Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Treponema pallidum | ATP-dependent nuclease, subunit A | 0.0038 | 0.0176 | 0.999 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0281 | 0.2211 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0161 |
Mycobacterium tuberculosis | Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) | 0.0607 | 0.4687 | 0.4679 |
Giardia lamblia | RNA helicase, putative | 0.0064 | 0.038 | 0.5415 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.0804 | 0.0791 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0688 | 0.5628 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.234 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.0804 | 0.0791 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0044 | 0.0221 | 0.5651 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1212 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Mycobacterium tuberculosis | Possible ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit beta | 0.037 | 0.2804 | 0.2794 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0169 | 0.1212 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.0804 | 0.0791 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | ATP-dependent DNA helicase rep, putative | 0.0038 | 0.0176 | 0.2553 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0044 | 0.0221 | 0.147 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.2012 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Echinococcus multilocularis | GPCR, family 2 | 0.0053 | 0.0297 | 0.0389 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.0038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0688 | 0.4804 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.038 | 0.038 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD2 | 0.0038 | 0.0176 | 0.0161 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0223 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.093 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0169 | 0.1212 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0281 | 0.2211 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0688 | 1 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0053 | 0.0297 | 0.2012 |
Treponema pallidum | rep helicase, single-stranded DNA-dependent ATPase (rep) | 0.0038 | 0.0176 | 0.999 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.7263 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0904 | 0.7419 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.0908 | 0.0895 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0904 | 0.7424 |
Echinococcus granulosus | geminin | 0.0195 | 0.1417 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0176 | 0.0176 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0015 | 0.0015 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0169 | 0.1212 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium tuberculosis | Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e | 0.0408 | 0.3107 | 0.3097 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0053 | 0.0297 | 0.2357 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.0389 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0044 | 0.0221 | 0.3208 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0281 | 0.0267 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0904 | 0.7419 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0281 | 0.2227 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.0368 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.0908 | 0.0895 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0281 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0688 | 0.5618 |
Chlamydia trachomatis | DNA helicase | 0.0038 | 0.0176 | 0.0161 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.0908 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0015 | 0.0015 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Mycobacterium tuberculosis | Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) | 0.1277 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease V (alpha chain), RecD | 0.0607 | 0.4687 | 0.4687 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0115 | 0.0788 | 0.6462 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.025 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.4804 |
Echinococcus multilocularis | geminin | 0.0195 | 0.1417 | 0.1935 |
Wolbachia endosymbiont of Brugia malayi | superfamily I DNA/RNA helicase | 0.0038 | 0.0176 | 0.999 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.0284 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0044 | 0.0221 | 0.3208 |
Mycobacterium ulcerans | ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0176 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0017 | 0.0096 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0281 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0788 | 0.6455 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0281 | 0.3958 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0688 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.0389 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.0804 | 0.0791 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease V (gamma chain), RecC | 0.1277 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.147 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent exoDNAse (exonuclease V) beta subunit, RecB | 0.0038 | 0.0176 | 0.999 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0002 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.0804 | 0.0791 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0017 | 0.0003 |
Treponema pallidum | DNA helicase II (uvrD) | 0.0038 | 0.0176 | 0.999 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0281 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.0038 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.0804 | 0.0791 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Schistosoma mansoni | kinase | 0.0052 | 0.0288 | 0.1946 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0297 | 0.234 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Plasmodium vivax | ATP-dependent DNA helicase UvrD, putative | 0.0038 | 0.0176 | 0.6042 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0015 |
Mycobacterium ulcerans | exodeoxyribonuclease V (beta chain), RecB | 0.037 | 0.2804 | 0.2804 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0281 | 0.7308 |
Plasmodium falciparum | ATP-dependent DNA helicase UvrD | 0.0038 | 0.0176 | 0.6042 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0281 | 0.2227 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.0908 | 0.0895 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0788 | 0.5516 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Wolbachia endosymbiont of Brugia malayi | RecB exonuclease | 0.0038 | 0.0176 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.1901 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.2357 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0102 | 0.0682 | 0.6917 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.2012 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0281 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Toxoplasma gondii | hypothetical protein | 0.0064 | 0.038 | 1 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0.0176 | 0.0162 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0017 | 0.0096 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0176 | 0.115 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Toxoplasma gondii | UvrD/REP helicase domain-containing protein | 0.0038 | 0.0176 | 0.4416 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.0804 | 0.8581 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | = 1.5 molar ratio | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as ratio of molar concentration of compound to LH-RH for inhibition of LH-RH-stimulated LH release after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Inhibition (binding) | = 100 % | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as inhibition of LH-RH-stimulated LH release at compound to LH-RH molar ratio of 20 after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.