Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0044 | 0.0221 | 0.3208 |
Schistosoma mansoni | kinase | 0.0052 | 0.0288 | 0.1946 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.025 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0281 | 0.2227 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent exoDNAse (exonuclease V) beta subunit, RecB | 0.0038 | 0.0176 | 0.999 |
Mycobacterium leprae | conserved hypothetical protein | 0.0102 | 0.0682 | 0.6917 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0017 | 0.0004 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Trichomonas vaginalis | ATP-dependent DNA helicase rep, putative | 0.0038 | 0.0176 | 0.2553 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0002 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Echinococcus granulosus | GPCR family 2 | 0.0053 | 0.0297 | 0.2012 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0053 | 0.0297 | 0.2357 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0281 | 0.7308 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0.0176 | 0.0162 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.2012 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0281 | 0.2211 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0281 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.0038 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.1901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0281 | 0.2211 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0161 |
Wolbachia endosymbiont of Brugia malayi | superfamily I DNA/RNA helicase | 0.0038 | 0.0176 | 0.999 |
Treponema pallidum | DNA helicase II (uvrD) | 0.0038 | 0.0176 | 0.999 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0688 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Mycobacterium ulcerans | exodeoxyribonuclease V (gamma chain), RecC | 0.1277 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0281 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1212 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.0804 | 0.0791 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.7263 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0017 | 0.0003 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0297 | 0.234 |
Wolbachia endosymbiont of Brugia malayi | RecB exonuclease | 0.0038 | 0.0176 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.0908 | 0.0895 |
Echinococcus granulosus | geminin | 0.0195 | 0.1417 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD2 | 0.0038 | 0.0176 | 0.0161 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0788 | 0.5516 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0281 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.2012 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.4804 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0281 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.0804 | 0.0791 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0281 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0176 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0176 | 0.115 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium tuberculosis | Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) | 0.0607 | 0.4687 | 0.4679 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Mycobacterium ulcerans | exodeoxyribonuclease V (alpha chain), RecD | 0.0607 | 0.4687 | 0.4687 |
Echinococcus multilocularis | geminin | 0.0195 | 0.1417 | 0.1935 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0169 | 0.1212 | 1 |
Mycobacterium tuberculosis | Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) | 0.1277 | 1 | 1 |
Chlamydia trachomatis | DNA helicase | 0.0038 | 0.0176 | 0.0161 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0017 | 0.0096 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.0908 | 1 |
Mycobacterium tuberculosis | Possible ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Plasmodium vivax | ATP-dependent DNA helicase UvrD, putative | 0.0038 | 0.0176 | 0.6042 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.0804 | 0.0791 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0044 | 0.0221 | 0.5651 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.0804 | 0.8581 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0281 | 0.3958 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0044 | 0.0221 | 0.147 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.0908 | 0.0895 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0788 | 0.6455 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0017 | 0.0096 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.0389 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.0368 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.2357 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0904 | 0.7419 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0115 | 0.0788 | 0.6462 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0904 | 0.7424 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Toxoplasma gondii | hypothetical protein | 0.0064 | 0.038 | 1 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0281 | 0.2227 |
Treponema pallidum | ATP-dependent nuclease, subunit A | 0.0038 | 0.0176 | 0.999 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.038 | 0.038 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.234 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0169 | 0.1212 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0015 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0176 | 0.0176 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0688 | 0.4804 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Mycobacterium tuberculosis | Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e | 0.0408 | 0.3107 | 0.3097 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0904 | 0.7419 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.0804 | 0.0791 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.0804 | 0.0791 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.0804 | 0.0791 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Toxoplasma gondii | UvrD/REP helicase domain-containing protein | 0.0038 | 0.0176 | 0.4416 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0044 | 0.0221 | 0.3208 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0015 | 0.0015 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0169 | 0.1212 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.147 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.093 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0015 | 0.0213 |
Echinococcus multilocularis | GPCR, family 2 | 0.0053 | 0.0297 | 0.0389 |
Giardia lamblia | RNA helicase, putative | 0.0064 | 0.038 | 0.5415 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0015 | 0.0213 |
Treponema pallidum | rep helicase, single-stranded DNA-dependent ATPase (rep) | 0.0038 | 0.0176 | 0.999 |
Plasmodium falciparum | ATP-dependent DNA helicase UvrD | 0.0038 | 0.0176 | 0.6042 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0688 | 0.5628 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0688 | 0.5618 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.0389 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0688 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease V (beta chain), RecB | 0.037 | 0.2804 | 0.2804 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit beta | 0.037 | 0.2804 | 0.2794 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.0908 | 0.0895 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0223 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | = 1.5 molar ratio | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as ratio of molar concentration of compound to LH-RH for inhibition of LH-RH-stimulated LH release after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Inhibition (binding) | = 100 % | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as inhibition of LH-RH-stimulated LH release at compound to LH-RH molar ratio of 20 after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.