Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0281 | 0.0267 |
Wolbachia endosymbiont of Brugia malayi | RecB exonuclease | 0.0038 | 0.0176 | 1 |
Echinococcus multilocularis | geminin | 0.0195 | 0.1417 | 0.1935 |
Plasmodium vivax | ATP-dependent DNA helicase UvrD, putative | 0.0038 | 0.0176 | 0.6042 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.0284 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0688 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent exoDNAse (exonuclease V) beta subunit, RecB | 0.0038 | 0.0176 | 0.999 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Echinococcus granulosus | geminin | 0.0195 | 0.1417 | 1 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0044 | 0.0221 | 0.147 |
Treponema pallidum | DNA helicase II (uvrD) | 0.0038 | 0.0176 | 0.999 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.0038 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.0804 | 0.0791 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.0368 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0044 | 0.0221 | 0.3208 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0017 | 0.0003 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.0389 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.0804 | 0.0791 |
Wolbachia endosymbiont of Brugia malayi | superfamily I DNA/RNA helicase | 0.0038 | 0.0176 | 0.999 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0002 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.0804 | 0.0791 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0281 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0281 | 0.2227 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.1417 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0277 | 0.402 |
Giardia lamblia | RNA helicase, putative | 0.0064 | 0.038 | 0.5415 |
Mycobacterium leprae | conserved hypothetical protein | 0.0102 | 0.0682 | 0.6917 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0053 | 0.0297 | 0.2357 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0.0176 | 0.0162 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.025 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0169 | 0.1212 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.0804 | 0.8581 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0044 | 0.0221 | 0.3208 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0688 | 0.5628 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0015 | 0.0213 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0015 | 0.0213 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0176 | 0.115 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.2357 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.2012 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1704 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0297 | 0.234 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0281 | 0.2227 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0017 | 0.025 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0281 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0044 | 0.0221 | 0.7732 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1212 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0044 | 0.0221 | 0.1722 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.4804 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0015 | 0.0015 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0004 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0044 | 0.0221 | 0.147 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0788 | 0.5516 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.007 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0281 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease V (alpha chain), RecD | 0.0607 | 0.4687 | 0.4687 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Treponema pallidum | rep helicase, single-stranded DNA-dependent ATPase (rep) | 0.0038 | 0.0176 | 0.999 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Trichomonas vaginalis | ATP-dependent DNA helicase rep, putative | 0.0038 | 0.0176 | 0.2553 |
Mycobacterium tuberculosis | Possible ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0465 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.038 | 0.038 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus multilocularis | GPCR, family 2 | 0.0053 | 0.0297 | 0.0389 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0017 | 0.0096 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0904 | 0.7424 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0297 | 0.2012 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0688 | 0.093 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0904 | 0.7419 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Mycobacterium tuberculosis | Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) | 0.1277 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.0908 | 0.0895 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.0908 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0017 | 0.0004 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0297 | 0.2012 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD2 | 0.0038 | 0.0176 | 0.0161 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0281 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0161 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.0804 | 0.0791 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0688 | 0.4804 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0297 | 0.0389 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.3208 |
Plasmodium falciparum | ATP-dependent DNA helicase UvrD | 0.0038 | 0.0176 | 0.6042 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0018 |
Schistosoma mansoni | kinase | 0.0052 | 0.0288 | 0.1946 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0053 | 0.0297 | 0.234 |
Treponema pallidum | ATP-dependent nuclease, subunit A | 0.0038 | 0.0176 | 0.999 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0176 | 0.0176 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0115 | 0.0788 | 0.6462 |
Toxoplasma gondii | hypothetical protein | 0.0064 | 0.038 | 1 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0607 | 0.4687 | 0.4679 |
Mycobacterium tuberculosis | Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific e | 0.0408 | 0.3107 | 0.3097 |
Mycobacterium ulcerans | exodeoxyribonuclease V (gamma chain), RecC | 0.1277 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0017 | 0.0096 |
Mycobacterium ulcerans | ATP-dependent DNA helicase II UvrD1 | 0.0038 | 0.0176 | 0.0176 |
Mycobacterium ulcerans | exodeoxyribonuclease V (beta chain), RecB | 0.037 | 0.2804 | 0.2804 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0044 | 0.0221 | 0.306 |
Trypanosoma cruzi | ATP-dependent DNA helicase, putative | 0.0038 | 0.0176 | 0.2391 |
Chlamydia trachomatis | DNA helicase | 0.0038 | 0.0176 | 0.0161 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0017 | 0.0021 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0169 | 0.1212 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0281 | 0.3958 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0688 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Mycobacterium tuberculosis | Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) | 0.0607 | 0.4687 | 0.4679 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0044 | 0.0221 | 0.5651 |
Echinococcus granulosus | GPCR family 2 | 0.0053 | 0.0297 | 0.2012 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.0804 | 0.0791 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0281 | 0.4086 |
Mycobacterium ulcerans | ATP-dependent DNA helicase | 0.0076 | 0.0478 | 0.0478 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0017 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0688 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.7263 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0904 | 0.7419 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0788 | 0.6455 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0281 | 0.2211 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0015 | 0.0213 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0281 | 0.2211 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.0908 | 0.0895 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0688 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0281 | 0.1901 |
Toxoplasma gondii | UvrD/REP helicase domain-containing protein | 0.0038 | 0.0176 | 0.4416 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit beta | 0.037 | 0.2804 | 0.2794 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.0804 | 0.0791 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0015 | 0.0213 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0169 | 0.1212 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.0908 | 0.0895 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0688 | 0.5618 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0015 | 0.0015 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0015 | 0.0213 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0281 | 0.7308 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0038 | 0.0176 | 0.0223 |
Treponema pallidum | hypothetical protein | 0.0038 | 0.0176 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 81 % | In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as inhibition of LH-RH-stimulated LH release at compound to LH-RH molar ratio of 1000 after 4 hrs by radioimmunoassay | ChEMBL. | 385877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.