Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine proteinase, putative | 0.003 | 0.1012 | 0.5 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.003 | 0.1012 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.5832 | 0.5832 |
Echinococcus multilocularis | cysteine protease | 0.003 | 0.1012 | 0.1012 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.003 | 0.1012 | 0.1012 |
Entamoeba histolytica | cysteine protease, putative | 0.003 | 0.1012 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.5358 | 0.5358 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0058 | 0.293 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0058 | 0.293 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.003 | 0.1012 | 0.1735 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0162 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5832 | 0.5832 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0058 | 0.293 | 1 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.003 | 0.1012 | 0.1012 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0162 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0162 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0058 | 0.293 | 0.2134 |
Echinococcus multilocularis | cathepsin b | 0.0162 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0162 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0162 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0162 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0162 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0058 | 0.293 | 0.293 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.293 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0162 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.5832 | 0.5832 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.293 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1012 | 0.1012 |
Onchocerca volvulus | 0.0101 | 0.5832 | 1 | |
Loa Loa (eye worm) | cathepsin B | 0.0058 | 0.293 | 0.293 |
Onchocerca volvulus | 0.0101 | 0.5832 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1012 | 0.1012 |
Onchocerca volvulus | Cathepsin L homolog | 0.003 | 0.1012 | 0.1735 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Onchocerca volvulus | 0.0101 | 0.5832 | 1 | |
Plasmodium vivax | vivapain-2 | 0.003 | 0.1012 | 0.5 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.003 | 0.1012 | 0.1012 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Loa Loa (eye worm) | ctsf protein | 0.003 | 0.1012 | 0.1012 |
Brugia malayi | cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.003 | 0.1012 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.003 | 0.1012 | 0.1012 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.003 | 0.1012 | 0.1012 |
Plasmodium vivax | vivapain-2 | 0.003 | 0.1012 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0058 | 0.293 | 1 |
Onchocerca volvulus | 0.003 | 0.1012 | 0.1735 | |
Echinococcus granulosus | cathepsin l1 | 0.003 | 0.1012 | 0.1012 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.5832 | 0.5832 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.003 | 0.1012 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.293 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.003 | 0.1012 | 0.1012 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.003 | 0.1012 | 0.1012 |
Echinococcus multilocularis | cysteine protease | 0.003 | 0.1012 | 0.1012 |
Entamoeba histolytica | cysteine proteinase, putative | 0.003 | 0.1012 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.003 | 0.1012 | 0.1735 |
Loa Loa (eye worm) | cysteine protease | 0.003 | 0.1012 | 0.1012 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5832 | 0.5832 |
Loa Loa (eye worm) | fibroinase | 0.003 | 0.1012 | 0.1012 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.003 | 0.1012 | 0.1012 |
Entamoeba histolytica | cysteine proteinase, putative | 0.003 | 0.1012 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 490 nM | Inhibition of biotinylated alpha-bungarotoxin binding to alpha7 nAChR in rat PC12 cells by FACS analysis | ChEMBL. | 24814197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.