Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 1 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.0348 | 0.706 | 0.5 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0269 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.5176 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0269 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.5176 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0348 | 0.706 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0269 | 0.5176 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0858 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 1.4251 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 29.6956 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.