Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.0038 |
Treponema pallidum | DNA helicase II (uvrD) | 0.0038 | 0.0176 | 0.999 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0017 | 0.0003 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.0804 | 0.0791 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0281 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.0804 | 0.0791 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Schistosoma mansoni | kinase | 0.0052 | 0.0288 | 0.1946 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease V (gamma chain), RecC | 0.1277 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.0804 | 0.0791 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0788 | 0.6455 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0281 | 1 |
Mycobacterium ulcerans | ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0176 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0017 | 0.0096 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0044 | 0.0221 | 0.3208 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.0284 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0281 | 0.3958 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent exoDNAse (exonuclease V) beta subunit, RecB | 0.0038 | 0.0176 | 0.999 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.147 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.2012 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0281 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0102 | 0.0682 | 0.6917 |
Toxoplasma gondii | hypothetical protein | 0.0064 | 0.038 | 1 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Wolbachia endosymbiont of Brugia malayi | RecB exonuclease | 0.0038 | 0.0176 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.2357 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.1901 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Toxoplasma gondii | UvrD/REP helicase domain-containing protein | 0.0038 | 0.0176 | 0.4416 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.0804 | 0.8581 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0.0176 | 0.0162 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0176 | 0.115 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0017 | 0.0096 |
Plasmodium vivax | ATP-dependent DNA helicase UvrD, putative | 0.0038 | 0.0176 | 0.6042 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0297 | 0.234 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Mycobacterium ulcerans | exodeoxyribonuclease V (beta chain), RecB | 0.037 | 0.2804 | 0.2804 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0788 | 0.5516 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.0908 | 0.0895 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0017 | 0.0004 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Plasmodium falciparum | ATP-dependent DNA helicase UvrD | 0.0038 | 0.0176 | 0.6042 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0281 | 0.7308 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0281 | 0.2227 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Trichomonas vaginalis | ATP-dependent DNA helicase rep, putative | 0.0038 | 0.0176 | 0.2553 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.0804 | 0.0791 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0044 | 0.0221 | 0.147 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit beta | 0.037 | 0.2804 | 0.2794 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Mycobacterium tuberculosis | Possible ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0169 | 0.1212 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.038 | 0.038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0688 | 0.4804 |
Echinococcus multilocularis | GPCR, family 2 | 0.0053 | 0.0297 | 0.0389 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.2012 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.0038 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.0804 | 0.0791 |
Giardia lamblia | RNA helicase, putative | 0.0064 | 0.038 | 0.5415 |
Mycobacterium tuberculosis | Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) | 0.0607 | 0.4687 | 0.4679 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Treponema pallidum | ATP-dependent nuclease, subunit A | 0.0038 | 0.0176 | 0.999 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0161 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0281 | 0.2211 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0044 | 0.0221 | 0.5651 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1212 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0688 | 0.5628 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.0804 | 0.0791 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.234 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.0908 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium ulcerans | exodeoxyribonuclease V (alpha chain), RecD | 0.0607 | 0.4687 | 0.4687 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium tuberculosis | Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) | 0.1277 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0015 | 0.0015 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0281 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0688 | 0.5618 |
Chlamydia trachomatis | DNA helicase | 0.0038 | 0.0176 | 0.0161 |
Wolbachia endosymbiont of Brugia malayi | superfamily I DNA/RNA helicase | 0.0038 | 0.0176 | 0.999 |
Echinococcus multilocularis | geminin | 0.0195 | 0.1417 | 0.1935 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0115 | 0.0788 | 0.6462 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.4804 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.025 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0053 | 0.0297 | 0.2012 |
Treponema pallidum | rep helicase, single-stranded DNA-dependent ATPase (rep) | 0.0038 | 0.0176 | 0.999 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0176 | 0.0176 |
Echinococcus granulosus | geminin | 0.0195 | 0.1417 | 1 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0904 | 0.7424 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.0908 | 0.0895 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0904 | 0.7419 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.7263 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0223 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD2 | 0.0038 | 0.0176 | 0.0161 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0281 | 0.2211 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0169 | 0.1212 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.093 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0281 | 0.0267 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0044 | 0.0221 | 0.3208 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.0389 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.0368 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.0908 | 0.0895 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0281 | 0.2227 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0904 | 0.7419 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0015 | 0.0015 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0169 | 0.1212 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0015 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0053 | 0.0297 | 0.2357 |
Mycobacterium tuberculosis | Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e | 0.0408 | 0.3107 | 0.3097 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | = 3 molar ratio | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as ratio of molar concentration of compound to LH-RH for inhibition of LH-RH-stimulated LH release after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Inhibition (binding) | = 100 % | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as inhibition of LH-RH-stimulated LH release at compound to LH-RH molar ratio of 20 after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.