Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Starlite/ChEMBL | References |
Rattus norvegicus | Steroid 5-alpha-reductase 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Steroid 5-alpha-reductase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0121 | 0.0084 | 0.032 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0566 | 0.098 | 0.3747 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.008 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0171 | 0.0183 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0171 | 0.0183 | 0.111 |
Mycobacterium ulcerans | hypothetical protein | 0.0566 | 0.098 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.3666 | 0.7225 | 1 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0121 | 0.0084 | 0.032 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1378 | 0.2615 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0566 | 0.098 | 0.3747 |
Treponema pallidum | DNA polymerase I (polA) | 0.0171 | 0.0183 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1378 | 0.2615 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1378 | 0.2615 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1378 | 0.2615 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1378 | 0.2615 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1378 | 0.2615 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0566 | 0.098 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.008 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0171 | 0.0183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0566 | 0.098 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0566 | 0.098 | 0.3747 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0171 | 0.0183 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0566 | 0.098 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0566 | 0.098 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0566 | 0.098 | 0.1356 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0566 | 0.098 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0171 | 0.0183 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0566 | 0.098 | 0.3541 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0566 | 0.098 | 0.3747 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.008 | 0 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.008 | 0 | 0.5 |
Plasmodium falciparum | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0121 | 0.0084 | 0.032 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1378 | 0.2615 | 1 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0121 | 0.0084 | 0.032 |
Plasmodium vivax | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0121 | 0.0084 | 0.032 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1378 | 0.2615 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.37 uM | Inhibition of Steroid 5-alpha-reductase type 2 of rat ventral prostate (RVP) | ChEMBL. | 12139451 |
IC50 (binding) | = 0.37 uM | Inhibition of Steroid 5-alpha-reductase type 2 of rat ventral prostate (RVP) | ChEMBL. | 12139451 |
IC50 (binding) | = 0.53 uM | Inhibition of Steroid 5-alpha-reductase type 2 from human benign prostatic hyperplasia (BPH) tissue | ChEMBL. | 12139451 |
IC50 (binding) | = 0.53 uM | Inhibition of Steroid 5-alpha-reductase type 2 from human benign prostatic hyperplasia (BPH) tissue | ChEMBL. | 12139451 |
IC50 (binding) | = 3.4 uM | Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP) | ChEMBL. | 12139451 |
IC50 (binding) | = 3.4 uM | Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP) | ChEMBL. | 12139451 |
Inhibition (binding) | = 26 % | Inhibition of Steroid 5-alpha-reductase type I of human DU 145 prostatic tumor cell line, at 10 microM | ChEMBL. | 12139451 |
Inhibition (binding) | = 26 % | Inhibition of Steroid 5-alpha-reductase type I of human DU 145 prostatic tumor cell line, at 10 microM | ChEMBL. | 12139451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.