TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.895 | Formula: C23H24ClNO2
H donors: 0 H acceptors: 1 LogP: 5.41 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC(=CCN1CCC2(CC1)c1ccccc1Oc1c(C2=O)cc(Cl)cc1)C
InChi: 1S/C23H24ClNO2/c1-16(2)9-12-25-13-10-23(11-14-25)19-5-3-4-6-21(19)27-20-8-7-17(24)15-18(20)22(23)26/h3-9,15H,10-14H2,1-2H3
InChiKey: OBOPHDQLQCBFFO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0171	0.2261
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0484	0.0404
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.2551	0.7709
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0589	0.051
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0493	0.8263
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0961
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0171	0.0239
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0469	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0484	0.1098
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.395
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0171	0.1724
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0283	0.0621
Schistosoma mansoni	hypothetical protein	0.0034	0.0512	0.1176
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0115	0.0099
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0115	0.14
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0878	0.2179
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0484	0.0404
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0115	0.0087
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1098
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.2059	0.6147
Schistosoma mansoni	hypothetical protein	0.0034	0.0512	0.1176
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0493	0.1973
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0171	0.0731
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0493	0.8107
Leishmania major	glucose transporter, lmgt3	0.0034	0.0493	0.344
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0484	0.1359
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0493	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0512	0.1447
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0512	0.1176
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.2059	0.5419
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0333	0.0895
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.1404	0.411
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0493	0.1973
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.1275	0.3268
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0484	0.0404
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1098
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0115	0.0087
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0469	1
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0512	0.1176
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	0.4243
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0171	0.1724
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0154	0.1383
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0512	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0469	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1404	0.4186
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0115	0.0032
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.0115	0.0266
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.1275	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0484	0.0617
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.013
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0171	0.0397
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.013
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0115	0.0087
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0108	0.216	0.5698
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0171	0.0271
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0493	0.1973
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0115	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0493	0.8263
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.1275	0.3268
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0283	0.0201
Schistosoma mansoni	patched 1	0.0045	0.0737	0.1794
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0171	0.0419
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.2059	0.5419
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0493	0.8263
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0283	0.0308
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.4449
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Echinococcus granulosus	dna polymerase eta	0.0019	0.0171	0.0239
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0737	0.1794
Schistosoma mansoni	hypothetical protein	0.0108	0.216	0.5698
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.054	0.1251
Entamoeba histolytica	hypothetical protein	0.0036	0.054	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0484	0.0404
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0171	0.0419
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0484	0.1359
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0512	0.1176
Leishmania major	glucose transporter, lmgt1	0.0034	0.0493	0.344
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0589	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0069	0.1275	1
Plasmodium vivax	hexose transporter	0.0108	0.216	0.2094
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0493	0.1973
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0493	0.344
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0493	0.8263
Echinococcus multilocularis	geminin	0.0179	0.3728	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.2059	1
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0493	0.8107
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0115	0.14
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0171	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0115	0.0628
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0469	0.1057
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0171	0.0239
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.2173	0.6547
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.2173	0.6501
Brugia malayi	Cam kinase protein 1	0.0033	0.0484	0.1245
Echinococcus multilocularis	General substrate transporter	0.0093	0.1821	0.4766
Echinococcus granulosus	GPCR family 2	0.0034	0.0512	0.1176
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.1275	0.3268
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0493	0.1973
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0115	0.0266
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0484	0.1927
Echinococcus multilocularis	Niemann Pick C1 protein	0.0148	0.3052	0.8145
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0484	0.0617
Schistosoma mansoni	hypothetical protein	0.0034	0.0512	0.1176
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0283	0.0548
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0171	0.0239
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0737	0.1794
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.0657
Schistosoma mansoni	hypothetical protein	0.0043	0.0702	0.1695
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0171	0.2406
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	0.1658
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0171	0.2406
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0171	0.0239
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0493	0.1973
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0737	0.1794
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0737	0.2137
Echinococcus granulosus	Niemann Pick C1 protein	0.0148	0.3052	0.8145
Entamoeba histolytica	hypothetical protein	0.0024	0.0283	0.0596
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0283	0.0548
Plasmodium falciparum	protein kinase 7	0.0306	0.6571	0.6542
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0175	0.3649	0.3595
Echinococcus granulosus	expressed conserved protein	0.0098	0.1919	0.5034
Toxoplasma gondii	aldehyde dehydrogenase	0.0069	0.1275	0.1836
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2059	0.6197
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0115	0.0049
Echinococcus multilocularis	protein patched	0.0045	0.0737	0.1794
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.2095	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2173	0.6547
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0175	0.3649	0.5495
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.2223
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0115	0.0032
Toxoplasma gondii	facilitative glucose transporter GT1	0.0108	0.216	0.3201
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0115	0.0049
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0438	0.0972
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Loa Loa (eye worm)	sugar transporter	0.0108	0.216	0.6509
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0171	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Trypanosoma brucei	unspecified product	0.0019	0.0171	0.2406
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0961	0.2824
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3297	1
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.054	0.1251
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.0657
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0469	0.1199
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0548
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0512	0.1176
Brugia malayi	CHE-14 protein	0.0045	0.0737	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0469	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0283	0.0743
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.1275	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0548
Echinococcus multilocularis	expressed conserved protein	0.0098	0.1919	0.5034
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0484	0.1098
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.0657
Schistosoma mansoni	hypothetical protein	0.0075	0.1404	0.3623
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Leishmania major	glucose transporter, lmgt2	0.0034	0.0493	0.344
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.1676
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0171	0.1724
Schistosoma mansoni	glucose transport protein	0.0108	0.216	0.5698
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0171	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Brugia malayi	hypothetical protein	0.0036	0.054	0.1419
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0283	0.0201
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	0.4243
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0469	0.1057
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0438	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Schistosoma mansoni	hypothetical protein	0.0034	0.0512	0.1176
Entamoeba histolytica	hypothetical protein	0.0036	0.054	0.1954
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0171	0.1724
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0484	0.8091
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.0657
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Schistosoma mansoni	hypothetical protein	0.0036	0.054	0.1251
Entamoeba histolytica	hypothetical protein	0.0036	0.054	0.1954
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0084	0.0824
Entamoeba histolytica	hypothetical protein	0.0036	0.054	0.1954
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0589	0.0779
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.1275	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0171	0.0397
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0484	0.0404
Schistosoma mansoni	hypothetical protein	0.0043	0.0702	0.1695
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0484	0.0404
Brugia malayi	MH2 domain containing protein	0.0126	0.2551	0.7679
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0469	0.1199
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0469	0.1579
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0283	0.3046
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0171	0.2406
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0484	0.0404
Schistosoma mansoni	hypothetical protein	0.0179	0.3728	1
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0171	0.0239
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0171	0.0239
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0115	0.0087
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0115	0.0087
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0171	0.0731
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0171	0.0239
Onchocerca volvulus		0.0159	0.3297	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0493	0.8263
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0493	0.8107
Schistosoma mansoni	glucose transport protein	0.0108	0.216	0.5698
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0217	0.0641
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0171	0.134
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0484	0.0404
Plasmodium vivax	CDK-related protein kinase 6, putative	0.046	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0171	0.0731
Brugia malayi	hypothetical protein	0.0159	0.3297	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.0171	0.0731
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0283	0.5182
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0069	0.1275	1
Schistosoma mansoni	glucose transport protein	0.0108	0.216	0.5698
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0469	0.1057
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.054	0.1251
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0115	0.0087
Brugia malayi	Sugar transporter family protein	0.0108	0.216	0.6463
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0084	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0512	0.1176
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.1275	0.3268
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0084	0.0824
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0512	0.1334
Plasmodium falciparum	hexose transporter	0.0108	0.216	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.2551	0.7709
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.013
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.013
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0171	0.0271
Schistosoma mansoni	hypothetical protein	0.0043	0.0702	0.1695
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0484	0.0617
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0115	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0737	0.2137
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0469	0.1313
Echinococcus granulosus	geminin	0.0179	0.3728	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Echinococcus granulosus	General substrate transporter	0.0093	0.1821	0.4766
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0589	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0171	0.2406
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0115	0.0227
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0484	0.0404
Schistosoma mansoni	hypothetical protein	0.0043	0.0702	0.1695
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.216	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1098
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0171	0.2406
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0283	1
Toxoplasma gondii	protein kinase, putative	0.0306	0.6571	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0589	0.051
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Schistosoma mansoni	hypothetical protein	0.0179	0.3728	1
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0737	0.3148
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0512	0.1447
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0115	0.0628
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.2223
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0484	0.1359
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0484	0.1245
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.5698
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0175	0.3649	0.3595
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1098
Trypanosoma cruzi	hexose transporter	0.0034	0.0493	0.8107
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0469	0.1855
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8263
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0202	0.0993
Leishmania major	protein kinase, putative	0.0033	0.0484	0.336
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0202	0.0993
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.2173	0.6501
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0171	0.134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3302326

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1903086