Detailed information for compound 1881234

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 378.507 | Formula: C24H30N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.64 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCCc2c1c(cc(c2)n1cc(c2c1CC(C)(C)CC2=O)C)C(C)(C)C
  • InChi: 1S/C24H30N2O2/c1-14-13-26(18-11-24(5,6)12-19(27)20(14)18)16-9-15-7-8-25-22(28)21(15)17(10-16)23(2,3)4/h9-10,13H,7-8,11-12H2,1-6H3,(H,25,28)
  • InChiKey: FLANSLWVOMGKFX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 Starlite/ChEMBL References
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL References
Homo sapiens heat shock protein 90kDa beta (Grp94), member 1 Starlite/ChEMBL References
Homo sapiens TNF receptor-associated protein 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein, putative Get druggable targets OG5_129844 All targets in OG5_129844
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_129844 All targets in OG5_129844
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09488 TNF receptor-associated protein 1, putative Get druggable targets OG5_129844 All targets in OG5_129844
Plasmodium vivax heat shock protein 90, putative Get druggable targets OG5_129844 All targets in OG5_129844
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 75, putative Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii Hsp90-related Get druggable targets OG5_129844 All targets in OG5_129844
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein, mitochondrial precursor, putative Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_129844 All targets in OG5_129844
Trypanosoma brucei heat shock protein 84, putative Get druggable targets OG5_129844 All targets in OG5_129844
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 75 kDa mitochondrial Get druggable targets OG5_129844 All targets in OG5_129844
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein, putative Get druggable targets OG5_129844 All targets in OG5_129844
Brugia malayi Hsp90 protein Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis heat shock protein 75, putative Get druggable targets OG5_129844 All targets in OG5_129844
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 75, putative Get druggable targets OG5_129844 All targets in OG5_129844
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 75 Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania braziliensis heat shock protein, putative Get druggable targets OG5_129844 All targets in OG5_129844
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein, putative Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein, mitochondrial precursor, putative,TNFR-associated protein 1 Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania major heat shock protein, putative Get druggable targets OG5_129844 All targets in OG5_129844
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_129844 All targets in OG5_129844
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein, putative Get druggable targets OG5_129844 All targets in OG5_129844
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 90, putative TNF receptor-associated protein 1 651 aa 716 aa 31.3 %
Plasmodium falciparum heat shock protein 90, putative heat shock protein 90kDa beta (Grp94), member 1 803 aa 727 aa 37.0 %
Plasmodium falciparum heat shock protein 90, putative heat shock protein 90kDa alpha (cytosolic), class B member 1 724 aa 725 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0134 1 1
Echinococcus granulosus heat shock protein 90 0.0134 1 1
Schistosoma mansoni heat shock protein 0.0134 1 1
Echinococcus multilocularis heat shock protein 90 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Trypanosoma cruzi heat shock protein, putative 0.0123 0.8393 0.8264
Mycobacterium ulcerans heat shock protein 90 0.0114 0.7211 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.011 0.655 0.6272
Trichomonas vaginalis heat shock protein, putative 0.0134 1 1
Loa Loa (eye worm) endoplasmin 0.0134 1 1
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Plasmodium vivax endoplasmin, putative 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0114 0.7211 0.5
Leishmania major heat shock protein 83-1 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Schistosoma mansoni endoplasmin 0.0134 1 1
Trichomonas vaginalis endoplasmin, putative 0.0088 0.345 0.345
Trypanosoma brucei heat shock protein 90, putative 0.0134 1 1
Trypanosoma brucei heat shock protein 90, putative 0.0134 1 1
Echinococcus granulosus heat shock protein 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Plasmodium vivax heat shock protein 90, putative 0.0123 0.8393 0.8279
Echinococcus granulosus endoplasmin 0.0114 0.7211 0.1916
Trichomonas vaginalis heat shock protein, putative 0.011 0.655 0.655
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0114 0.7211 0.5
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0123 0.8393 0.5
Schistosoma mansoni heat shock protein 0.0134 1 1
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0134 1 1
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0134 1 1
Plasmodium vivax heat shock protein 86, putative 0.0134 1 1
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0114 0.7211 0.5
Leishmania major heat shock protein 83-1 0.0134 1 1
Trichomonas vaginalis heat shock protein, putative 0.0088 0.345 0.345
Leishmania major heat shock protein 83-1 0.0134 1 1
Leishmania major heat shock protein, putative 0.0123 0.8393 0.4239
Toxoplasma gondii heat shock protein HSP90 0.0134 1 1
Plasmodium falciparum heat shock protein 90 0.0134 1 1
Plasmodium falciparum endoplasmin, putative 0.0088 0.345 0.2987
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0123 0.8393 0.5343
Trypanosoma cruzi heat shock protein 85, putative 0.011 0.655 0.6272
Trypanosoma brucei Heat shock protein 83, putative 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Loa Loa (eye worm) heat shock protein 90 0.0134 1 1
Entamoeba histolytica heat shock protein 90, putative 0.0134 1 1
Toxoplasma gondii heat shock protein 90, putative 0.0134 1 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0134 1 1
Giardia lamblia Grp94/Hsp90 0.0114 0.7211 0.1916
Echinococcus multilocularis endoplasmin 0.0114 0.7211 0.1916
Trypanosoma brucei heat shock protein, putative 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Entamoeba histolytica heat shock protein 90, putative 0.0134 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Trichomonas vaginalis heat shock protein, putative 0.0114 0.7211 0.7211
Leishmania major heat shock protein 83-1 0.0134 1 1
Echinococcus multilocularis heat shock protein 0.0134 1 1
Leishmania major heat shock protein 83-1 0.0134 1 1
Toxoplasma gondii heat shock protein 75, putative 0.0123 0.8393 0.8279
Schistosoma mansoni endoplasmin 0.0134 1 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0123 0.8393 0.5343
Leishmania major heat shock protein 83-1 0.0134 1 1
Trichomonas vaginalis heat shock protein, putative 0.0114 0.7211 0.7211
Plasmodium falciparum heat shock protein 90, putative 0.0118 0.7732 0.7571
Treponema pallidum heat shock protein 90 0.0114 0.7211 0.5
Brugia malayi heat shock protein 90 0.0134 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.7 uM Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysis ChEMBL. 24673104
Ki (binding) = 0.14 uM Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assay ChEMBL. 24673104
Ki (binding) = 0.18 uM Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assay ChEMBL. 24673104
Ki (binding) > 10 uM Displacement of FITC-geldanamycin from recombinant GRP94 (unknown origin) after 2 hrs by fluorescence polarization assay ChEMBL. 24673104
Ki (binding) > 10 uM Displacement of FITC-geldanamycin from recombinant TRAP1 (unknown origin) after 2 hrs by fluorescence polarization assay ChEMBL. 24673104

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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