Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0298 | 0.5172 | 1 |
Schistosoma mansoni | jun-related protein | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0175 | 0.2263 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0175 | 0.2263 | 0.3863 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0175 | 0.2263 | 0.1914 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0175 | 0.2263 | 0.3863 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0298 | 0.5172 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5172 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0175 | 0.2263 | 0.1967 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0298 | 0.5172 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5172 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0981 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.0986 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 15.0416 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.