Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | membrane metallo-endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | alanyl (membrane) aminopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.7118 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7118 | 0.8341 |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.7118 | 0.7118 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4172 | 0.4889 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7118 | 0.8341 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8533 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.7118 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7118 | 0.8341 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.1525 | 0.2142 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4368 | 0.5119 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4368 | 0.5119 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4172 | 0.4889 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0058 | 0.1525 | 0.2142 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4368 | 0.5119 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7295 | 0.8549 |
Onchocerca volvulus | 0.0056 | 0.1422 | 0.1422 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1422 | 0.1666 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4368 | 0.5119 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.7118 | 0.7118 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4368 | 0.5119 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.7118 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.4172 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5828 | 0.683 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4368 | 0.5119 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4172 | 0.4889 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.7118 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.1525 | 0.2142 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0058 | 0.1525 | 0.2142 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.7118 | 0.7118 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.4172 | 0.4889 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0058 | 0.1525 | 0.2142 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.7118 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4172 | 0.4889 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.7118 | 0.7118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11 nM | Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | ChEMBL. | 24927250 |
Ki (binding) | = 11 nM | Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorometry | ChEMBL. | 26241877 |
Ki (binding) | > 10000 nM | Inhibition of recombinant human Neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorometry | ChEMBL. | 26241877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.