Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | jun protein | 0.0094 | 0.0358 | 0.0692 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0094 | 0.0358 | 0.0692 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0175 | 0.227 | 0.4385 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Brugia malayi | bZIP transcription factor family protein | 0.0094 | 0.0358 | 0.0358 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0297 | 0.0297 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0175 | 0.227 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0298 | 0.5176 | 1 |
Echinococcus granulosus | jun protein | 0.0094 | 0.0358 | 0.0692 |
Schistosoma mansoni | choline o-acyltransferase | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 1 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0175 | 0.227 | 0.227 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0175 | 0.227 | 0.4385 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5176 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0298 | 0.5176 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0175 | 0.227 | 0.227 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0094 | 0.0358 | 0.0692 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0298 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5176 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0175 | 0.227 | 0.4385 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0175 | 0.227 | 0.4385 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0326 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 0.3101 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 19.9222 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.