Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 1B (muscle) | 738 aa | 617 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0069 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0376 | 0.4289 | 0.8242 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0376 | 0.4289 | 1 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0376 | 0.4289 | 1 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0441 | 0.5204 | 0.5204 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0069 | 0 | 0.5 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0441 | 0.5204 | 0.5204 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0441 | 0.5204 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0441 | 0.5204 | 1 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0376 | 0.4289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0785 | 1 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0376 | 0.4289 | 0.8242 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0069 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0441 | 0.5204 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0441 | 0.5204 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0552 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.0561 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 1.0806 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.