Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1B (muscle) | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 1B (muscle) | 738 aa | 617 aa | 28.0 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0195 | 0.1343 | 0.3132 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0406 | 0.4289 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0406 | 0.4289 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0406 | 0.4289 | 1 |
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0195 | 0.1343 | 0.3132 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0195 | 0.1343 | 0.3132 |
Schistosoma mansoni | choline o-acyltransferase | 0.0099 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0195 | 0.1343 | 0.1343 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0195 | 0.1343 | 0.1343 |
Schistosoma mansoni | choline o-acyltransferase | 0.0099 | 0 | 0.5 |
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0406 | 0.4289 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0195 | 0.1343 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0406 | 0.4289 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0195 | 0.1343 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0613 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.1023 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 1.7448 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | = 4.4512 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 37.3611 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.