 0.3871 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.0424 | 0.8879 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0026 | 0.047 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.0129 | 0.2699 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0346 | 0.0476 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0096 | 0.0092 | 0.0082 |
Schistosoma mansoni | amine oxidase | 0.0346 | 0.0476 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.0026 | 0.0079 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0053 | 0.0026 | 0.0022 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0346 | 0.0476 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0346 | 0.0476 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0346 | 0.0476 | 0.0472 |
Onchocerca volvulus | 0.0346 | 0.0476 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0106 | 0.0109 | 0.0099 |
Echinococcus multilocularis | 0.0346 | 0.0476 | 0.4822 | |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0096 | 0.0092 | 0.0082 |
Onchocerca volvulus | 0.0198 | 0.0249 | 0.4943 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0312 | 0.0424 | 0.8879 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.001 | 0.03 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0346 | 0.0476 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.6561 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0424 | 0.149 |
Mycobacterium ulcerans | dehydrogenase | 0.0346 | 0.0476 | 0.0451 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0346 | 0.0476 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.001 | 0.0122 |
Brugia malayi | SWIRM domain containing protein | 0.0346 | 0.0476 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0677 | 0.0984 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.0476 | 0.1678 |
Trichomonas vaginalis | set domain proteins, putative | 0.0198 | 0.0249 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0053 | 0.0026 | 0.047 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0252 | 0.0332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0026 | 0.0079 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0312 | 0.0424 | 0.149 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0346 | 0.0476 | 0.0467 |
Echinococcus multilocularis | neuroligin | 0.0053 | 0.0026 | 0.0227 |
Echinococcus granulosus | acetylcholinesterase | 0.0312 | 0.0424 | 0.8879 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 0.0332 | 0.6973 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0346 | 0.0476 | 0.0388 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0252 | 0.0332 | 0.6908 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.001 | 0.0021 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.6561 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0096 | 0.0092 | 0.0082 |
Schistosoma mansoni | gliotactin | 0.0053 | 0.0026 | 0.0022 |
Brugia malayi | glutathione reductase | 0.0042 | 0.001 | 0.0122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.