Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0082 | 0.0978 | 0.1211 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0507 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0041 | 0.009 | 0.0083 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0408 | 0.789 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | carboxylesterase | 0.0058 | 0.045 | 0.057 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0679 | 0.0832 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0978 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0679 | 0.0832 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0408 | 0.789 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0341 | 0.6472 | 0.8196 |
Schistosoma mansoni | gliotactin | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | protein kinase shaggy | 0.0082 | 0.0978 | 0.1211 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0058 | 0.045 | 0.054 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.0978 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0341 | 0.6472 | 0.8202 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.1932 | 0.2424 |
Plasmodium vivax | chorismate synthase | 0.0204 | 0.3559 | 1 |
Mycobacterium ulcerans | chorismate synthase | 0.0204 | 0.3559 | 0.3256 |
Echinococcus granulosus | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Giardia lamblia | Kinase, CMGC GSK | 0.0082 | 0.0978 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0058 | 0.045 | 0.4459 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0082 | 0.0978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0082 | 0.0978 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0041 | 0.009 | 0.0114 |
Echinococcus multilocularis | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Echinococcus multilocularis | insulin receptor | 0.0041 | 0.009 | 0.0083 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0068 | 0.0679 | 0.0832 |
Echinococcus multilocularis | 0.0039 | 0.0063 | 0.0048 | |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.009 | 0.0083 |
Chlamydia trachomatis | chorismate synthase | 0.0204 | 0.3559 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0341 | 0.6472 | 0.8196 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0082 | 0.0978 | 0.2695 |
Echinococcus multilocularis | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0978 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0408 | 0.789 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0127 | 0.1932 | 0.2424 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Plasmodium falciparum | chorismate synthase | 0.0204 | 0.3559 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Echinococcus multilocularis | neuroligin | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0127 | 0.1932 | 0.2424 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0058 | 0.045 | 0.054 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Onchocerca volvulus | 0.0082 | 0.0978 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0408 | 0.789 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0068 | 0.0679 | 0.0832 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0507 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6472 | 0.8202 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0082 | 0.0978 | 0.1211 |
Loa Loa (eye worm) | carboxylesterase | 0.0341 | 0.6472 | 0.8202 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0408 | 0.789 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0082 | 0.0978 | 0.1211 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0082 | 0.0978 | 0.1239 |
Brugia malayi | intracellular kinase | 0.0082 | 0.0978 | 0.1211 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0127 | 0.1932 | 0.2448 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0041 | 0.009 | 0.0083 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0082 | 0.0978 | 0.1239 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | carboxylesterase 5A | 0.0341 | 0.6472 | 0.8196 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0082 | 0.0978 | 0.2695 |
Echinococcus multilocularis | protein kinase shaggy | 0.0082 | 0.0978 | 0.1211 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.009 | 0.0083 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0068 | 0.0679 | 0.0832 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.009 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6472 | 0.8202 |
Mycobacterium leprae | Isocitrate lyase | 0.0238 | 0.4276 | 0.3373 |
Trypanosoma brucei | protein kinase, putative | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | neuroligin | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | insulin receptor | 0.0041 | 0.009 | 0.0083 |
Toxoplasma gondii | chorismate synthase, putative | 0.0204 | 0.3559 | 1 |
Brugia malayi | hypothetical protein | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | carboxylesterase | 0.0058 | 0.045 | 0.057 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0978 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0082 | 0.0978 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0058 | 0.045 | 0.4459 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0507 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0127 | 0.1932 | 0.2424 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Echinococcus granulosus | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0101 | 0.1362 | 0.0956 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0058 | 0.045 | 0.054 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0082 | 0.0978 | 0.2695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.