Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Bradykinin B2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Bradykinin B2 receptor | 372 aa | 313 aa | 19.2 % |
Onchocerca volvulus | Bradykinin B2 receptor | 372 aa | 383 aa | 20.9 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Bradykinin B2 receptor | 372 aa | 355 aa | 21.4 % |
Brugia malayi | putative neuropeptide receptor NPR1 | Bradykinin B2 receptor | 372 aa | 312 aa | 24.0 % |
Loa Loa (eye worm) | hypothetical protein | Bradykinin B2 receptor | 372 aa | 311 aa | 23.5 % |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Bradykinin B2 receptor | 372 aa | 326 aa | 22.7 % |
Echinococcus multilocularis | neuropeptide receptor | Bradykinin B2 receptor | 372 aa | 305 aa | 24.6 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Bradykinin B2 receptor | 372 aa | 339 aa | 23.9 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Bradykinin B2 receptor | 372 aa | 337 aa | 25.5 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Bradykinin B2 receptor | 372 aa | 335 aa | 22.7 % |
Schistosoma japonicum | Rhodopsin, putative | Bradykinin B2 receptor | 372 aa | 323 aa | 20.4 % |
Onchocerca volvulus | Bradykinin B2 receptor | 372 aa | 305 aa | 24.3 % | |
Schistosoma mansoni | adenoreceptor | Bradykinin B2 receptor | 372 aa | 361 aa | 21.1 % |
Echinococcus granulosus | neuropeptide receptor | Bradykinin B2 receptor | 372 aa | 338 aa | 24.0 % |
Onchocerca volvulus | Bradykinin B2 receptor | 372 aa | 323 aa | 20.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.179 | 1 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | WD40 repeat protein | 0.179 | 1 | 1 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0228 | 0.0639 | 0.058 |
Echinococcus granulosus | protein will die slowly | 0.179 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0063 | 0.0063 |
Toxoplasma gondii | SPRY domain-containing protein | 0.0122 | 0 | 0.5 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0228 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0132 | 0.0063 | 0.0063 |
Echinococcus multilocularis | wd40 repeat | 0.0228 | 0.0639 | 0.058 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0639 | 0.0639 |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0228 | 0.0639 | 0.058 |
Plasmodium falciparum | SPRY domain, putative | 0.0132 | 0.0063 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0132 | 0.0063 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.179 | 1 | 1 |
Trichomonas vaginalis | WD repeat domain, putative | 0.179 | 1 | 1 |
Echinococcus multilocularis | protein will die slowly | 0.179 | 1 | 1 |
Echinococcus granulosus | wd40 repeat | 0.0228 | 0.0639 | 0.058 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.059 uM | Inhibition of BK-induced (4x10E-8M) contraction of isolated guinea pig ileum (GPI) | ChEMBL. | 10091678 |
EC50 (functional) | = 0.059 uM | Inhibition of BK-induced (4x10E-8M) contraction of isolated guinea pig ileum (GPI) | ChEMBL. | 10091678 |
IC50 (binding) | = 5.2 nM | Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | ChEMBL. | 10091678 |
IC50 (binding) | = 5.2 nM | Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | ChEMBL. | 10091678 |
Inhibition (functional) | = 95 % | % Inhibition of BK-induced (4x10E-8M) contraction of rabbit jugular vein (RJV) at 10E-5 M concentration | ChEMBL. | 10091678 |
Inhibition (functional) | = 95 % | % Inhibition of BK-induced (4x10E-8M) contraction of rabbit jugular vein (RJV) at 10E-5 M concentration | ChEMBL. | 10091678 |
Ki (binding) | = 0.6 nM | Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | ChEMBL. | 10091678 |
Ki (binding) | = 0.6 nM | Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | ChEMBL. | 10091678 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.